口腔微生物群在人体微生物组和口腔健康中起着至关重要的作用。微生物与其宿主之间的失衡可导致口腔和全身性疾病,如糖尿病或心血管疾病。这篇综述的目的是调查口腔微生物群生态失调对口腔健康的文献证据,并讨论当前知识和新兴的口腔微生物协同作用和生态失调机制;两者都增强了我们对致病机制的理解,并有助于设计创新的治疗方法作为ORALBIOTICA用于口腔疾病,例如脱矿质。PubMed,WebofScience,谷歌学者,Scopus,科克伦图书馆,嵌入,牙科和口腔科学来源通过EBSCO,APAPsycINFO,APAPsyArticles,从2017年1月至2022年4月22日,搜索了DRUGS@FDA与我们的主题相匹配的出版物,并使用以下布尔关键字对英语进行了限制:(\"microbio*\"和\"脱矿质*\")和(\"口腔微生物群\"和\"脱矿质\")。纳入22项研究进行定性分析。从这篇综述中的研究可以看出,微生物群的平衡是不稳定的,受口腔卫生的影响,口腔中正畸装置的存在和不良的饮食习惯,可以改变其组成和行为的积极和消极的方式,增加去矿化的发展,龋齿过程,和牙周病.在生态失调的条件下,受酸性环境的青睐,特定细菌菌株的繁殖增加,有利于龋齿,如双歧杆菌,长双歧杆菌,还有S.mutans,比唾液链球菌和粘虫,并增加了Firmicutes菌株,从而使Bacteroides处于不利地位。通过使用益生菌和益生元管理和治疗口腔疾病,可以恢复微生物平衡,漱口水或饮食修饰可以影响微生物群平衡并预防或减缓疾病进展。
The oral microbiota plays a vital role in the human microbiome and oral health. Imbalances between microbes and their hosts can lead to oral and systemic disorders such as diabetes or cardiovascular disease. The purpose of this
review is to investigate the literature evidence of oral microbiota dysbiosis on oral health and discuss current knowledge and emerging mechanisms governing oral polymicrobial synergy and dysbiosis; both have enhanced our understanding of pathogenic mechanisms and aided the design of innovative therapeutic approaches as ORALBIOTICA for oral diseases such as demineralization. PubMed, Web of Science, Google Scholar, Scopus, Cochrane Library, EMBEDDED, Dentistry & Oral Sciences Source via EBSCO, APA PsycINFO, APA PsyArticles, and DRUGS@FDA were searched for publications that matched our topic from January 2017 to 22 April 2022, with an English language constraint using the following Boolean keywords: (\"microbio*\" and \"demineralization*\") AND (\"oral microbiota\" and \"demineralization\"). Twenty-two studies were included for qualitative analysis. As seen by the studies included in this
review, the balance of the microbiota is unstable and influenced by oral hygiene, the presence of orthodontic devices in the oral cavity and poor eating habits that can modify its composition and behavior in both positive and negative ways, increasing the development of demineralization, caries processes, and periodontal disease. Under conditions of dysbiosis, favored by an acidic environment, the reproduction of specific bacterial strains increases, favoring cariogenic ones such as Bifidobacterium dentium, Bifidobacterium longum, and S. mutans, than S. salivarius and A. viscosus, and increasing of Firmicutes strains to the disadvantage of Bacteroidetes. Microbial balance can be restored by using probiotics and prebiotics to manage and treat oral diseases, as evidenced by mouthwashes or dietary modifications that can influence microbiota balance and prevent or slow disease progression.