■心血管代谢危险因素在心血管和代谢疾病的发展中起着至关重要的作用。基础代谢率(BMR)是影响能量消耗的基本生理参数,并可能导致这些危险因素的变化。然而,BMR与心脏代谢危险因素之间的确切关系尚不清楚.
■我们采用孟德尔随机化(MR)分析来探索BMR(N:534,045)与各种心脏代谢危险因素之间的关联,包括体重指数(BMI,N:681,275),空腹血糖(N:200,622),高密度脂蛋白(HDL)胆固醇(N=403,943),低密度脂蛋白(LDL)胆固醇(N=431,167),总胆固醇(N:344,278),和甘油三酯(N:441,016),C反应蛋白(N:436,939),腰围(N:232,101),收缩压(N:810,865),舒张压(N:810,865),糖化血红蛋白(N:389,889),和N-末端激素原脑钠肽(N:21,758)。我们利用与BMR密切相关的遗传变异作为工具变量来研究潜在的因果关系,主要分析使用逆方差加权(IVW)方法。
■我们的MR分析揭示了BMR与特定心脏代谢危险因素之间存在因果关系的令人信服的证据。具体来说,遗传决定的较高BMR与BMI增加相关(β=0.7538,95%置信区间[CI]:0.6418至0.8659,p<0.001),HDL胆固醇水平较低(β=-0.3293,95%CI:0.4474至-0.2111,p<0.001),甘油三酯水平较高(β=0.1472,95%CI:0.0370至0.2574,p=0.0088),腰围(β=0.4416,95%CI:0.2949至0.5883,p<0.001),和糖化血红蛋白(β=0.1037,95%CI:0.0080至0.1995,p=0.0377)。然而,我们没有观察到BMR和空腹血糖之间的任何显著关联,LDL胆固醇,总胆固醇,C反应蛋白,收缩压,舒张压,或N末端激素原脑钠肽(所有p值>0.05)。
■这项MR研究为BMR与心脏代谢危险因素之间的关系提供了有价值的见解。了解BMR与这些因素之间的因果关系可能对制定有针对性的干预措施和疗法具有重要意义。
UNASSIGNED: Cardio-metabolic risk factors play a crucial role in the development of cardiovascular and metabolic diseases. Basal metabolic rate (BMR) is a fundamental physiological parameter that affects energy expenditure and might contribute to variations in these risk factors. However, the exact relationship between BMR and cardio-metabolic risk factors has remained unclear.
UNASSIGNED: We employed Mendelian Randomization (MR) analysis to explore the association between BMR (N: 534,045) and various cardio-metabolic risk factors, including body mass index (BMI, N: 681,275), fasting glucose (N: 200,622), high-density lipoprotein (HDL) cholesterol (N = 403,943), low-density lipoprotein (LDL) cholesterol (N = 431,167), total cholesterol (N: 344,278), and triglycerides (N: 441,016), C-reactive protein (N: 436,939), waist circumference (N: 232,101), systolic blood pressure (N: 810,865), diastolic blood pressure (N: 810,865), glycated haemoglobin (N: 389,889), and N-terminal prohormone brain natriuretic peptide (N: 21,758). We leveraged genetic variants strongly associated with BMR as instrumental variables to investigate potential causal relationships, with the primary analysis using the Inverse Variance Weighted (IVW) method.
UNASSIGNED: Our MR analysis revealed compelling
evidence of a causal link between BMR and specific cardio-metabolic risk factors. Specifically, genetically determined higher BMR was associated with an increased BMI (β = 0.7538, 95% confidence interval [CI]: 0.6418 to 0.8659, p < 0.001), lower levels of HDL cholesterol (β = -0.3293, 95% CI: 0.4474 to -0.2111, p < 0.001), higher levels of triglycerides (β = 0.1472, 95% CI: 0.0370 to 0.2574, p = 0.0088), waist circumference (β = 0.4416, 95% CI: 0.2949 to 0.5883, p < 0.001), and glycated haemoglobin (β = 0.1037, 95% CI: 0.0080 to 0.1995, p = 0.0377). However, we did not observe any significant association between BMR and fasting glucose, LDL cholesterol, total cholesterol, C-reactive protein, systolic blood pressure, diastolic blood pressure, or N-terminal prohormone brain natriuretic peptide (all p-values>0.05).
UNASSIGNED: This MR
study provides valuable insights into the relationship between BMR and cardio-metabolic risk factors. Understanding the causal links between BMR and these factors could have important implications for the development of targeted interventions and therapies.