太仓和武强队列研究(TAWS)的建立是为了检查生命早期营养与儿童健康之间的关系,探索孕产妇健康的潜在作用,中国两个不同地区儿童健康中的代谢产物和微生物群。
在妊娠早期(n=4035,57.3%)或分娩阶段(n=3006,42.7%),从太仓和武强的卫生中心或医院共招募了7041对母子。母子在怀孕期间进行了三次随访,一次在交付期间,和7-10次在3年后交货。问卷调查用于收集饮食数据,补充摄入量,身体活动,抑郁量表,疾病发生,儿童的喂养实践和发育商。每次访问时评估母亲及其子女的人体测量。从医疗记录中提取妊娠结局。收集并储存生物标本,包括静脉血,脐带血,尿液,凳子,母乳,脐带和胎盘。
来自TAWS队列的数据显示在TAWS的两个站点处参与者的不同基线特征。代谢异常发生在母亲被诊断为妊娠糖尿病的新生儿中。孕妇在妊娠早期血清叶酸高于14.5ng/mL与分娩小于胎龄新生儿的风险降低相关。
母亲营养与后代健康之间的关联将在各种随访中进行检查。将对生物标志物进行分析,以评估早期营养与儿童发育之间的关联。免疫力和健康。最佳婴儿喂养实践的战略建议,肥胖预防和常规医疗保健项目将根据研究结果制定和提出。这项前瞻性队列研究中的儿童将每年随访一次,直到12岁,以进一步检查早期营养与儿童长期发育和健康之间的关系。
The Taicang and Wuqiang cohort
study (TAWS) was established to examine the association between early-life nutrition and children\'s health, and to explore the potential roles of maternal health, metabolites and microbiota in children\'s health in two different regions of China.
A total of 7041 mother-child pairs were recruited during early pregnancy (n=4035, 57.3%) or delivery phase (n=3006, 42.7%) from health centres or hospitals in Taicang and Wuqiang. Mother-child pairs were followed up three times during pregnancy, once during delivery, and 7-10 times in the 3 years after delivery. Questionnaires were used to collect data on diet, supplementary intake, physical activity, depression scale, disease occurrence, feeding practice and development quotient of children. Anthropometric measurements of mothers and their children were assessed at each visit. Pregnancy outcomes were extracted from medical records. Biospecimens were collected and stored, including venous blood, cord blood, urine, stool, breast milk, cord and placenta.
Data from the TAWS cohort showed different baseline characteristics of participants at the two sites of TAWS. Abnormal metabolism occurred among newborns whose mothers were diagnosed with gestational diabetes mellitus. Maternal serum folic acid above 14.5 ng/mL at early pregnancy was associated with a reduced risk of delivering small-for-gestational-age newborns.
The association between maternal nutrition and the health of offspring will be examined at various follow-up visits. Biomarkers will be analysed to assess the associations between early-life nutrition and child development, immunity and health. Strategic recommendations for optimal infant feeding practices, obesity prevention and routine healthcare items will be developed and proposed based on the findings from the
study. Children in this prospective cohort
study will be followed up once a year until age 12 years to further examine the relationships between early-life nutrition and children\'s long-term development and health.