PDF(Pubmed)
Abstract：
BACKGROUND: Stroke is a life-threatening condition that causes a major medical burden globally. The currently used methods for the prevention or prediction of stroke have certain limitations. Exposure to tobacco in early life, including smoking during adolescence and maternal smoking during pregnancy, can affect adolescent development and lead to several negative outcomes. However, the association between early-life tobacco exposure and stroke is not known.
METHODS: In this prospective cohort study, for the analyses involving exposure to maternal smoking during pregnancy and age of smoking initiation, we included 304,984 and 342,893 participants, respectively., respectively from the UK Biobank. Cox proportional hazard regression model and subgroup analyses were performed to investigate the association between early-life tobacco exposure and stroke. Mediation analyses were performed to identify the mediating role of biological aging in the association between early tobacco exposure and stroke.
RESULTS: Compared with participants whose mothers did not smoke during pregnancy, participants whose mothers smoked during pregnancy showed an 11% increased risk of stroke (HR: 1.11, 95% CI: 1.05-1.18, P < 0.001). Compared with participants who never smoked, participants who smoked during adulthood, adolescence and childhood showed a 22%, 24%, and 38% increased risk of stroke during their adulthood, respectively. Mediation analysis indicated that early-life tobacco exposure can cause stroke by increasing biological aging.
CONCLUSIONS: This study reveals that exposure to tobacco during early life is associated with an increased risk of experiencing a stroke, and increased biological aging can be the underlying mechanism.
METHODS: In this prospective cohort study, for the analyses involving exposure to maternal smoking during pregnancy and age of smoking initiation, we included 304,984 and 342,893 participants, respectively., respectively from the UK Biobank. Cox proportional hazard regression model and subgroup analyses were performed to investigate the association between early-life tobacco exposure and stroke. Mediation analyses were performed to identify the mediating role of biological aging in the association between early tobacco exposure and stroke.
RESULTS: Compared with participants whose mothers did not smoke during pregnancy, participants whose mothers smoked during pregnancy showed an 11% increased risk of stroke (HR: 1.11, 95% CI: 1.05-1.18, P < 0.001). Compared with participants who never smoked, participants who smoked during adulthood, adolescence and childhood showed a 22%, 24%, and 38% increased risk of stroke during their adulthood, respectively. Mediation analysis indicated that early-life tobacco exposure can cause stroke by increasing biological aging.
CONCLUSIONS: This study reveals that exposure to tobacco during early life is associated with an increased risk of experiencing a stroke, and increased biological aging can be the underlying mechanism.
摘要：
背景：中风是一种危及生命的疾病，在全球范围内造成重大医疗负担。目前使用的预防或预测中风的方法具有一定的局限性。在生命早期接触烟草，包括青春期吸烟和孕期吸烟,会影响青少年的发展，并导致一些负面结果。然而,早期吸烟与卒中之间的关联尚不清楚.
方法：在这项前瞻性队列研究中，对于涉及怀孕期间母亲吸烟和开始吸烟年龄的分析，我们包括304,984和342,893名参与者，分别。,分别来自英国生物银行。进行Cox比例风险回归模型和亚组分析以研究早期烟草暴露与中风之间的关联。进行中介分析以确定生物老化在早期烟草暴露与中风之间的关联中的中介作用。
结果：与母亲在怀孕期间不吸烟的参与者相比，母亲在孕期吸烟的参与者卒中风险增加11%(HR:1.11,95%CI:1.05~1.18,P<0.001).与从不吸烟的参与者相比，在成年期间吸烟的参与者，青春期和童年表现为22%，24%,成年后中风的风险增加了38%，分别。中介分析表明，早期烟草暴露可通过增加生物衰老而导致中风。
结论：这项研究表明，在生命早期接触烟草会增加中风的风险，而增加的生物衰老可能是潜在的机制。
方法：在这项前瞻性队列研究中，对于涉及怀孕期间母亲吸烟和开始吸烟年龄的分析，我们包括304,984和342,893名参与者，分别。,分别来自英国生物银行。进行Cox比例风险回归模型和亚组分析以研究早期烟草暴露与中风之间的关联。进行中介分析以确定生物老化在早期烟草暴露与中风之间的关联中的中介作用。
结果：与母亲在怀孕期间不吸烟的参与者相比，母亲在孕期吸烟的参与者卒中风险增加11%(HR:1.11,95%CI:1.05~1.18,P<0.001).与从不吸烟的参与者相比，在成年期间吸烟的参与者，青春期和童年表现为22%，24%,成年后中风的风险增加了38%，分别。中介分析表明，早期烟草暴露可通过增加生物衰老而导致中风。
结论：这项研究表明，在生命早期接触烟草会增加中风的风险，而增加的生物衰老可能是潜在的机制。
