dry needling

干针刺
  • 文章类型: Journal Article
    这项研究的目的是比较压缩对比疗法(CT)和干针疗法(DN)对肌张力(MT)的急性影响,肌肉力量(Fmax),压力痛阈值(PPT),和前臂肌肉疲劳后的灌注(PU)(例如,radium屈肌)在格斗运动运动员中。采用单盲随机对照试验。参与者首先接受了肌肉疲劳诱导,其中包括在5秒周期内以其最大自愿收缩的60%维持等距手柄。随后是暴露于一种再生疗法。45名参与者被随机分为三组:CT/DN(n=15),CT/ShDN(n=15),和ShCT/DN(n=15)。假条件(Sh)涉及该技术的模拟版本。在四个时间点进行测量:(i)休息时;(ii)运动后立即导致疲劳状态;(iii)治疗后5分钟(PostTh5min);(iv)治疗后24小时(PostTh24h)。每个参与者都暴露在一个实验条件和一个对照条件下,从而在两个会议中进行评估。在Th5min后发现两组之间的MT存在显着差异(p=0.005),以及在PU后5分钟(p<0.001)和PU后24小时(p<0.001)。所有组在治疗后5分钟时与肌肉立即疲劳后相比显示出显著改善。作为结论,在5分钟的肌肉疲劳诱导后,CT/DN似乎对增强MT和PU明显更好。使用任一CT,DN,或两者结合,建议提高肌肉功能和性能的恢复,有利于恢复并可能加快性能增强。
    The aim of this study was to compare the acute effects of compression contrast therapy (CT) and dry needling therapy (DN) on muscle tension (MT), muscle strength (Fmax), pressure pain threshold (PPT), and perfusion (PU) following fatigue of forearm muscles (e.g., flexor carpi radialis) in combat sports athletes. A single-blind randomized controlled trial was employed. Participants first underwent muscle fatigue induction, which involved sustaining an isometric handgrip at 60% of their maximum voluntary contraction in 5-second cycles. This was followed by exposure to one of the regenerative therapies. Forty-five participants were randomly assigned to one of three groups: CT/DN (n = 15), CT/ShDN (n = 15), and ShCT/DN (n = 15). The sham condition (Sh) involved a simulated version of the technique. Measurements were taken at four time points: (i) at rest; (ii) immediately after exercise that led to a state of fatigue; (iii) 5 minutes after therapy (PostTh5min); and (iv) 24 hours after therapy (PostTh24h). Each participant was exposed to one experimental condition and one control condition, thereby undergoing evaluation in two sessions. Significant differences between groups were found in MT during the PostTh5min (p = 0.005), as well as in PU during the PostTh5min (p < 0.001) and PU during the PostTh24h (p < 0.001). All groups showed significant improvements at 5 minutes post-therapy compared to immediately post-muscle fatigue. As conclusions, CT/DN seems to be significantly better for enhancing MT and PU after 5 minutes of muscle fatigue induction. Using either CT, DN, or both combined is recommended to enhance the recovery of muscle functionality and properties, favoring recovery and potentially speeding up performance enhancement.
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  • 文章类型: Journal Article
    背景:肌筋膜疼痛综合征(MPS)是一种由称为肌筋膜触发点(MTrP)的肌肉内敏感压力区域引起的慢性疾病。
    目的:这项随机对照试验(RCT)的目的是评估与常规物理治疗相比,在慢性颈痛患者中增加干刺(DN)激活斜方肌上肌MTrP的有效性。
    方法:30名参与者从沙特阿拉伯的一家私人诊所招募。他们的平均年龄为29.7±4.4岁。将受试者随机分为两组:实验组(将DN应用于MTrP并进行常规理疗(n=15))和对照组(仅进行常规理疗(n=15))。主要结果是疼痛(使用视觉模拟量表评估)和残疾(颈部残疾指数),次要结局是颈部活动活动度(AROM;使用宫颈ROM评估)和抑郁(贝克抑郁量表).
    结果:干预后立即观察到疼痛强度的显著组间差异。实验组参与者的疼痛明显高于对照组(平均差异=1.27,95%置信区间[CI]0.20,2.33,p=0.022,Cohen'sd=0.889)。随访期间两组疼痛强度无显著差异。干预后立即残疾没有组间差异。然而,随访时的残疾存在组间差异;实验组参与者的残疾显著低于对照组(平均差异=-3.13,95CI-5.07,-1.20,p=0.003,Cohen\sd=1.211).立即干预后,与对照组相比,实验组显示出更大的屈曲AROM,与其他AROM措施没有差异。在后续行动中,实验组颈部AROM的伸展率明显较高,屈曲,右侧和左侧弯曲,降低抑郁,而两组间左右旋转AROMs无差异。
    结论:在标准物理治疗中加入DN可有效改善残疾,AROM(扩展名,屈曲,和侧面弯曲),慢性颈部疼痛患者的抑郁症。
    BACKGROUND: Myofascial pain syndrome (MPS) is a chronic condition caused by sensitive pressure regions within the muscles known as myofascial trigger points (MTrPs).
    OBJECTIVE: The purpose of this randomized controlled trial (RCT) was to assess the effectiveness of adding dry needling (DN) to activate MTrPs in the upper trapezius muscle compared with usual physiotherapy among individuals with chronic neck pain.
    METHODS: Thirty participants were recruited from a private clinic in Saudi Arabia. Their mean age was 29.7 ± 4.4 years. The subjects were randomized into two groups: the experimental group (application of DN to the MTrPs coupled with usual physiotherapy (n = 15)) and the control group (usual physiotherapy alone (n = 15)). The primary outcomes were pain (assessed using the visual analog scale) and disability (Neck Disability Index), and the secondary outcomes were neck active range of motion (AROM; assessed using cervical ROM) and depression (Beck\'s Depression Inventory).
    RESULTS: Significant between-group difference in pain intensity was observed immediately post-intervention. Participants in the experimental group had significantly higher pain (mean difference = 1.27, 95% confidence interval [CI] 0.20, 2.33, p = 0.022, Cohen\'s d = 0.889) than those in the control group. There was no significant difference between both groups in pain intensity during the follow-up. There were no between-group differences in disability immediately post-intervention. However, there was a between-group difference in disability at follow-up; participants in the experimental group had significantly lower disability (mean difference = -3.13, 95%CI -5.07, -1.20, p = 0.003, Cohen\'s d = 1.211) than those in the control group. Immediately post-intervention, the experimental group showed greater flexion AROM compared to the control group, with no differences in other AROM measures. At follow-up, the experimental group exhibited significantly higher neck AROM in extension, flexion, right and left side bending, and lower depression, while no differences were observed in right- and left-rotation AROMs between groups.
    CONCLUSIONS: The addition of DN to standard physiotherapy effectively improved disability, AROM (extension, flexion, and side bending), and depression among patients with chronic neck pain.
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  • 文章类型: Journal Article
    由于本体感觉和伤害性传入的变化,pop肌的肌筋膜疼痛综合征可能会改变受影响和相关肌肉的运动控制,这会加剧髌股疼痛综合征。本研究的主要目的是探索伴有继发性肌筋膜疼痛综合征的髌股疼痛综合征中膝关节局部和近端肌肉的肌电图活动,特别是在干针后影响pop肌。
    由于本体感受和伤害性传入的变化,pop肌的肌筋膜疼痛综合征可能会改变受影响和相关肌肉的运动控制,这会加剧髌股疼痛综合征。本研究的主要目的是探索伴有继发性肌筋膜疼痛综合征的髌股疼痛综合征中膝关节局部和近端肌肉的肌电图活动,特别是在干针后影响pop肌。
    在升压过程中,膝关节局部和近端肌肉的发作和偏移潜伏期,除了臀大肌的偏移潜伏期(p值=0.162),与对照组相比,干预组显着降低(p值<0.046)。此外,在步升和步降过程中,膝关节局部和近端肌肉的振幅比在各组之间没有显着差异(p值>0.116)。
    本研究表明,与股骨关节疼痛综合征相关的继发性肌筋膜疼痛综合征的干针法可建设性地改变步调过程中膝关节的局部和近端运动控制。
    UNASSIGNED: Myofascial pain syndrome in the popliteus muscle may change motor control in the affected and related muscles due to changes in proprioceptive and nociceptive afferents, which can exacerbate patellofemoral pain syndrome. The primary purpose of the current study was to explore the electromyographic activity of the local and proximal muscles of the knee joint in patellofemoral pain syndrome accompanied by secondary myofascial pain syndrome specifically affecting the popliteus muscle following dry needling.
    UNASSIGNED: Myofascial pain syndrome in the popliteus muscle may change motor control in the affected and related muscles due to changes in proprioceptive and nociceptive afferents, which can exacerbate patellofemoral pain syndrome. The primary purpose of the current study was to explore the electromyographic activity of the local and proximal muscles of the knee joint in patellofemoral pain syndrome accompanied by secondary myofascial pain syndrome specifically affecting the popliteus muscle following dry needling.
    UNASSIGNED: During step-up, the onset and offset latencies of the local and proximal muscles of the knee joint, except for the offset latency of the gluteus maximus muscle (p-value=0.162), significantly decreased in the intervention group compared to the control group (p-value<0.046). Additionally, there were no significant differences (p-value>0.116) between the groups in the amplitude ratio of the local and proximal muscles of the knee joint during both step-up and step-down.
    UNASSIGNED: The present study revealed that dry needling of the popliteus muscle with secondary myofascial pain syndrome associated with patellofemoral pain syndrome constructively modified the local and proximal motor control of the knee joint during step-up.
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  • 文章类型: Journal Article
    长头肱二头肌肌腱病,前肩疼痛的常见来源,可能导致不适和功能减弱。这项研究的目的是评估干刺和经皮神经电刺激对这些患者的疗效。
    30例患者随机分为干刺和经皮神经电刺激组,并在治疗前进行评估。治疗后8天和15天使用视觉模拟量表,肩痛和残疾指数,压力痛阈值,组织硬度,和肱二头肌周围积液。
    两种治疗方法均显着降低了视觉模拟评分(p<0.001),短期(p<0.01),和中期效应(p<0.01)。在短期和中期影响下,干针治疗肩痛和残疾指数分量表的疼痛(p<0.01)和残疾(p<0.03)优于经皮神经电刺激,分别。两种治疗后压力痛阈值均增加,但持续8天以上。两种治疗均未显示肱二头肌长头的组织硬度有任何改善。值得注意的是,在短期和中期效果上,只有干刺组显着减少了二头肌肌腱周围积液(p<0.01)。
    干刺在减轻疼痛和残疾方面的效果不劣于经皮神经电刺激,在减少肱二头肌肌腱周围积液方面的效果甚至更好(见图形摘要)。
    中国医科大学附属医院机构审查委员会(CMUH107-REC2-101)批准了这项研究,并在ClinicalTrials.gov上注册了标识符NCT03639454。
    干针刺和经皮神经电刺激均可有效减轻肱二头肌肌腱病的长头疼痛。干针法在短期和中期疼痛和残疾缓解方面优于经皮神经电刺激,分别。与经皮神经电刺激相比,干刺在减少二头肌肌腱周围积液方面表现出更好的效果。
    UNASSIGNED: Long head of biceps brachii tendinopathy, a frequent source of anterior shoulder pain, may lead to discomfort and diminished function. The objective of this study is to assess the efficacy of dry needling and transcutaneous electrical nerve stimulation in these patients.
    UNASSIGNED: Thirty patients were randomized into dry needling and transcutaneous electrical nerve stimulation groups and assessed before treatment, 8 and 15 days after treatment using a visual analogue scale, shoulder pain and disability index, pressure pain threshold, tissue hardness, and biceps peritendinous effusion.
    UNASSIGNED: Both treatments significantly reduced the visual analogue scale in immediate (p < 0.001), short-term (p < 0.01), and medium-term effects (p < 0.01). Dry needling outperformed transcutaneous electrical nerve stimulation for the pain (p < 0.01) and disability (p < 0.03) subscales of the shoulder pain and disability index in the short-term and medium-term effects, respectively. Pressure pain threshold increased after both treatments but didn\'t last beyond 8 days. Neither treatment showed any improvements in tissue hardness of the long head of biceps brachii muscle. Notably, only the dry needling group significantly reduced biceps peritendinous effusion in both short-term and medium-term effects (p < 0.01).
    UNASSIGNED: Dry needling showed non-inferior results to transcutaneous electrical nerve stimulation in reducing pain and disability and demonstrated even superior results in reducing biceps peritendinous effusion (see Graphical Abstract).
    UNASSIGNED: The Institutional Review Board of the China Medical University Hospital (CMUH107-REC2-101) approved this study, and it was registered with Identifier NCT03639454 on ClinicalTrials.gov.
    Both dry needling and transcutaneous electrical nerve stimulation effectively reduced pain in the long head of biceps brachii tendinopathy.Dry needling outperformed transcutaneous electrical nerve stimulation in short-term and medium-term pain and disability relief, respectively.Dry needling demonstrated superior results in reducing biceps peritendinous effusion compared to transcutaneous electrical nerve stimulation.
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  • 文章类型: Journal Article
    目的:比较Prolotherapy和深干针(DDN)联合治疗缓解颞下颌关节(TMJ)前盘移位症状的效果。
    方法:临床试验随机分配40名患者。(对照组)患者接受了四次关节内和咬肌DDN会话,而(研究组)患者接受了精确的技术,然后进行了Prolosolution注射。基线术前测量包括最大切缝开口(MIO),听诊点击的存在,和视觉模拟评分(VAS),一次后重复进行术后测量,两个,五,还有八个月.
    结果:在研究结束时,所有患者均表示疼痛MIO和咔嗒声明显改善。组间和组内比较显示,对照组在5个月和8个月后的疼痛评分值明显高于研究组。研究组MIO校准比对照组更显著,在任何时间间隔内,两组之间关于点击存在的差异都不显著。单击和VAS值之间的关联,在点击和MIO之间,在VAS值和MIO升高之间,试验组阳性,对照组阴性。
    结论:葡萄糖普罗疗法和DDN是有益的。然而,Prolotherapy证明更显著,持续,与症状的长期缓解和MIO增加相关。
    结论:该研究评估了除穿刺针的影响外,右旋糖修复疗法对缓解TMJ前椎间盘移位体征的唯一作用。
    背景:该研究在www上注册。
    结果:gov(#:NCT05821985),AhmedNagiAlghandour。
    OBJECTIVE: to compare the combined effect of Prolotherapy and Deep Dry Needling (DDN) versus DDN effect on relieving the symptoms of Temporomandibular joint (TMJ) anterior disc displacement.
    METHODS: The clinical trial randomly allocated forty patients. The (control group) patients received four intraarticular and masseteric DDN sessions, while the (study group) patients were subjected to the exact technique followed by Prolosolution injection. The baseline preoperative measurements included Maximal interincisal opening (MIO), auscultation of the presence of clicking, and Visual Analogue Scale (VAS), which were repeated for postoperative measurements after one, two, five, and eight months.
    RESULTS: By the end of the study, all patients expressed apparent improvement in pain MIO and clicking. The inter- and intragroup comparison revealed that the pain score values of the control group after five and eight months were significantly higher than those of the study group. The study group demonstrated more significant MIO calibration than the control group, with insignificant differences between both groups regarding the presence of clicking at any time interval. The associations between clicking and VAS values, between clicking and MIO, and between VAS values and increased MIO were positive in the test group and negative in the control group.
    CONCLUSIONS: Dextrose Prolotherapy and DDN were beneficial. However, Prolotherapy demonstrated more significant, sustained, and correlated long-term alleviation of symptoms and increased MIO.
    CONCLUSIONS: The study assesses the sole effect of dextrose prolotherapy on relieving the signs of TMJ anterior disc displacement apart from the impact of the penetrating needle.
    BACKGROUND: The study was registered on www.
    RESULTS: gov (#: NCT05821985) by Ahmed Nagi Alghandour.
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  • 文章类型: Journal Article
    胫骨内侧应力综合征(MTSS)也称为比目鱼肌综合征,因为由此产生的骨膜炎局限于比目鱼肌的内侧插入。本研究探讨了针对比目鱼肌筋膜触发点(MTrP)的干针(DN)在管理MTSS中的有效性。
    评估DN对患有MTSS的运动员的疼痛减轻和踝关节活动范围(ROM)改善的影响。
    这项随机对照试验(RCT)包括50名大学运动员。(DN组=25;对照组=25)。
    结果变量,疼痛,使用数字疼痛评定量表(NPRS)和通用测角仪测量踝关节背屈ROM,分别。该试验使用统计分析,如Wilcoxon秩检验用于组内比较,Mann-WhitneyU检验用于组间比较。该试验已在印度临床试验注册中心注册;CTRI/2023/10/058837。
    有24名女性(年龄=21.4±2.06)和26名男性(年龄=20.5±2.35)。DN显著降低了干预组的疼痛,从NPRS7±1.30降至2±0.87(p<0.001),但在对照组中,疼痛从NPRS7±0.99增加到7±1.05(p=0.009)。脚踝ROM没有改善。
    DN可在短期内有效缓解MTSS相关疼痛,但对改善踝关节ROM没有效果。
    UNASSIGNED: Medial tibial stress syndrome (MTSS) is also called soleus syndrome because the resultant periostitis is localized to the medial insertion of the soleus muscle. This study explores the effectiveness of dry needling (DN) targeting soleus myofascial trigger points (MTrPs) in managing MTSS.
    UNASSIGNED: To assess the impact of DN on pain reduction and ankle range of motion (ROM) improvement in athletes with MTSS.
    UNASSIGNED: This randomized controlled trial (RCT) included 50 university-level athletes. (DN group = 25; control group = 25).
    UNASSIGNED: Outcome variables, pain, and ankle dorsiflexion ROM were measured using the Numeric Pain Rating Scale (NPRS) and universal goniometer, respectively. The trial used statistical analyses like Wilcoxon rank test for within-group comparisons and Mann-Whitney U test for between-group comparisons. The trial was registered with the Clinical Trials Registry of India; CTRI/2023/10/058837.
    UNASSIGNED: There were 24 Females (Age = 21.4 ± 2.06) & 26 Males (Age = 20.5 ± 2.35). DN significantly reduced pain in the intervention group from NPRS 7 ± 1.30 to 2 ± 0.87 (p < 0.001), but in the control group, the pain increased from NPRS 7 ± 0.99 to 7 ± 1.05 (p = 0.009). There was no improvement in ankle ROM.
    UNASSIGNED: DN effectively alleviated MTSS-associated pain in the short-term but was not effective in improving ankle ROM.
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  • 文章类型: Journal Article
    目标:在当今的工业化世界中,百分之六十至百分之九十的劳动年龄人口经历腰背不适。慢性机械性腰背痛(CMLBP),当代工业社会劳动年龄人群中最常见的疾病,由于医疗服务的广泛使用和缺乏工作,造成了重大的经济负担。对于那些患有持续性机械性腰痛的人,本实验旨在评估短期使用针刺干针的疗效。
    方法:我们的研究包括30名患有非特异性下腰痛的个体,他们的年龄从20岁到45岁不等。使用随机方法将参与者分为两个平行组:A组中的15个人用干燥的针头放置在背部的指定位置进行针灸治疗,B组15人参加了肌肉强化和伸展运动。治疗前后,研究人员检查了四个方向的腰椎运动范围(ROM):屈曲,扩展,双侧侧弯曲,以及疼痛强度和功能障碍。
    结果:我们使用Shapiro-Wilk和Box检验检查数据的正态性和协方差同质性,分别。使用2x2混合设计-多变量方差分析(MANOVA),在各个测试组和测量周期中比较研究的感兴趣变量。我们使用0.05的显著性阈值。两组治疗后比较,发现屈曲和伸展运动范围显着增加(p<0.05),而疼痛的强度,向右和向左弯曲,功能损害显著减少(p<0.05)。多重成对比较结果显示疼痛严重程度有显著差异,功能衰弱,两组治疗前后的背部ROM(p<0.05),治疗后A组优于B组。
    结论:根据研究结果,通过缓解疼痛强度,干针针刺可能是治疗慢性机械性腰背痛的有益方式,改善功能衰弱,改进ROM。
    OBJECTIVE: In today\'s industrialized world, between sixty and ninety percent of the working-age population experiences low back discomfort. Chronic mechanical low back pain (CMLBP), the most common ailment among working-age people in contemporary industrial society, causes a major economic burden due to the widespread use of medical services and the absence of work. For those suffering from persistent mechanical low back pain, this experiment aimed to assess the efficacy of using acupuncture dry needles in the short term.
    METHODS: Our research included 30 individuals with nonspecific low back pain; their ages varied from 20 to 45. The participants were divided into two parallel groups using a random process: 15 individuals in group A had acupuncture treatment with a dry needle placed to specified locations on their backs, whereas 15 individuals in group B participated in muscle strengthening and stretching exercises. Both before and after therapy, researchers examined the lumbar range of motion (ROM) in four directions: flexion, extension, bilateral side bending, as well as pain intensity and functional impairment.
    RESULTS: We examined the data for normality and covariance homogeneity using the Shapiro-Wilk and Box\'s tests, respectively. The variables of interest that were investigated were compared across various test groups and measurement periods using a 2x2 mixed design-multivariate analysis of variance (MANOVA). We used a significance threshold of 0.05. When comparing the two groups after treatment, it was found that the flexion and extension range of motion increased significantly (p<0.05), while the pain intensity, bending to the right and left, and functional impairment decreased significantly (p<0.05). The results of multiple pairwise comparisons showed a noteworthy difference in pain severity, functional debility, and back ROM between the two groups before and after treatment (p<0.05), with group A showing an advantage over group B after treatment.
    CONCLUSIONS: Based on the study results, dry needle acupuncture may be a beneficial modality in treating chronic mechanical low back pain by relieving pain intensity, improving functional debility, and improving ROM.
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  • 文章类型: Journal Article
    这项研究旨在研究潜在的安慰剂和nocebo效应对经皮针头电解(PNE)的疼痛感知的影响。
    在这项对三臂随机双盲对照试验的二次分析中,本研究调查了48名18~45岁髌腱病运动参与者的会中和会期疼痛感知数据.参与者分为3个平行组:“无假组”[PNE干预],“单假手术组”[使用干针刺进行假手术],和“双假手术组”[使用假针进行假手术]。每组在8周内接受4次针对the肌腱的针刺疗法,并被指示对患侧的股四头肌进行单侧偏心运动程序。临床和针头相关的疼痛进行评估之前,during,并在每次治疗后使用视觉模拟量表。
    两组间在疼痛减轻方面没有发现差异(P=0.424),尽管自第一次治疗以来所有组的临床疼痛均有所减轻(P<0.001)。此外,尽管双假手术组显示在针头干预期间报告针头相关疼痛的参与者百分比较低(P=0.005),两组间针刺干预后针刺相关疼痛强度相似(P=0.682).此外,任何针刺干预后疼痛感觉的持续时间没有组间差异(P=0.184),在许多情况下超过24小时。
    髌腱病患者的针刺疗法容易引起临床疼痛的安慰剂效应和针刺相关疼痛的无效应。治疗肌肉骨骼疼痛的临床医生和物理治疗师在常规使用针头技术之前,应考虑附加值和潜在的作用机制。
    UNASSIGNED: This study aimed to investigate the influence of potential placebo and nocebo effects on pain perception of percutaneous needle electrolysis (PNE) in individuals with patellar tendinopathy.
    UNASSIGNED: In this secondary analysis of a three-arm randomized double-blinded controlled trial, intra and inter-session pain perception data from 48 sporting participants with patellar tendinopathy between 18 and 45 years were investigated. Participants were divided into 3 parallel groups: \"no-sham group\" [PNE intervention], \"single-sham group\" [sham PNE by using dry needling], and \"double-sham group\" [sham PNE by using sham needles]. Every group received 4 sessions of the needling therapies targeting the patellar tendon over 8 weeks and was instructed to perform a unilateral eccentric exercise program of the quadriceps muscle on the affected side. Clinical and needle-related pain was assessed before, during, and after each treatment session using a visual analog scale.
    UNASSIGNED: No differences were found between groups intra- or inter-session in terms of pain reduction (P = 0.424) despite clinical pain decreased in all groups since the first treatment session (P < 0.001). Furthermore, although the double-sham group showed a lower percentage of participants reporting needle-related pain during needle intervention (P = 0.005), the needle-related pain intensity after needle intervention was similar between groups (P = 0.682). Moreover, there were no group differences for the duration of pain sensation after any needle intervention (P = 0.184), extending in many cases beyond 24 h.
    UNASSIGNED: Needling therapies for individuals with patellar tendinopathy are prone to elicit placebo effects regarding clinical pain and nocebo effects regarding needling-related pain. Clinicians and physical therapists treating musculoskeletal pain conditions should consider the added value and potential mechanisms of action before routinely using needle techniques.
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  • 文章类型: Journal Article
    神经调节可能是干针(DN)的潜在机制之一;然而,该机制尚未完全阐明。
    这项随机对照试验旨在评估慢性踝关节不稳定(CAI)和健康受试者对胫骨前肌和腓骨长肌的DN刺激,使用功能磁共振成像(fMRI)。
    临床研究方案,符合SPIRIT标准。
    大脑标测实验室。
    本研究将包括30名年龄在18至40岁之间的参与者。将20名健康参与者随机分为2组(真实DN和假DN)。还将招募10名CAI患者进入第三组,仅接受真实DN进行比较。
    真实和假DN。
    体素数,峰值激活的坐标,和峰值强度将作为报告脑图激活的主要结果。测量将在之前进行,during,DN治疗后。踝关节背屈肌的力量,主动背屈运动范围,麦吉尔疼痛问卷简式将用作次要结局指标。
    这项研究的结果将在同行评审的期刊上发表,并在国内和国际大会上作为演讲进行传播。
    这项试验将探索健康参与者对真实和假DN的大脑反应以及CAI患者对真实DN的反应。总的来说,我们的研究结果将为DN的神经机制提供初步证据。
    UNASSIGNED: Neuromodulation may be one of the underlying mechanisms of dry needling (DN); however, the mechanism has not yet been fully clarified.
    UNASSIGNED: This randomized controlled trial is designed to evaluate DN stimulation of the tibialis anterior and peroneus longus muscles in chronic ankle instability (CAI) and healthy subjects, employing functional magnetic resonance imaging (fMRI).
    UNASSIGNED: Clinical study protocol, SPIRIT compliant.
    UNASSIGNED: Brain Mapping Laboratory.
    UNASSIGNED: A total of thirty participants aged between 18 and 40 years old will be included in this study. Twenty healthy participants will be randomized into 2 groups (real DN and sham DN). Ten patients with CAI will also be recruited to the third group and receive only real DN for comparison.
    UNASSIGNED: Real and sham DN.
    UNASSIGNED: The voxel count, coordinates of peak activation, and peak intensity will be obtained as primary outcomes to report brain map activation. Measurements will be taken before, during, and after DN treatment. The strength of the ankle dorsiflexors, active dorsiflexion range of motion, and McGill pain questionnaire short-form will be used as secondary outcome measures.
    UNASSIGNED: The results from this study will be published in peer-reviewed journals and disseminated as presentations at national and international congresses.
    UNASSIGNED: This trial will explore brain responses to real and sham DN in healthy participants and to real DN in CAI patients. Overall, our results will provide preliminary evidence of the neural mechanism of DN.
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  • 文章类型: Journal Article
    背景:血管性认知障碍(VCI)持续损害认知和进行日常生活活动的能力,严重影响患者的生活质量。先前的研究报道,血清铁代谢紊乱和大脑中铁沉积可导致炎症,异常的蛋白质聚集和变性,中枢神经系统大量神经元凋亡,这反过来又导致认知过程的逐步下降。我们之前的临床研究发现针灸治疗VCI是一种安全有效的干预措施,但具体机制有待进一步探索。
    目的:本试验旨在评价通都醒神针刺法的临床疗效,探讨其是否能通过调节脑铁沉积和机体铁代谢来改善VCI。
    方法:总共,42名VCI患者和21名健康个体将参与这项临床试验。将42例VCI患者随机分为针刺组和对照组,而21名健康个体将进入健康对照组。对照组和针刺组均接受常规药物治疗和认知康复训练。此外,针刺组用通度醒神电针治疗,每次30分钟,每周6次,共4周。同时,健康对照组将不接受任何干预。所有3组将接受脑铁沉积的基线评估,血清铁代谢,和入学后的神经心理学测试。针灸组和对照组将在治疗4周结束时再次进行评估,如前所述。通过比较各组之间的神经心理学测试成绩,我们将研究通都醒神针刺治疗VCI的疗效。此外,我们将测试神经心理学测试成绩之间的相关性,脑铁沉积,及机体铁代谢指标,探讨通毒醒神针刺治疗VCI的可能机制。
    结果:目前正在招募参与者。第一位参与者于2023年6月注册,这标志着实验的正式开始。截至论文提交之时,有23人参加。招聘过程预计将持续到2025年6月,届时将开始处理和分析数据。截至2024年5月15日,多达30人参加了这项临床试验。
    结论:本研究将提供通都醒神针刺对VCI患者脑铁沉积以及躯体铁代谢的影响。这些结果将有助于证明通都醒神针法能否通过调节脑铁沉积和机体铁代谢来改善VCI,为针灸疗法在VCI康复中的广泛应用提供临床和理论依据。
    背景:中国临床注册管理机构ChiCTR2300072188;https://tinyurl.com/5fcydtkv.
    PRR1-10.2196/56484。
    BACKGROUND: Vascular cognitive impairment (VCI) persistently impairs cognition and the ability to perform activities of daily living, seriously compromising patients\' quality of life. Previous studies have reported that disorders of serum iron metabolism and iron deposition in the brain can lead to inflammation, abnormal protein aggregation and degeneration, and massive neuronal apoptosis in the central nervous system, which in turn leads to a progressive decline in cognitive processes. Our previous clinical studies have found acupuncture to be a safe and effective intervention for treating VCI, but the specific mechanisms require further exploration.
    OBJECTIVE: The objective of the trial is to evaluate the clinical efficacy of Tongdu Xingshen acupuncture and to investigate whether it can improve VCI by regulating brain iron deposition and body iron metabolism.
    METHODS: In total, 42 patients with VCI and 21 healthy individuals will participate in this clinical trial. The 42 patients with VCI will be randomized into acupuncture and control groups, while the 21 healthy individuals will be in the healthy control group. Both the control and acupuncture groups will receive conventional medical treatment and cognitive rehabilitation training. In addition, the acupuncture group will receive electroacupuncture treatment with Tongdu Xingshen for 30 minutes each time, 6 times a week for 4 weeks. Meanwhile, the healthy control group will not receive any intervention. All 3 groups will undergo baseline assessments of brain iron deposition, serum iron metabolism, and neuropsychological tests after enrollment. The acupuncture and control groups will be evaluated again at the end of 4 weeks of treatment, as described earlier. By comparing neuropsychological test scores between groups, we will examine the efficacy of Tongdu Xingshen acupuncture in treating VCI. Additionally, we will test the correlations between neuropsychological test scores, brain iron deposition, and body iron metabolism indexes to explore the possible mechanisms of Tongdu Xingshen acupuncture in treating VCI.
    RESULTS: Participants are currently being recruited. The first participant was enrolled in June 2023, which marked the official start of the experiment. As of the submission of the paper, there were 23 participants. The recruitment process is expected to continue until June 2025, at which point the processing and analysis of data will begin. As of May 15, 2024, up to 30 people have been enrolled in this clinical trial.
    CONCLUSIONS: This study will provide data on the effects of Tongdu Xingshen acupuncture on cerebral iron deposition as well as somatic iron metabolism in patients with VCI. These results will help to prove whether Tongdu Xingshen acupuncture can improve VCI by regulating brain iron deposition and body iron metabolism, which will provide the clinical and theoretical basis for the wide application of acupuncture therapy in VCI rehabilitation.
    BACKGROUND: China Clinical Registration Agency ChiCTR2300072188; https://tinyurl.com/5fcydtkv.
    UNASSIGNED: PRR1-10.2196/56484.
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