dermatologists

皮肤科医生
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  • 文章类型: Journal Article
    背景:患者报告的结果与临床实践相关,显示患者的益处,支持临床医生的决策,并有助于提供高标准的护理。对患者报告的结果进行数字监测仍然很少见。患者获益指数(PBI)衡量患者观点的获益和目标,可能与定期记录和共同决策相关。
    目的:本研究旨在开发PBI的电子版,以检查其在银屑病患者临床实践中的可行性和可接受性。
    方法:我们开发了一个应用程序,在对其可行性和可接受性进行定量调查之前,使用焦点小组和对患者的认知汇报进行有效的PBI。Conduction参加了德国的门诊皮肤科护理室。进行描述性和亚组分析。
    结果:共有139名患者完成了电子PBIs(ePBIs)并参与了调查。ePBI是可以理解的(n=129-137,92.8%-98.6%)和可行的,例如,易于阅读(n=135,97.1%)和简单处理(n=137,98.5%)。可接受性也很高,例如,患者可以想象在实践中使用和讨论ePBI数据(n=91,65.5%)并定期记录(n=88,63.3%).他们认为它可以支持治疗决策(n=118,84.9%)并改善与医生的沟通(n=112,81.3%)。他们可以想象定期填写电子问卷(n=118,84.9%),甚至更喜欢电子版本而不是纸质版本(n=113,81.2%)。年龄较大和受教育程度较低的人表现出更小的可行性,但是后者希望与医生的关系得到改善,并且更愿意投入时间或精力。
    结论:PBI的应用程序和网络版本对于提供全面文档和患者参与实践的患者是可用和可接受的。实施策略应考虑患者的需求,障碍,和促进者,还有医生的态度和医疗保健系统的要求。
    BACKGROUND: Patient-reported outcomes are relevant in clinical practice showing patient benefits, supporting clinicians\' decision-making, and contributing to the delivery of high standards of care. Digital monitoring of patient-reported outcomes is still rare. The Patient Benefit Index (PBI) measures benefits and goals from patients\' views and may be relevant for regular documentation and shared decision-making.
    OBJECTIVE: This study aimed to develop electronic versions of the PBI to examine their feasibility and acceptability in clinical practice for patients with psoriasis.
    METHODS: We developed an app and a web version of the existing, valid PBI using focus groups and cognitive debriefings with patients before conducting a quantitative survey on its feasibility and acceptability. Conduction took part in an outpatient dermatology care unit in Germany. Descriptive and subgroup analyses were conducted.
    RESULTS: A total of 139 patients completed the electronic PBIs (ePBIs) and took part in the survey. The ePBI was understandable (n=129-137, 92.8%-98.6%) and feasible, for example, easy to read (n=135, 97.1%) and simple to handle (n=137, 98.5%). Acceptability was also high, for example, patients can imagine using and discussing the ePBI data in practice (n=91, 65.5%) and documenting it regularly (n=88, 63.3%). They believe it could support treatment decisions (n=118, 84.9%) and improve communication with their physician (n=112, 81.3%). They can imagine filling in electronic questionnaires regularly (n=118, 84.9%), even preferring electronic over paper versions (n=113, 81.2%). Older and less educated people show less feasibility, but the latter expected the relationship with their physician to improve and would be more willing to invest time or effort.
    CONCLUSIONS: The app and web version of the PBI are usable and acceptable for patients offering comprehensive documentation and patient participation in practice. An implementation strategy should consider patients\' needs, barriers, and facilitators but also physicians\' attitudes and requirements from the health care system.
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  • 文章类型: Journal Article
    对特应性皮炎(AD)成人和治疗AD成人的医生的真实世界治疗满意度的研究很少。我们试图描述成人AD患者的治疗满意度和医生对AD治疗的患者满意度。我们对>=18岁的成年人进行了横断面研究(修改后的AD英国工作组标准,年龄发病<=18[N=767])与AD和过敏症专家/免疫学家之间的平行医师调查[N=148],皮肤科医生[N=149]和初级保健医学[N=104]。使用Logistic回归模型来检查与患者治疗满意度(PTS)或医生感知的患者治疗满意度(pPTS)相关的因素。与PTS增加相关的因素包括女性,年龄较大,并接受书面湿疹行动计划(EAP)。重度AD,痒,疼痛,失眠,对合作伙伴关系的影响更大,感觉没有充分了解AD原因,被分开,从未结过婚,或与伴侣一起生活与PTS减少有关。从医生的角度来看,轻度AD和EAP的发展与pPTS的增加有关,而在实践中更长的时间与更少的pPTS相关。限制包括AD错误分类的可能性和无法将AD患者与个体医师匹配。认识到哪些因素与治疗满意度相关,可以帮助告知咨询和决策策略。包括使用湿疹行动计划,并支持患者-医师结果一致。
    Studies examining the real-world treatment satisfaction in adults with atopic dermatitis (AD) and the physicians who treat adults with AD are scarce. We sought to characterize treatment satisfaction of adults with AD and physicians\' perceived patient satisfaction with AD treatment. We performed a cross-sectional study of adults > = 18 years of age (modified AD UK Working Party Criteria, age onset < = 18 [N = 767]) with AD and a parallel-physician survey among allergists/immunologists [N = 148], dermatologists [N = 149] and primary care medicine [N = 104]. Logistic regression models were used to examine factors associated with patient treatment satisfaction (PTS) or physician-perceived patient treatment satisfaction (pPTS). Factors associated with increased PTS included female, older age, and receiving a written eczema action plan (EAP). Severe AD, itch, pain, and insomnia, greater impact on partner relationships, feeling not adequately informed about AD causes, and being separated, never married, or living with a partner was associated with less PTS. From the physician\'s perspective, mild AD and development of EAP was associated with increase pPTS, whereas being in practice longer was associated with less pPTS. Limitations include the potential for misclassification of AD and the inability to match AD patients to individual physicians. Recognizing which factors are associated with treatment satisfaction can help inform counseling and decision-making strategies, including the use of an eczema action plan, and support patient-physician outcomes alignment.
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  • 文章类型: Journal Article
    背景:难以获得皮肤病学咨询是黑色素瘤早期诊断的障碍。一方面,患者的生存取决于诊断时的病变厚度。另一方面,皮肤科医生治疗许多良性病变患者。优化患者护理路径是一个主要问题。本研究的目的是评估全科医生(GP)和皮肤科医生之间可疑黑色素瘤病变照片的电子邮件传输是否可以减少对可疑皮肤病变最终需要切除的患者进行皮肤科咨询的时间。
    方法:我们在2017年4月至2019年8月期间,在51名法国全科医生的初级保健中进行了一项集群随机对照研究。共有250例因疑似黑色素瘤病变而转诊给皮肤科医生的患者被纳入全科医生,被随机分配到智能手机手臂或常规护理手臂。在智能手机的手臂,全科医生通过使用智能手机发送2张可疑病变的照片,将患者转介给皮肤科医生.然后,皮肤科医生不得不在适当的时间安排预约。在通常的护理臂中,全科医生根据他们的惯例将患者转介给皮肤科医生。主要结果是最终需要切除病变的患者的皮肤病学咨询时间。
    结果:57名自愿参加的全科医生被随机分配(27名到智能手机部门,和30到通常的护理臂)。每组共纳入125名患者(平均年龄:49.8岁;53%为女性),随访8个月。23名皮肤科医生参与了这项研究。对于需要切除可疑皮肤病变的患者,其皮肤科咨询时间在智能手机臂中为56.5天,在常规护理臂中为63.7天(平均调整时间减少:-18.5天,95%CI[-74.1;23.5],p=.53)。
    结论:从全科医生向皮肤科医生发送照片的电子邮件并没有改善可疑皮肤病变最终需要切除的患者的皮肤科管理。需要进一步的研究来验证可能对皮肤病学远程专业知识有用的质量标准。
    背景:在ClinicalTrials.gov上注册,参考号为NCT03137511(2017年5月2日)。
    BACKGROUND: Difficulty obtaining a dermatological consultation is an obstacle to the early diagnosis of melanoma. On the one hand, patients survival depends on the lesion thickness at the time of diagnosis. On the other hand, dermatologists treat many patients with benign lesions. Optimizing patient care pathways is a major concern. The aim of the present study was to assess whether the e-mail transmission of photographs of suspected melanoma lesions between general practitioners (GPs) and dermatologists reduces the time to dermatological consultation for patients whose suspicious skin lesions ultimately require resection.
    METHODS: We conducted a cluster-randomized controlled study in primary care involving 51 French GPs between April 2017 and August 2019. A total of 250 patients referred to a dermatologist for a suspected melanoma lesion were included GPs were randomized to either the smartphone arm or the usual care arm. In the smartphone arm, the GPs referred patients to the dermatologist by sending 2 photographs of the suspicious lesion using their smartphone. The dermatologist then had to set up an appointment at an appropriate time. In the usual care arm, GPs referred patients to a dermatologist according to their usual practice. The primary outcome was the time to dermatological consultation for patients whose lesion ultimately required resection.
    RESULTS: 57 GPs volunteered were randomized (27 to the smartphone arm, and 30 to the usual care arm). A total of 125 patients were included in each arm (mean age: 49.8 years; 53% women) and followed 8 months. Twenty-three dermatologists participated in the study. The time to dermatological consultation for patients whose suspicious skin lesion required resection was 56.5 days in the smartphone arm and 63.7 days in the usual care arm (mean adjusted time reduction: -18.5 days, 95% CI [-74.1;23.5], p = .53).
    CONCLUSIONS: The e-mail transmission of photographs from GPs to dermatologists did not improve the dermatological management of patients whose suspicious skin lesions ultimately required resection. Further research is needed to validate quality criteria that might be useful for tele-expertise in dermatology.
    BACKGROUND: Registered on ClinicalTrials.gov under reference number NCT03137511 (May 2, 2017).
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  • 文章类型: Journal Article
    背景:皮肤科患者教育材料(PEM)的书写水平通常高于全国平均水平的七至八年级阅读水平。ChatGPT-3.5,GPT-4,DermGPT,和DocsGPT是响应用户提示的大型语言模型(LLM)。我们的项目评估了它们在指定阅读水平下生成皮肤病学PEM的用途。
    目的:本研究旨在评估在未指定和指定的阅读水平下,选择LLM在常见和罕见皮肤病学中产生PEM的能力。Further,该研究旨在评估这些LLM生成的PEM的意义保存情况,由皮肤科住院医师评估。
    方法:当前美国皮肤病学会PEMs的Flesch-Kincaid阅读水平(FKRL)评估了4种常见(特应性皮炎,寻常痤疮,牛皮癣,和带状疱疹)和4例罕见(大疱性表皮松解症,大疱性类天疱疮,层状鱼鳞病,和扁平苔藓)皮肤病。我们提示ChatGPT-3.5,GPT-4,DermGPT,和DocsGPT以“在[FKRL]中创建关于[条件]的患者教育讲义”,以在未指定的五年级和七年级FKRL中每个条件迭代生成10个PEM,使用MicrosoftWord可读性统计进行评估。由2名皮肤科住院医师评估了LLM中意义的保留。
    结果:当前的美国皮肤病学会PEMs对常见和罕见疾病的平均(SD)FKRL为9.35(1.26)和9.50(2.3),分别。对于常见疾病,LLM生产的PEM的FKRL介于9.8和11.21之间(未指定提示),在4.22和7.43之间(五年级提示),在5.98和7.28之间(七年级提示)。对于罕见疾病,LLM生产的PEM的FKRL范围在9.85和11.45之间(未指定提示),在4.22和7.43之间(五年级提示),在5.98和7.28之间(七年级提示)。在五年级阅读水平,与ChatGPT-3.5相比,GPT-4在常见和罕见条件下都能更好地生产PEM(分别为P=.001和P=.01),DermGPT(分别为P<.001和P=.03),和DocsGPT(分别为P<.001和P=.02)。在七年级的阅读水平,ChatGPT-3.5、GPT-4、DocsGPT、或DermGPT在生产常见条件下的PEM(所有P>.05);然而,对于罕见的情况,ChatGPT-3.5和DocsGPT的表现优于GPT-4(分别为P=.003和P<.001)。意义分析的保留表明,对于共同条件,DermGPT在整体阅读便利性方面排名最高,患者的可理解性,和准确性(14.75/15,98%);对于罕见的情况,GPT-4产生的施舍排名最高(14.5/15,97%)。
    结论:GPT-4的表现似乎优于ChatGPT-3.5,DocsGPT,和DermGPT在五年级FKRL的常见和罕见的情况下,尽管ChatGPT-3.5和DocsGPT在7级FKRL中在罕见情况下的表现均优于GPT-4。LLM生产的PEM可以可靠地满足七级FKRL的选择常见和罕见的皮肤病,并且易于阅读,患者可以理解,而且大多是准确的。LLM可能在提高健康素养和传播无障碍方面发挥作用,在皮肤病学中可以理解的PEM。
    BACKGROUND: Dermatologic patient education materials (PEMs) are often written above the national average seventh- to eighth-grade reading level. ChatGPT-3.5, GPT-4, DermGPT, and DocsGPT are large language models (LLMs) that are responsive to user prompts. Our project assesses their use in generating dermatologic PEMs at specified reading levels.
    OBJECTIVE: This study aims to assess the ability of select LLMs to generate PEMs for common and rare dermatologic conditions at unspecified and specified reading levels. Further, the study aims to assess the preservation of meaning across such LLM-generated PEMs, as assessed by dermatology resident trainees.
    METHODS: The Flesch-Kincaid reading level (FKRL) of current American Academy of Dermatology PEMs was evaluated for 4 common (atopic dermatitis, acne vulgaris, psoriasis, and herpes zoster) and 4 rare (epidermolysis bullosa, bullous pemphigoid, lamellar ichthyosis, and lichen planus) dermatologic conditions. We prompted ChatGPT-3.5, GPT-4, DermGPT, and DocsGPT to \"Create a patient education handout about [condition] at a [FKRL]\" to iteratively generate 10 PEMs per condition at unspecified fifth- and seventh-grade FKRLs, evaluated with Microsoft Word readability statistics. The preservation of meaning across LLMs was assessed by 2 dermatology resident trainees.
    RESULTS: The current American Academy of Dermatology PEMs had an average (SD) FKRL of 9.35 (1.26) and 9.50 (2.3) for common and rare diseases, respectively. For common diseases, the FKRLs of LLM-produced PEMs ranged between 9.8 and 11.21 (unspecified prompt), between 4.22 and 7.43 (fifth-grade prompt), and between 5.98 and 7.28 (seventh-grade prompt). For rare diseases, the FKRLs of LLM-produced PEMs ranged between 9.85 and 11.45 (unspecified prompt), between 4.22 and 7.43 (fifth-grade prompt), and between 5.98 and 7.28 (seventh-grade prompt). At the fifth-grade reading level, GPT-4 was better at producing PEMs for both common and rare conditions than ChatGPT-3.5 (P=.001 and P=.01, respectively), DermGPT (P<.001 and P=.03, respectively), and DocsGPT (P<.001 and P=.02, respectively). At the seventh-grade reading level, no significant difference was found between ChatGPT-3.5, GPT-4, DocsGPT, or DermGPT in producing PEMs for common conditions (all P>.05); however, for rare conditions, ChatGPT-3.5 and DocsGPT outperformed GPT-4 (P=.003 and P<.001, respectively). The preservation of meaning analysis revealed that for common conditions, DermGPT ranked the highest for overall ease of reading, patient understandability, and accuracy (14.75/15, 98%); for rare conditions, handouts generated by GPT-4 ranked the highest (14.5/15, 97%).
    CONCLUSIONS: GPT-4 appeared to outperform ChatGPT-3.5, DocsGPT, and DermGPT at the fifth-grade FKRL for both common and rare conditions, although both ChatGPT-3.5 and DocsGPT performed better than GPT-4 at the seventh-grade FKRL for rare conditions. LLM-produced PEMs may reliably meet seventh-grade FKRLs for select common and rare dermatologic conditions and are easy to read, understandable for patients, and mostly accurate. LLMs may play a role in enhancing health literacy and disseminating accessible, understandable PEMs in dermatology.
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    背景:社交媒体培育了一种趋势,理想,美容标准也显著提高。完美无瑕的皮肤图像,雕刻的特征,和策划美学淹没用户供稿,潜在地塑造他们的自我认知和抱负。影响者的崛起,皮肤科医生社交媒体参与,分享护肤程序和产品推荐的美容活动对个人外观相关的决定产生了重大影响。
    目的:本研究的主要目的是确定使用社交媒体寻求皮肤病学程序和皮肤护理常规的行为模式。
    方法:我们在全国范围内进行了一次,针对沙特总人口的在线横断面研究。我们的调查旨在了解参与者的社交媒体行为并收集对护肤产品的见解,美容程序,和化妆习惯。
    结果:在寻求护肤建议时出现了与性别相关的差异。女性更喜欢社交媒体上的皮肤科医生(p<0.001)和美容影响者(p<0.001),而男性倾向于药剂师(p<0.001)。女性在非化妆品方面表现出更强的参与皮肤科医生社交媒体声誉(p<0.001),教育(p<0.001),和社交媒体对化妆品决策的影响(p=0.001)。他们经常在约会前在社交媒体上寻找皮肤科医生(p=0.001),而男性强调皮肤科医生的名声(p=0.024)。常见的化妆品障碍包括高成本(62.5%),并发症(40.3%),和信任问题(40.2%)。女性接受了各种整容手术(p<0.05),在他们的决定和护肤程序中受到社交媒体的影响。
    结论:我们的研究揭示了在寻求护肤建议方面存在显著的性别差异。女性依赖社交媒体,诊所,朋友,和美丽的影响者,而男人更喜欢药剂师。此外,女性依赖皮肤科医生的社交媒体声誉,并进行全面的预约前研究。他们增强的社交媒体参与度与护肤实践联系在一起,并根据年龄和使用频率影响整容手术的考虑因素。
    BACKGROUND: Social media has fostered a landscape where trends, ideals, and beauty standards have significantly proliferated. Images of flawless skin, sculpted features, and curated aesthetics inundate user feeds, potentially shaping their self-perceptions and aspirations. The rise of influencers, dermatologist social media engagement, and beauty campaigns sharing skincare routines and product recommendations wield substantial influence over individual appearance-related decisions.
    OBJECTIVE: The main aim of this study is to determine the pattern of behavior in using social media to seek dermatological procedures and skin care routine.
    METHODS: We conducted a nationwide, online cross-sectional study targeting the general Saudi population. Our survey aimed to understand participant social media behaviors and gather insights into skincare products, cosmetic procedures, and makeup habits.
    RESULTS: Gender-related differences emerged in seeking skincare advice. Females preferred dermatologists on social media (p < 0.001) and beauty influencers (p < 0.001), whereas men leaned towards pharmacists (p < 0.001). Women displayed stronger engagement with dermatologist social media reputation regarding non-cosmetic concerns (p < 0.001), education (p < 0.001), and social media impact on cosmetic decisions (p = 0.001). They frequently sought dermatologists on social media before appointments (p = 0.001), whereas men emphasized dermatologists\' fame (p = 0.024). Common cosmetic barriers included high costs (62.5%), complications (40.3%), and trust issues (40.2%). Women underwent various cosmetic procedures (p < 0.05), influenced by social media in their decisions and skincare routines.
    CONCLUSIONS: Our study reveals significant gender-based disparities in seeking skincare advice. Women rely on social media, clinics, friends, and beauty influencers, whereas men prefer pharmacists. Additionally, women depend on dermatologists\' social media reputation and conduct thorough pre-appointment research. Their heightened social media engagement links to skincare practices and influences cosmetic procedure considerations based on age and usage frequency.
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  • 文章类型: Journal Article
    实时视频会议(LVC)远程皮肤病学的诊断准确率,由董事会认证的皮肤科医生与非皮肤科医生相比,尚未得到充分调查。这项研究的目的是比较认证的皮肤科医生的诊断准确性,皮肤科专业学员,和LVC远程皮肤病学的董事会认证内科医生。我们检查了来自不同专业的临床医生在诊断同一组患者时的诊断准确性。在诊断过程中,临床医生彼此隔离。我们招募了18名志愿者医生(6名委员会认证的皮肤科医生,六名皮肤科专业学员,和六名经过董事会认证的内科医生),他们通过LVC远程皮肤科检查了18名患者的皮肤状况。使用最终诊断作为参考标准来评估参与医师的诊断准确性。根据医生的专业和疾病类别比较诊断准确性平均值。最详细水平诊断的均值±标准差诊断准确率为83.3%±3.5%(范围,77.8%-89.0%)为董事会认证的皮肤科医生,皮肤科专业学员53.7±20.7%(范围27.8%-77.8%),和27.8±5.0%(范围,22.2%-33.3%)为董事会认证的内科医生。董事会认证的皮肤科医生显示出明显更高的诊断准确性,不仅针对董事会认证的内科医生(p<0.0001),而且还针对皮肤科专业学员(p<0.05)。只有经过董事会认证的皮肤科医生才能获得高准确率(≥80%)的疾病类别是炎性丘疹鳞状皮肤病(87.5%),与58.3%相比,皮肤科专业学员和董事会认证的内科医生分别为20.8%)。对于炎症性红斑和其他反应性炎症性皮肤病,董事会认证的皮肤科医生的准确率,皮肤科专业学员,董事会认证的内科医生占83.3%,33.3%,分别为8.3%;对于黑色素瘤原位肿瘤,83.3%,50.0%,分别为66.7%),角质化的遗传性疾病占83.3%,33.3%,分别为0%)。我们的发现表明,经过董事会认证的皮肤科医生可能具有很高的诊断准确性,并且在LVC远程皮肤科中具有实际的安全性和有效性。
    The diagnostic accuracy rate of live videoconferencing (LVC) teledermatology, by board-certified dermatologists compared to non-dermatologists has not yet been fully investigated. The aim of this study was to compare the diagnostic accuracy of board-certified dermatologists, dermatology specialty trainees, and board-certified internists in LVC teledermatology. We examined the diagnostic accuracy of clinicians from different specialties in diagnosing the same group of patients. The clinicians were isolated from each other during the diagnosis process. We enrolled 18 volunteer physicians (six board-certified dermatologists, six dermatology specialty trainees, and six board-certified internists) who reviewed the skin conditions of 18 patients via LVC teledermatology. The diagnostic accuracy of the participating physicians was evaluated using the final diagnosis as the reference standard. The diagnostic accuracy averages were compared according to the physicians\' specialties and disease categories. The mean ± standard deviation diagnostic accuracy of the most detailed level diagnosis was 83.3% ± 3.5% (range, 77.8%-89.0%) for board-certified dermatologists, 53.7 ± 20.7% (range 27.8%-77.8%) for dermatology specialty trainees, and 27.8 ± 5.0% (range, 22.2%-33.3%) for board-certified internists. Board-certified dermatologists showed significantly higher diagnostic accuracy, not only against board-certified internists (p < 0.0001) but also against dermatology specialty trainees (p < 0.05). Disease categories with high accuracy rates (≥80%) only by board-certified dermatologists were inflammatory papulosquamous dermatoses (87.5%), compared to 58.3%, and 20.8% for dermatology specialty trainees and board-certified internists respectively). For inflammatory erythemas and other reactive inflammatory dermatoses the accuracy rates for board-certified dermatologists, dermatology specialty trainees, and board-certified internists were 83.3%, 33.3%, 8.3% respectively; for melanoma in situ neoplasms, 83.3%, 50.0%, 66.7% respectively), and for genetic disorders of keratinization 83.3%, 33.3%, and 0% respectively). Our findings showed that board-certified dermatologists may have high diagnostic accuracy with practical safety and effectiveness in LVC teledermatology.
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  • 文章类型: Journal Article
    目的:生物疗法已导致越来越多的牛皮癣患者拥有透明或接近透明的皮肤。目前的做法是在这些患者中无限期地继续进行生物治疗,造成了巨大的长期药物和医疗保健负担。根据需要,牛皮癣的生物治疗可以解决这个问题,然而,我们对患者和临床医生对此策略的理解有限.
    方法:我们首先在英国范围内对银屑病患者和皮肤科临床医生进行了在线范围调查,以探讨他们对“视需要”生物治疗的看法。使用这些调查结果提供的主题指南,然后,我们对患者和临床医师进行了定性焦点分组.使用反身主题分析确定主题。
    结果:在完成范围调查的67名患者和27名临床医生中,67%(43/64)和78%(21/27),分别,支持根据需要使用\'生物治疗。受访者强调了诸如减轻医疗保健负担和更大的护理所有权等优势。挑战包括“根据需要”提供药物的物流以及疾病爆发和药物免疫原性的潜在风险。焦点组包括15名牛皮癣患者(9名女性[60%],平均病程32年[范围9-64年])和9名皮肤科临床医生(8名女性[89%],平均皮肤科经验20年[范围8-33年])。患者和临床医生都认为,“根据需要”的治疗方法将减轻治疗负担,并为患者主导的护理所有权提供机会。两组都强调了确保持续获得药物的重要性,并讨论了牛皮癣复发的潜在影响。患者的偏好受到他们生活经历的影响,特别是以前在药物输送物流和建立疾病控制方面的困难。临床医生的观点是通过患者适应自己的给药时间表的个人经验来了解的。临床医生强调了“根据需要”方法有针对性地选择患者的重要性,持续的疾病监测,并在牛皮癣复发后迅速重新获得药物。
    结论:这些数据表明,银屑病患者和临床医生都可以接受“视需要”的生物治疗。有必要对临床效果和成本效益进行正式评估,使这种方法的现实潜力得以实现。
    BACKGROUND: Biologic therapies have led to increasing numbers of patients with psoriasis who have clear or nearly clear skin. It is current practice to continue biologic therapy indefinitely in these patients, which contributes to a substantial long-term drug and healthcare burden. \'As needed\' biologic therapy in psoriasis may address this; however, our understanding of patient and clinician perceptions of this strategy is limited.
    OBJECTIVE: The aim of this mixed-methods study was to gain insight into the perspectives of both patients and clinicians regarding the acceptability of an \'as needed\' approach to biologic therapy in psoriasis, including potential barriers and enablers to implementation in routine care.
    METHODS: We first conducted UK-wide online scoping surveys of patients with psoriasis and dermatology clinicians to explore their views on \'as needed\' biologic therapy. Using topic guides informed by these survey findings, we then carried out qualitative focus groups with patients and clinicians. Themes were identified using reflexive thematic analysis.
    RESULTS: Of 67 patients and 27 clinicians completing the scoping surveys, 67% (43 of 64 patients) and 78% (21 of 27 clinicians) supported the use of \'as needed\' biologic therapy, respectively. Respondents highlighted advantages such as a reduction in healthcare burden and greater ownership of care. Challenges included logistics of \'as needed\' drug provision and potential risks of disease flare and drug immunogenicity. Focus groups comprised 15 patients with psoriasis [9 female patients (60%), average disease duration 32 years (range 9-64)] and 9 dermatology clinicians [8 female clinicians (89%), average dermatology experience 20 years (range 8-33)]. Both patients and clinicians felt that an \'as needed\' treatment approach will deliver a reduction in treatment burden and present an opportunity for patient-led ownership of care. Both groups highlighted the importance of ensuring ongoing access to medication and discussing the potential impact of psoriasis recurrence. Patient preferences were influenced by their lived experiences, particularly previous difficulties with medication delivery logistics and establishing disease control. Clinician perspectives were informed by personal experience of their patients adapting their own dosing schedules. Clinicians highlighted the importance of targeted patient selection for an \'as needed\' approach, ongoing disease monitoring, and prompt reaccess to medications upon psoriasis recurrence.
    CONCLUSIONS: These data indicate that \'as needed\' biologic therapy in psoriasis is acceptable for both patients and clinicians. Formal assessment of clinical effectiveness and cost-effectiveness is warranted to enable the real-world potential of this approach to be realized.
    Psoriasis is a common skin disease that affects up to 2% of adults in the UK and causes red, scaly patches of skin. A new group of injectable medicines (called biologics) are extremely effective at controlling psoriasis. However, continuous use of these medicines can increase the risk of negative side-effects (such as infections). ‘As needed’ biologic therapy is when a person takes their biologic medication at the first sign of psoriasis recurrence (rather than continuously). This approach has potential to reduce the risks associated with taking biologics, while still maintaining good control of psoriasis symptoms. ‘As needed’ therapy has not been used in psoriasis yet, and so we wanted to know what people with psoriasis and healthcare professionals thought about this approach. We carried out national surveys of people with psoriasis and healthcare professionals to explore their views on ‘as needed’ biologic therapy. We also held group interviews to understand in more detail the positive aspects and potential issues with this approach. Overall, we found that an ‘as needed’ approach was viewed as acceptable by people with psoriasis and healthcare professionals. They thought this approach would reduce the negative impacts of treatment and allow patients to have more ownership of their care. Potential issues included the possibility of patients’ psoriasis returning, as well as ensuring that they had access to medication quickly enough when needed. These findings indicate that ‘as needed’ biologic therapy in psoriasis is acceptable from both a patient and clinician perspective.
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