目的:分析用抗菌剂涂覆基台的有效性及其对涂覆材料的理化和生物学性能的影响。
方法:这项工作已在OpenScienceFramework(osf.io/6tkcp)中注册,并遵循PRISMA协议。在Embase中搜索了截至2021年10月29日发表的文章的两名独立审稿人,PubMed,科学直接,和Scopus数据库。
结果:数据库共发现1,474个参考文献。排除重复项之后,剩下1,050。在阅读标题和摘要并应用纳入标准后,剩下13篇文章,全文阅读。本系统综述共纳入8篇文章。不同的抗菌剂已被用于涂覆基台,包括氧化石墨烯,聚多巴胺,钛和锆氮化物,乳铁蛋白,四环素,银,和多西环素的释放时间不同。钛涂覆的银显示出长达28天的更好的抗微生物剂释放时间。化学分析证实涂覆后表面上存在抗微生物剂。不同的病原微生物,比如血链球菌,口链球菌,和金黄色葡萄球菌,当与涂层表面接触时被抑制。
结论:这篇综述表明,对于哪一种抗微生物剂更好,哪一种涂层材料具有更好的性能仍未达成共识。然而,基台表面涂层与抗菌药物的联合是可行的,可以使许多患者受益,这可以支持他们的临床使用,以促进愈合过程,并防止可能导致牙科植入物治疗失败的感染。
OBJECTIVE: To analyze the effectiveness of coating of abutments with antimicrobial agents and their influence on the physicochemical and biologic properties of the coated materials.
METHODS: This work was registered in Open Science Framework (osf.io/6tkcp) and followed the PRISMA protocols. A search of two independent reviewers of articles published up to October 29, 2021, was performed in the Embase, PubMed, Science Direct, and Scopus databases.
RESULTS: The databases found a total of 1,474 references. After excluding the duplicates, 1,050 remained. After reading the titles and abstracts and applying the inclusion criteria, 13 articles remained and were read in full. A total of 8 articles were included in this systematic
review. Different antimicrobial agents have been used to coat abutments, including graphene oxide, polydopamine, titanium and zirconium nitride, lactoferrin, tetracycline, silver, and doxycycline with varied release times. Titanium-coated silver showed a better antimicrobial agent release time of up to 28 days. Chemical analysis confirmed the presence of antimicrobials on the surface after coating. Different pathogenic microorganisms, such as Streptococcus sanguinis, Streptococcus oralis, and Staphylococcus aureus, were inhibited when in contact with the coated surface.
CONCLUSIONS: This
review showed that there is still no consensus on which is the better antimicrobial agent and which coated materials have the better performance. However, the association of surface coating of abutments with antimicrobials is feasible and can benefit many patients, which can support their clinical use to favor the healing process and prevent infections that can lead to treatment failure with dental implants.