背景2019年冠状病毒病(COVID-19),由严重急性呼吸道综合症冠状病毒2(SARS-CoV-2)引起,不仅对呼吸系统有重大影响,而且对肺外系统也有影响,包括心血管,胃肠,血液学,和免疫反应,尤其是脾脏肿大。COVID-19患者脾脏肿大与肺部并发症之间的联系仍未得到很好的阐明,目前的研究提供了不同的结论。目的本研究旨在阐明脾肿大与脾肿大的相关性。通过计算机断层扫描(CT)成像评估,以及COVID-19患者的肺部受累程度(LI),从而提供对潜在预后指标的见解。方法以医院为基础,横截面,回顾性研究涉及1058例经逆转录聚合酶链反应(RT-PCR)证实的有症状的COVID-19患者,18岁及以上。CT成像用于评估脾脏大小和LI。统计分析,包括皮尔逊相关和简单线性回归,进行研究以探讨脾脏大小与LI之间的关系。结果研究队列显示平均脾脏大小为9.49cm,平均LI评分为0.272。计算出的皮尔逊相关系数为0.0495,表明脾脏大小与LI之间存在边际正相关。回归分析表明脾脏大小对LI的影响最小,脾脏大小仅占LI评分方差的0.2%。结论研究发现,COVID-19患者脾肿大与LI之间的统计学无显着相关性,这表明虽然脾脏肿大可能反映了系统性疾病的参与,并不是肺损伤程度的独立预测因子。研究结果强调了肺外表现的复杂性,并强调需要进一步研究以充分了解脾受累在COVID-19中的意义。
Background Coronavirus disease 2019 (COVID-19), resulting from the severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has not only shown substantial effects on the respiratory system but also on extrapulmonary systems, including cardiovascular, gastrointestinal, hematological, and immune responses, notably spleen enlargement. The connection between the enlargement of the spleen and pulmonary complications in individuals with COVID-19 is still not well elucidated, with current studies offering divergent conclusions. Objective This
study aims to elucidate the correlation between splenomegaly, as assessed by computed tomography (CT) imaging, and the extent of lung involvement (LI) in COVID-19 patients, thereby offering insights into potential prognostic indicators. Methodology A hospital-based, cross-sectional, retrospective
study was conducted involving 1058 symptomatic COVID-19 patients confirmed by reverse transcriptase-polymerase chain reaction (RT-PCR), aged 18 years and above. CT imaging was utilized to evaluate spleen size and LI. Statistical analyses, including Pearson correlation and simple linear regression, were performed to explore the relationship between spleen size and LI. Results The
study cohort exhibited a mean spleen size of 9.49 cm and a mean LI score of 0.272. The Pearson correlation coefficient was calculated at 0.0495, indicating a marginal positive correlation between spleen size and LI. Regression analysis demonstrated a minimal impact of spleen size on LI, with spleen size accounting for only 0.2% of the variance in LI scores. Conclusions The
study found a slight, statistically non-significant correlation between splenomegaly and LI in COVID-19 patients, suggesting that while splenic enlargement may reflect systemic disease involvement, it is not a strong independent predictor of lung damage extent. The findings highlight the complexity of extrapulmonary manifestations and highlight the need for additional research to fully understand the implications of splenic involvement in COVID-19.