背景:Connectome作图可能揭示神经和精神疾病患者的新治疗靶点。然而,具有结构和功能连接体的基于长期延迟召回的网络在很大程度上仍然未知.我们的目标是(1)确定具有结构和功能连接体的基于长期延迟回忆的皮质-海马网络,以及(2)研究其与各种认知功能的关系,年龄,和日常生活活动。
方法:本病例对照研究纳入了131名受试者(73名遗忘型轻度认知障碍[aMCI]患者和58名年龄和教育水平匹配的健康对照[HCs])。所有受试者都完成了神经心理学测试,日常生活活动评估,和多模态磁共振成像。通过概率纤维跟踪和功能连接(FC)分析确定了与长期延迟回忆相关的皮质-海马网络的节点。然后,通过广义线性模型评估了网络对认知功能的主要和交互影响。最后,通过多元回归和Hayes\'bootstrap方法分析了网络对长期延迟回忆与临床特征之间关系的调节作用.在连通性和网络水平上分析了皮层-海马网络的所有影响。
结果:广义线性模型的结果表明,双侧海马,左背外侧额上回,右侧辅助电机区域,左舌回,左侧枕上回,左顶叶上回,左前叶,右颞极(上颞回)是与长期延迟回忆有关的左右皮质-海马网络节点(P<0.05)。在听觉语言学习测试第5部分(AVLT5)得分与左皮质-海马网络的整体特性之间发现了显着的相互作用效应[层次结构,聚类系数,特征路径长度,全球效率,本地效率,西格玛和同步(P<0.05Bonferroni校正)]。在左皮质-海马网络的一般认知功能/执行功能/语言和整体特性之间发现了显着的相互作用效应[Sigma和同步(P<0.05Bonferroni校正)]。
结论:这项研究引入了一种新的基于症状的网络,并描述了认知功能之间的关系,大脑功能,和年龄。受结构和功能连接体约束的皮层-海马网络与长期延迟回忆密切相关。
Connectome mapping may reveal new treatment targets for patients with neurological and psychiatric diseases. However, the long-term delayed recall based-network with structural and functional
connectome is still largely unknown. Our objectives were to (1) identify the long-term delayed recall-based cortex-hippocampus network with structural and functional
connectome and (2) investigate its relationships with various cognitive functions, age, and activities of daily living.
This
case-control study enrolled 131 subjects (73 amnestic mild cognitive impairment [aMCI] patients and 58 age- and education-matched healthy controls [HCs]). All subjects completed a neuropsychological battery, activities of daily living assessment, and multimodal magnetic resonance imaging. Nodes of the cortical-hippocampal network related to long-term delayed recall were identified by probabilistic fiber tracking and functional connectivity (FC) analysis. Then, the main and interaction effects of the network on cognitive functions were assessed by a generalized linear model. Finally, the moderating effects of the network on the relationships between long-term delayed recall and clinical features were analyzed by multiple regression and Hayes\' bootstrap method. All the effects of cortex-hippocampus network were analyzed at the connectivity and network levels.
The result of a generalized linear model showed that the bilateral hippocampus, left dorsolateral superior frontal gyrus, right supplementary motor area, left lingual gyrus, left superior occipital gyrus, left superior parietal gyrus, left precuneus, and right temporal pole (superior temporal gyrus) are the left and right cortex-hippocampus network nodes related to long-term delayed recall (P < 0.05). Significant interaction effects were found between the Auditory Verbal Learning Test Part 5 (AVLT 5) scores and global properties of the left cortex-hippocampus network [hierarchy, clustering coefficient, characteristic path length, global efficiency, local efficiency, Sigma and synchronization (P < 0.05 Bonferroni corrected)]. Significant interaction effects were found between the general cognitive function/executive function/language and global properties of the left cortex-hippocampus network [Sigma and synchronization (P < 0.05 Bonferroni corrected)].
This study introduces a novel symptom-based network and describes relationships among cognitive functions, brain function, and age. The cortex-hippocampus network constrained by the structural and functional
connectome is closely related to long-term delayed recall.