皮质扩散抑制(CSD)是脑组织明显去极化的波,伴随着离子浓度和细胞肿胀的实质性变化。这里,我们验证了电势建模的计算框架,离子运动,CSD期间脑组织细胞肿胀。我们考虑代表野生型(WT)或敲除/敲除小鼠的不同模型变化,并将数值结果与一系列实验研究的报告进行系统比较。我们发现几个CSD标志的数据是通过计算获得的,包括波的传播速度,直流换档持续时间,细胞外K浓度的峰值以及细胞外空间(ECS)的明显收缩与先前通过实验观察到的结果完全一致。Further,我们评估关键模型参数,包括细胞扩散率,结构比率,膜水和/或K+渗透率影响CSD特性集。
Cortical spreading depression (CSD) is a wave of pronounced depolarization of brain tissue accompanied by substantial shifts in ionic concentrations and cellular swelling. Here, we validate a computational framework for modeling electrical potentials, ionic movement, and cellular swelling in brain tissue during CSD. We consider different model variations representing wild-type (WT) or knock-out/knock-down mice and systematically compare the numerical results with
reports from a selection of experimental studies. We find that the data for several CSD hallmarks obtained computationally, including wave propagation speed, direct current shift duration, peak in extracellular K+ concentration as well as a pronounced shrinkage of extracellular space (ECS) are well in line with what has previously been observed experimentally. Further, we assess how key model parameters including cellular diffusivity, structural ratios, membrane water and/or K+ permeabilities affect the set of CSD characteristics.