背景:疲劳是在各种慢性疾病中发现的一种使人衰弱的症状,并且与更严重的症状和更差的生活质量(QoL)有关。然而,这种症状在慢性胰腺炎(CP)中没有得到充分解决,并且没有关于CP患者疲劳的研究。
方法:这项横断面研究在上海长海医院进行,中国。关于患者社会人口统计学的数据,疾病,并收集治疗特征。使用多维疲劳清单-20评估疲劳。使用欧洲癌症研究与治疗组织QoL问卷(EORTC-QLQ-C30)评估QoL。睡眠质量,焦虑和抑郁,使用匹兹堡睡眠质量指数评估疼痛,医院焦虑和抑郁量表,和简短的疼痛清单,分别。
结果:中国CP患者的疲劳患病率为35.51%(87/245)。多因素分析显示脂肪泻(OR=2.638,95%CI:1.117-6.234),吸烟史(OR=4.627,95%CI:1.202-17.802),内镜治疗史(OR=0.419,95%CI:0.185-0.950),抑郁症(OR=5.924,95%CI:2.462-14.255),睡眠障碍(OR=6.184,95%CI:2.543~15.034)是疲劳存在的影响因素。EORTC-QLQ-C30中的全球健康和所有功能维度得分显着下降,而疲劳患者的所有症状维度的得分均显着增加。
结论:这项研究表明,疲劳是一种常见的症状,对CP患者的QoL有负面影响。脂肪肝,吸烟史,内镜治疗,抑郁症,睡眠障碍与疲劳有关。
BACKGROUND: Fatigue is a debilitating symptom found in various chronic diseases and is associated with more severe symptoms and worse quality of life (QoL). However, this symptom has not been adequately addressed in chronic pancreatitis (CP), and there have been no studies on fatigue in patients with CP.
METHODS: This cross-sectional
study was conducted at the Changhai Hospital in Shanghai, China. Data on the patients\' sociodemographic, disease, and therapeutic characteristics were collected. Fatigue was assessed using the Multidimensional Fatigue Inventory-20. QoL was assessed utilizing the European Organization for the Research and Treatment of Cancer of QoL questionnaire (EORTC-QLQ-C30). Sleep quality, anxiety and depression, and pain was assessed using Pittsburgh Sleep Quality Index, the Hospital Anxiety and Depression Scale, and the Brief Pain Inventory, respectively.
RESULTS: The prevalence of fatigue among Chinese patients with CP was 35.51 % (87/245). Multivariate analysis showed that steatorrhea (OR = 2.638, 95 % CI: 1.117-6.234), history of smoking (OR = 4.627, 95 % CI: 1.202-17.802), history of endoscopic treatment (OR = 0.419, 95 % CI: 0.185-0.950), depression (OR = 5.924, 95 % CI: 2.462-14.255), and sleep disorder (OR = 6.184, 95 % CI: 2.543-15.034) were influencing factors for the presence of fatigue. The scores for global health and all functional dimensions in the EORTC-QLQ-C30 significantly decreased, whereas the scores for all symptom dimensions significantly increased in patients with fatigue.
CONCLUSIONS: This
study indicated that Fatigue is a common symptom and has a negative impact on the QoL of patients with CP. Steatorrhea, smoking history, endoscopic treatment, depression, and sleep disorders were associated with fatigue.