纳米粒子(NPs),一种独特的颗粒,尺寸范围从1到100纳米,是21世纪最有前途的技术之一,和二氧化钛NP(TiO2NP)是全球生产和使用最广泛的NP之一。TiO2NP应用的增加引起了人们对其全球安全性和暴露风险的担忧。许多动物研究报道了TiO2NPs在女性生殖器官中的积累;然而,由此产生的毒性的证据仍然模棱两可。由于NPs的表面积和化学修饰可以显著改变其细胞毒性,我们旨在比较原始TiO2粉末与表面改性的TiO2粉末与水杨酸(TiO2/SA)和5-氨基水杨酸(TiO2/5-ASA)对卵巢的毒性作用,输卵管,急性口服治疗后第14天和子宫。结果,基于食物和水摄入量的变化,体重,器官与身体质量比,荷尔蒙状态,感兴趣组织的组织学特征,和抗氧化剂参数,建议用5-ASA改性可以减轻一些观察到的TiO2粉末的毒性作用,并鼓励未来的研究,以创建可以潜在地减少TiO2NP的有害影响,同时保持其积极影响。
Nanoparticles (NPs), a distinct class of particles ranging in size from 1 to 100 nm, are one of the most promising technologies of the 21st century, and titanium dioxide NPs (TiO2 NPs) are among the most widely produced and used NPs globally. The increased application of TiO2 NPs raises concerns regarding their global safety and risks of exposure. Many animal studies have reported the accumulation of TiO2 NPs in female reproductive organs; however, evidence of the resultant toxicity remains ambiguous. Since the surface area and chemical modifications of NPs can significantly change their cytotoxicity, we aimed to compare the toxic effects of pristine TiO2 powder with surface-modified TiO2 powders with salicylic acid (TiO2/SA) and 5-aminosalicylic acid (TiO2/5-ASA) on the ovaries, oviducts, and uterus on the 14th day following acute oral treatment. The results, based on alterations in food and water intake, body mass, organ-to-body mass ratio, hormonal status, histological features of tissues of interest, and antioxidant parameters, suggest that the modification with 5-ASA can mitigate some of the observed toxic effects of TiO2 powder and encourage future investigations to create NPs that can potentially reduce the harmful effects of TiO2 NPs while preserving their positive impacts.