代谢综合征表现出与各种神经系统疾病的关联,其对大脑皮层的潜在影响可能是导致这些不良后果的众多潜在因素之一。在这项研究中,本研究采用孟德尔随机化分析,探讨代谢综合征与大脑皮层结构变化之间的因果关系.代谢综合征5种成分的全基因组关联研究数据来自英国生物库的欧洲血统个体。34个已知皮质功能区的全基因组关联研究数据来自ENIGMA联盟。关于阿尔茨海默病的数据,严重的抑郁症,和焦虑症从IEU开放全基因组关联研究数据库获得。代谢综合征要素与大脑皮层结构之间的因果关系使用方差逆加权进行评估,孟德尔随机化-Egger,和加权中位数技术,以方差倒数加权为主要方法。反向方差加权,孟德尔随机化Egger,加权中位数,简单模式,和加权模式方法被用来评估代谢综合征和神经系统疾病(阿尔茨海默病,严重的抑郁症,和焦虑症)。异常值,异质性,使用CochranQ检验评估多效性,MR-PRESSO,遗漏分析,和漏斗图。全球范围内,未发现代谢综合征与总皮质厚度或表面积之间存在因果关系.然而,区域性,代谢综合征可能会影响特定区域的表面积,包括尾前扣带回,postcentral,后扣带回,前扣带,峡部扣带回,上顶叶,前额叶中部,中颞叶,脑岛,parsopercularis,Cuneus,和下颞叶。它也可能影响内侧眶额的厚度,尾部中部额叶,paracentral,上额叶,上顶叶,和上边缘区域。这些发现名义上是显著的,经受住了敏感性分析,没有实质性的异质性或多效性。此外,我们发现代谢综合征与阿尔茨海默病的风险之间存在关联,严重的抑郁症,和焦虑症。这项研究表明,代谢综合征与大脑皮层结构变化之间存在潜在的关联,这可能是某些神经系统疾病的基础。此外,我们发现代谢综合征与阿尔茨海默病的风险之间存在关联,严重的抑郁症,和焦虑症。代谢综合征的早期诊断对于预防这些神经系统疾病具有重要意义。
Metabolic syndrome exhibits associations with diverse neurological disorders, and its potential influence on the cerebral cortex may be one of the many potential factors contributing to these adverse outcomes. In this
study, we aimed to investigate the causal relationship between metabolic syndrome and changes in cerebral cortex structure using Mendelian randomization analysis. Genome-wide association
study data for the 5 components of metabolic syndrome were obtained from individuals of European descent in the UK Biobank. Genome-wide association
study data for 34 known cortical functional regions were sourced from the ENIGMA Consortium. Data on Alzheimer\'s disease, major depression, and anxiety disorder were obtained from the IEU Open genome-wide association
study database. The causal links between metabolic syndrome elements and cerebral cortex architecture were evaluated using inverse variance weighting, Mendelian randomization-Egger, and weighted median techniques, with inverse variance weighting as the primary method. Inverse variance weighting, Mendelian randomization Egger, weighted median, simple mode, and weighted mode methods were employed to assess the relationships between metabolic syndrome and neurological diseases (Alzheimer\'s disease, major depression, and anxiety disorder). Outliers, heterogeneity, and pleiotropy were assessed using Cochran\'s Q test, MR-PRESSO, leave-one-out analysis, and funnel plots. Globally, no causal link was found between metabolic syndrome and overall cortical thickness or surface area. However, regionally, metabolic syndrome may influence the surface area of specific regions, including the caudal anterior cingulate, postcentral, posterior cingulate, rostral anterior cingulate, isthmus cingulate, superior parietal, rostral middle frontal, middle temporal, insula, pars opercularis, cuneus, and inferior temporal. It may also affect the thickness of the medial orbitofrontal, caudal middle frontal, paracentral, superior frontal, superior parietal, and supramarginal regions. These findings were nominally significant and withstood sensitivity analyses, showing no substantial heterogeneity or pleiotropy. Furthermore, we found an association between metabolic syndrome and the risk of Alzheimer\'s disease, major depression, and anxiety disorder. This
study suggests a potential association between metabolic syndrome and changes in cerebral cortex structure, which may underlie certain neurological disorders. Furthermore, we found an association between metabolic syndrome and the risk of Alzheimer\'s disease, major depression, and anxiety disorder. Early diagnosis of metabolic syndrome holds significance in preventing these neurological disorders.