背景:子宫内膜异位症和卵巢癌之间可能的病因学关联已在文献中反复报道。
目的:我们的目的是评估有关此问题的已发表的流行病学数据。
方法:我们对MEDLINE中的文献进行了广泛的搜索,在2014年2月之前发表的文章中,使用关键词“子宫内膜异位症”和“卵巢”以及标题中的以下术语之一:“癌症”或“恶性肿瘤”或“恶性肿瘤”或“肿瘤”或“肿瘤”或“肿瘤”。“检索的论文被检查进一步的相关出版物。
结果:总体而言,我们的搜索产生了1项前瞻性队列研究,10个回顾性队列,5项病例对照研究。对这些研究进行荟萃分析被认为是不合适的,由于数据报告的差异,研究设计,以及对混杂因素的调整。
结论:研究发现的主要局限性,除了一个例外,是缺乏子宫内膜异位症的手术确认。
结论:在大多数研究中,子宫内膜异位症与透明细胞和子宫内膜样卵巢癌的相关性是一致的。另一方面,现有的将子宫内膜异位症与卵巢癌联系起来的流行病学证据不足以改变目前的临床实践.前瞻性队列研究,与先前的腹腔镜确认,本地化,需要对子宫内膜异位症进行分期,为了进一步澄清这个问题。
BACKGROUND: A possible etiological association between endometriosis and ovarian cancer has been repeatedly reported in the literature.
OBJECTIVE: Our aim was to evaluate published epidemiological data on this issue.
METHODS: We conducted an extensive search of the literature in MEDLINE, of articles ever published until February 2014, using the key-words \"endometriosis\" and \"ovarian\" and one of the following terms in the title: \"cancer\" or \"malignancy\" or \"malignant\" or \"tumor\" or \"neoplasia\" or \"neoplasm\" or \"transformation.\" Retrieved papers were checked for further relevant publications.
RESULTS: Overall, our search yielded 1 prospective cohort study, 10 retrospective cohort, and 5 case-control studies. A meta-analysis of these studies was not considered to be appropriate, due to differences in data reporting, study design, and adjustment for confounding factors.
CONCLUSIONS: The main limitation of studies found, with one exception, was the lack of operative confirmation of endometriosis.
CONCLUSIONS: An association of endometriosis with clear-cell and endometrioid ovarian cancer was a consistent finding in most studies. On the other hand, existing epidemiological evidence linking endometriosis with ovarian cancer is insufficient to change current clinical practice. Prospective cohort studies, with prior laparoscopic confirmation, localization, and staging of endometriosis are needed, in order to further clarify this issue.