■进行了一项荟萃分析,以检查抑郁症患者和健康个体之间的心率变异性(HRV)的差异,目的为抑郁症的诊断和心血管疾病的预防提供理论依据。
■搜索中国国家知识基础设施(CNKI),万方,VIP,PubMed,WebofScience,科学直接,和Cochrane图书馆数据库收集抑郁症患者HRV的病例对照研究,检索日期是从数据库建立到2022年12月。采用有效公共卫生实践项目(EPHPP)量表评价文献质量,采用Stata14.0软件进行Meta分析。
■这项研究由43篇论文组成,22个中文,21个英文,其中包括抑郁症组的2359名受试者和健康对照组的3547名受试者。Meta分析结果显示,与健康对照组相比,抑郁症患者的SDNN较低[对冲=-0.87,95%CI(-1.14,-0.60),Z=-6.254,p<0.01],RMSSD[对冲=-0.51,95%CI(-0.69,-0.33),Z=-5.525,p<0.01],PNN50[对冲=-0.43,95%CI(-0.59,-0.27),Z=-5.245,p<0.01],LF[对冲=-0.34,95%CI(-0.55,-0.13),Z=-3.104,p<0.01],和HF[对冲=-0.51,95%CI(-0.69,-0.33),Z=-5.669p<0.01],和LF/HF[对冲=-0.05,95%CI(-0.27,0.18),Z=-0.410,p=0.682]差异无统计学意义。
■这项研究表明,抑郁症患者的HRV指标低于健康人群,除了LF/HF,这表明抑郁症患者可能比健康人群更容易患心血管疾病。
A meta-analysis was conducted to examine the differences in heart rate variability (HRV) between depressed patients and healthy individuals, with the purpose of providing a theoretical basis for the diagnosis of depression and the prevention of cardiovascular diseases.
To search China National Knowledge Infrastructure (CNKI), WanFang, VIP, PubMed, Web of Science, Science Direct, and Cochrane Library databases to collect case-control studies on HRV in depressed patients, the retrieval date is from the establishment of the database to December 2022. Effective Public Health Practice Project (EPHPP) scale was used to evaluate literature quality, and Stata14.0 software was used for meta-analysis.
This study comprised of 43 papers, 22 written in Chinese and 21 in English, that included 2,359 subjects in the depression group and 3,547 in the healthy control group. Meta-analysis results showed that compared with the healthy control group, patients with depression had lower SDNN [Hedges\' g = -0.87, 95% CI (-1.14, -0.60), Z = -6.254, p < 0.01], RMSSD [Hedges\' g = -0.51, 95% CI (-0.69,-0.33), Z = -5.525, p < 0.01], PNN50 [Hedges\' g = -0.43, 95% CI (-0.59, -0.27), Z = -5.245, p < 0.01], LF [Hedges\' g = -0.34, 95% CI (-0.55, - 0.13), Z = -3.104, p < 0.01], and HF [Hedges\' g = -0.51, 95% CI (-0.69, -0.33), Z = -5.669 p < 0.01], and LF/HF [Hedges\' g = -0.05, 95% CI (-0.27, 0.18), Z = -0.410, p = 0.682] showed no significant difference.
This research revealed that HRV measures of depressed individuals were lower than those of the healthy population, except for LF/HF, suggesting that people with depression may be more at risk of cardiovascular diseases than the healthy population.