Supercenarians,年龄达到110岁的人,代表了人类长寿的终极模式。我们从生物医学和心理社会的角度进行了研究,以阐明有助于健康长寿的因素。目前的研究描述了世界上最古老的活人的临床过程。
KimuraJiroemon,他是历史上被证实的最年长的人,活了116年以上。我们进行了一项纵向调查,包括身体和心理评估,血液数据,和从111岁开始的心电图(ECG),并在他生命的最后一年住院期间获得了医学数据,例如计算机断层扫描(CT)图像。
在111岁时,Jiroemon几乎独立于日常生活活动。此外,他的费城老年中心士气量表得分为15/17,表明心理健康较高。他的生物学数据包括心电图上的一级房室(AV)传导阻滞;血红蛋白轻度下降(11.6g/dL),血细胞比容(36.2%),和白蛋白水平(3.5g/dL);和血清胱抑素C水平升高(1.32mg/L),表明肾脏和电传导系统的潜在功能障碍。然后,他一直没有致命的疾病,直到115岁。在这个年龄,他失去了知觉,他的心电图显示完全房室传导阻滞。在第一次住院接受强化检查时,他的医生建议植入心脏起搏器,但他和他的家人拒绝了.2012年12月12日,他的病情迅速恶化,他因房室传导阻滞导致心力衰竭两次住院。2013年5月11日,他在早餐后失去了知觉,他第四次住院了.根据他的胸部CT发现和脑钠肽水平升高(160pg/mL),他被诊断为肺炎和心力衰竭,于2013年6月12日去世,享年116岁。
尽管他一生中没有心血管危险因素,Jiroemon因潜在的心脏和肾脏功能障碍而导致心力衰竭,这表明心肾系统的衰老是世界上最年长的人的最终病理。他的临床课程代表了抑制发病率和极端寿命的模型。需要从生理和心理方面进行全面的健康和长寿研究。
Supercentenarians, people who have reached 110 years of age, represent an ultimate model of human longevity. We have conducted research from both biomedical and psychosocial perspectives to clarify the factors that contribute to healthy longevity. The current study described the clinical course of the oldest lived man in the world.
Kimura Jiroemon, who is the verified oldest man in recorded history, lived for more than 116 years. We conducted a longitudinal investigation including physical and psychological assessments, blood data, and electrocardiogram (ECG) from the age of 111 and obtained medical data such as computed tomography (CT) images during the course of hospitalizations in the last year of his life.
At the age of 111, Jiroemon was almost independent regarding activities of daily living. Additionally, his Philadelphia Geriatric Center Morale Scale score was 15/17, indicating high psychological well-being. His biological data included first-degree atrioventricular (AV) block on ECG; mild decreases of hemoglobin (11.6 g/dL), hematocrit (36.2%), and albumin levels (3.5 g/dL); and elevated serum cystatin C levels (1.32 mg/L), indicating potential dysfunction of the renal and electrical conduction systems. He then lived without fatal illness until the age of 115 years. At this age, he lost consciousness, and his ECG revealed complete AV block. At the first hospitalization for intensive examination, his doctor recommended implanting a cardiac pacemaker, but he and his family declined. On December 12, 2012, his condition rapidly worsened, and he was hospitalized twice for heart failure because of AV block. On May 11, 2013, he lost consciousness after breakfast, and he was hospitalized for the fourth time. He was diagnosed with pneumonia and heart failure based on his chest CT findings and elevated brain natriuretic peptide levels (160 pg/mL), and died on June 12, 2013 at the age of 116.
Despite having no cardiovascular risk factors throughout his life, Jiroemon developed heart failure from potential heart and kidney dysfunction, suggesting that aging of the cardiorenal system was the ultimate pathology of the oldest man in the world. His clinical course represents a model of both suppression of morbidity and extreme longevity. Comprehensive health and longevity research studies from physical and psychological aspects are required.