PDF(Pubmed)
Abstract：
Congestive nephropathy is an underappreciated manifestation of cardiorenal syndrome and is characterized by a potentially reversible kidney dysfunction caused by a reduced renal venous outflow secondary to right-sided heart failure or intra-abdominal hypertension. To date, the histological diagnostic criteria for congestive nephropathy have not been defined. We herein report a case of acute renal dysfunction following cardiac allograft failure and present a review of the relevant literature to elucidate the current understanding of the disease. Our case demonstrated that congestion-driven nephropathy may be histopathologically characterized by markedly dilated veins and peritubular capillaries, focally accentuated low-grade acute tubular damage, small areas of interstitial fibrosis, and tubular atrophy on a background of normal glomeruli and predominantly normal tubular cell differentiation.
摘要：
充血性肾病是心肾综合征的一种未被重视的表现，其特征是由右侧心力衰竭或腹内高压继发的肾静脉流出减少引起的潜在可逆性肾功能障碍。迄今为止,充血性肾病的组织学诊断标准尚未确定.我们在此报告一例同种异体心脏移植失败后急性肾功能不全，并对相关文献进行综述，以阐明当前对该疾病的理解。我们的病例表明，充血性肾病的组织病理学特征可能是静脉和肾小管周围毛细血管明显扩张，局灶性加重的低度急性肾小管损伤，间质纤维化的小区域，和正常肾小球和主要正常肾小管细胞分化背景下的肾小管萎缩。
