cannabinoid receptors

大麻素受体
  • 文章类型: Case Reports
    大麻呕吐综合征(CHS)是一种以慢性大麻使用者的周期性呕吐和腹痛为特征的疾病。它是由长期使用大麻引起的,经常被误诊或未被识别。CHS会导致脱水,电解质失衡,肾功能衰竭,加剧肾结石或肾结石的风险。肾结石是一种常见的泌尿系统疾病,其特征是在肾脏中形成固体结石,输尿管,或膀胱。CHS与肾结石之间的关联尚不清楚,需要进一步研究。然而,提示CHS可能由于脱水和电解质失衡而增加肾结石的风险。因此,医疗保健专业人员应该意识到CHS的潜在并发症,并监测患者的肾结石,尤其是慢性大麻使用者。我们报告了一个28岁的美国印度男性,有每日使用大麻的历史,出现复发性肾结石和急性绞痛。
    Cannabis hyperemesis syndrome (CHS) is a condition characterized by cyclic vomiting and abdominal pain in chronic cannabis users. It is caused by long-term cannabis use and is often misdiagnosed or unrecognized. CHS can lead to dehydration, electrolyte imbalances, and renal failure, exacerbating the risk of nephrolithiasis or kidney stones. Nephrolithiasis is a common urologic condition characterized by the formation of solid stones in the kidneys, ureters, or bladder. The association between CHS and nephrolithiasis is still unclear and requires further investigation. However, it is suggested that CHS may increase the risk of nephrolithiasis due to dehydration and electrolyte imbalances. Therefore, healthcare professionals should be aware of the potential complications of CHS and monitor patients for kidney stones, especially in chronic cannabis users. We report a case of a 28-year-old American-Indian male with a history of daily marijuana use, presented with recurrent renal stones and acute colicky pain.
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    文章类型: Journal Article
    大麻的使用及其合法化一直在快速增长,被广泛的年龄组虐待。它对心脏的影响是众所周知的,但是仅大麻引起的ST段抬高型心肌梗死(STEMI)的冠状动脉血管痉挛鲜为人知。在这里,我们报道了一例有显著烟草吸烟史的中年非裔美国男子,他在吸食大麻后不久出现典型的心肌梗死(MI)胸痛.心电图显示下导联ST升高,一级房室传导阻滞,尿液药物筛查仅对大麻呈阳性。冠状动脉造影显示右冠状动脉(RCA)中段阻塞,经冠状动脉内注射硝酸甘油后缓解。该病例报告恢复了在初次就诊时将药物滥用视为STEMI病因的重要性。排除尿液药物样本。我们还提供了STEMI冠状动脉血管痉挛的文献综述,特别由大麻及其病理生理机制诱导。
    The usage of marijuana and its legalization has been growing rapidly, being abused by a wide range of age groups. Its effects on the heart are well known, but coronary artery vasospasm causing ST elevation myocardial infarction (STEMI) from Marijuana alone is rather lesser known. Herein, we report a case of a middle aged African American man with a significant tobacco smoking history who presented with chest pain typical of myocardial infarction (MI) soon after smoking marijuana. ECG showed ST elevation in inferior leads with first degree AV block and a urine drug screen positive only for marijuana. Coronary angiogram showed mid right coronary artery (RCA) obstruction which was relieved upon injection of intracoronary nitroglycerine. This case report reinstates the significance of considering substance abuse as an etiology of STEMI during initial presentation, ruling out with urine drug samples. We also present a literature review of coronary vasospasm with STEMI, induced specifically by Marijuana and its pathophysiologic mechanisms.
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