■目前缺乏关于针灸治疗实验性脑出血（ICH）的循证医学证据。这项研究的目的是根据神经功能评分和脑含水量（BWC）系统地评估针刺治疗实验性ICH的疗效。
■检索了八个主流的中英文数据库。结果指标包括神经功能评分和BWC，根据研究特点进行亚组分析。
■共纳入32项研究。Meta分析结果表明,与对照组相比,针刺组显着降低mNSS（MD=-3.16，p<0.00001），Bederson评分（MD=-0.99，p<0.00001），隆加评分（MD=-0.54，p<0.0001），和脑含水量（MD=-5.39，p<0.00001）。亚组分析显示，对于mNSS，自体血液模型（MD=-3.36）比胶原酶模型（MD=-0.92，p<0.00001）产生更好的结果，单纯固定（MD=-3.38）或不固定（MD=-3.39）优于假针刺（MD=-0.92，p<0.00001）。对于BWC，自体血液模型（MD=-7.73）优于胶原酶模型（MD=-2.76，p<0.00001），和GV20-GB7(MD=-7.27)比其他穴位(MD=-2.92,p=0.0006)更有效。
■针刺可显著改善实验性ICH的神经功能缺损和脑水肿。GV20-GB7的针刺比其他点更有效。这些发现支持将针灸转化为人类ICH临床治疗的进一步研究。
■https://www.crd.约克。AC.英国/普华永道/，标识符CRD42023435584。
UNASSIGNED: There is currently a lack of evidence in evidence-based medicine regarding acupuncture treatment for experimental intracerebral hemorrhage (ICH). The aim of this study was to systematically evaluate the efficacy of acupuncture treatment for experimental ICH based on neurological function scores and brain water content (BWC).
UNASSIGNED: Eight mainstream Chinese and English databases were searched. Outcome measures included neurological function scores and BWC, and subgroup analysis was conducted based on study characteristics.
UNASSIGNED: A total of 32 studies were included. Meta-analysis results indicated that compared to the control group, the acupuncture group showed significant reductions in mNSS (MD = -3.16, p < 0.00001), Bederson score (MD = -0.99, p < 0.00001), Longa score (MD = -0.54, p < 0.0001), and brain water content (MD = -5.39, p < 0.00001). Subgroup analysis revealed that for mNSS, the autologous blood model (MD = -3.36) yielded better results than the collagenase model (MD = -0.92, p < 0.00001), and simple fixation (MD = -3.38) or no fixation (MD = -3.39) was superior to sham acupuncture (MD = -0.92, p < 0.00001). For BWC, the autologous blood model (MD = -7.73) outperformed the collagenase model (MD = -2.76, p < 0.00001), and GV20-GB7 (MD = -7.27) was more effective than other acupuncture points (MD = -2.92, p = 0.0006).
UNASSIGNED: Acupuncture significantly improves neurological deficits and brain edema in experimental ICH. Acupuncture at GV20 - GB7 is more effective than at other points. These findings support further studies to translate acupuncture into clinical treatment for human ICH.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42023435584.
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