UNASSIGNED: Eight mainstream Chinese and English databases were searched. Outcome measures included neurological function scores and BWC, and subgroup analysis was conducted based on study characteristics.
UNASSIGNED: A total of 32 studies were included. Meta-analysis results indicated that compared to the control group, the acupuncture group showed significant reductions in mNSS (MD = -3.16, p < 0.00001), Bederson score (MD = -0.99, p < 0.00001), Longa score (MD = -0.54, p < 0.0001), and brain water content (MD = -5.39, p < 0.00001). Subgroup analysis revealed that for mNSS, the autologous blood model (MD = -3.36) yielded better results than the collagenase model (MD = -0.92, p < 0.00001), and simple fixation (MD = -3.38) or no fixation (MD = -3.39) was superior to sham acupuncture (MD = -0.92, p < 0.00001). For BWC, the autologous blood model (MD = -7.73) outperformed the collagenase model (MD = -2.76, p < 0.00001), and GV20-GB7 (MD = -7.27) was more effective than other acupuncture points (MD = -2.92, p = 0.0006).
UNASSIGNED: Acupuncture significantly improves neurological deficits and brain edema in experimental ICH. Acupuncture at GV20 - GB7 is more effective than at other points. These findings support further studies to translate acupuncture into clinical treatment for human ICH.
UNASSIGNED: https://www.crd.york.ac.uk/prospero/, identifier CRD42023435584.
■检索了八个主流的中英文数据库。结果指标包括神经功能评分和BWC,根据研究特点进行亚组分析。
■共纳入32项研究。Meta分析结果表明,与对照组相比,针刺组显着降低mNSS(MD=-3.16,p<0.00001),Bederson评分(MD=-0.99,p<0.00001),隆加评分(MD=-0.54,p<0.0001),和脑含水量(MD=-5.39,p<0.00001)。亚组分析显示,对于mNSS,自体血液模型(MD=-3.36)比胶原酶模型(MD=-0.92,p<0.00001)产生更好的结果,单纯固定(MD=-3.38)或不固定(MD=-3.39)优于假针刺(MD=-0.92,p<0.00001)。对于BWC,自体血液模型(MD=-7.73)优于胶原酶模型(MD=-2.76,p<0.00001),和GV20-GB7(MD=-7.27)比其他穴位(MD=-2.92,p=0.0006)更有效。
■针刺可显著改善实验性ICH的神经功能缺损和脑水肿。GV20-GB7的针刺比其他点更有效。这些发现支持将针灸转化为人类ICH临床治疗的进一步研究。
■https://www.crd.约克。AC.英国/普华永道/,标识符CRD42023435584。