已经发现外部和内部压力源不利地影响皮肤健康和整体健康。人们对使用抗炎和抗氧化植物来源的成分越来越感兴趣,比如ashwagandha,藏红花,l-茶氨酸,和生育酚,减轻这些压力的影响。在这项研究中,我们评估口服和外用产品(InnerCalm和SuperCalm,分别)含有皮肤发红的天然成分,皮肤色素沉着,睡眠,与Fitzpatrick皮肤类型1-4和自我感知敏感皮肤的健康女性的情绪。受试者随机分为口服(口服组),局部(局部组),或口服和局部干预的组合(联合组)。使用基于标准化摄影的图像分析来评估皮肤发红和色素。情绪和睡眠的自我评估是通过简短的情绪状态(POMS)问卷进行测量的,和匹兹堡睡眠质量指数(PSQI),分别。在基线时进行评估,1周,4周,和8周的干预。局部组在8周时平均面部发红下降(p<0.001),联合组在4周(p<0.05)和8周(p<0.001),相对于基线。在8周时,口腔(p&lt;0.05)和合并(p&lt;0.05)队列中的平均面部色素沉着减少,相对于基线。口服组在1周时相对于基线(p<0.05)和在8周时相对于基线(p<0.05)表现出睡眠质量的改善。最后,联合治疗组在8周时相对于基线表现出疲劳(p<0.01)和意识模糊(p<0.05)的改善,尽管在研究过程中,所有3组的总情绪障碍都有所增加。与情绪相关的测量结果可能与研究的时机相混淆,在COVID大流行期间运行。总的来说,我们展示了口服和局部草药以及营养保健品对皮肤健康和保健的作用。需要进一步的研究来阐明口服和局部组合方案中的协同作用。
External and internal stressors have been found to adversely affect skin health and overall wellness. There is growing interest in the use of anti-inflammatory and antioxidant plant-derived ingredients, such as ashwagandha, saffron, l-theanine, and tocopherol, to mitigate the impact of these stressors. In this
study, we evaluate the effectiveness of oral and topical products (InnerCalm and SuperCalm, respectively) that contain naturally derived ingredients on skin redness, skin pigmentation, sleep, and mood in healthy females with Fitzpatrick skin type 1−4 and self-perceived sensitive skin. Subjects were randomized to an oral (oral group), a topical (topical group), or a combination of both the oral and topical interventions (combined group). Standardized photography-based image analysis was used to assess skin redness and pigment. Self-assessments of mood and sleep were measured with the abbreviated profile of mood states (POMS) questionnaire, and the Pittsburgh sleep-quality index (PSQI), respectively. Assessments were made at the baseline, 1-week, 4-weeks, and 8-weeks of the intervention. The average facial redness decreased in the topical group at 8-weeks (p < 0.001) and in the combined group at 4-weeks (p < 0.05) and 8-weeks (p < 0.001), relative to the baseline. The average facial pigmentation decreased in the oral (p < 0.05) and combined (p < 0.05) cohorts at 8-weeks, relative to the baseline. The oral group exhibited an improvement in sleep quality at 1-week relative to the baseline (p < 0.05) and at 8-weeks relative to the baseline (p < 0.05). Finally, the combined group demonstrated improvement in fatigue (p < 0.01) and confusion (p < 0.05) at 8-weeks relative to the baseline, though total mood disturbance increased in all 3 groups over the course of the
study. Measured outcomes relating to mood may be confounded with the timing of the
study, which ran during the COVID pandemic. Overall, we demonstrate the role of oral and topical herbs and of nutraceuticals for skin health and wellness. Further research will be needed to elucidate synergistic effects in oral and topical combination regimens.