在成骨和骨建模过程中,已检测到高血管和成骨细胞/破骨细胞活性。这种活性的降低是完全骨形成和成熟的标志。牙槽骨成熟似乎在几周和几个月内发生;然而,牙槽骨建模的精确时间仍然未知.这项临床初步研究的目的是研究正畸挤压运动过程中新贴壁组织的骨建模,通过对人体活检的组织形态分析。这项研究是在下颌第三磨牙窝进行的,2010年至2014年间,所有牙齿均在正畸挤压后拔除。经过不同的稳定时间,进行了提取,并从每个牙槽中采集新沉积的骨标本进行组织形态计量学分析。评估组织学参数以鉴定骨的数量和质量。这项研究包括从9名患者中提取的12颗牙齿。所有标本均由骨组织组成。稳定1个月和1.5个月后采集的骨样本显示出显著百分比的编织骨,而两个月后,观察到相关下降。组织形态计量学分析表明,正畸挤压后,2个月的稳定期可以使新生骨成熟。
During osteogenesis and bone modeling, high vascularity and osteoblastic/osteoclastic cell activity have been detected. A decrease in this activity is a sign of complete bone formation and maturation. Alveolar bone maturation seems to occur within weeks and months; however, the precise timing of the alveolar bone modeling is still unknown. The aim of this clinical pilot
study was to investigate the bone modeling of neo-apposed tissue during orthodontic extrusive movements, through a histomorphometric analysis of human biopsies. This
study was conducted on third mandibular molars sockets, and all teeth were extracted after orthodontic extrusion between 2010 and 2014. After different stabilization timings, extractions were performed, and a specimen of neo-deposed bone was harvested from each socket for the histomorphometric analysis. Histological parameters were evaluated to identify bone quantity and quality. This
study included 12 teeth extracted from 9 patients. All specimens were composed of bone tissue. Bone samples taken after 1 and 1.5 months of stabilization presented remarkable percentages of woven bone, while after 2 months, a relevant decrease was observed. Histomorphometric analysis suggested that after orthodontic extrusion, a period of stabilization of 2 months allows the neo-deposed bone to mature.