■尽管对成人高尿酸血症(HUA)进行了广泛的研究,仍然缺乏研究这种情况下,在青年。因此,我们的目的是调查HUA在美国年轻人中的患病率,以及识别相应的危险因素。
■这项研究采用了美国国家健康和营养调查(NHANES)在2017年1月至2020年3月之间进行的1,051名13-20岁青年的全国代表性子样本。单变量和多变量技术被用来检查HUA和肥胖之间的关联,膳食营养素,肝肾功能,葡萄糖和脂质代谢,炎症,以及青少年人口中的其他指标。
■该研究涵盖了1,051名13-20岁的青年,包括538名男孩和513名女孩。HUA的总体患病率为7%(1,051人中有74人)。单因素分析显示,HUA组表现出更大的年龄,体重指数(BMI),腰围(WC),臀围(HC),腰臀比(WHR)。此外,HUA组的肥胖患病率明显高于非HUA组(均p<0.05)。关于生化指标,尿素氮的水平,肌酐(Cr),丙氨酸氨基转移酶(ALT),谷氨酸草酸转氨酶(AST),γ-谷氨酰转移酶(GGT),总胆固醇(TC),甘油三酯(TG),和HSC反应蛋白(HsCRP)在HUA组明显高于非HUA组(均p<0.05)。使用二元物流回归的进一步分析表明,BMI(p=0.024,OR1.158,95CI1.019-1.316),ALT(p=0.020,OR1.032,95CI1.005-1.059),和Cr(p=0.016,OR1.028,95CI1.005-1.051)被确定为HUA的危险因素,在控制了年龄之后,性别,BMI,WC,HC,WHR,ALT,AST,GGT,TG,TC,Cr,HsCRP,其他指标。有趣的是,单因素和多因素分析均未发现膳食营养素与HUA风险之间存在关联(均P>0.05)。
■高BMI仍然是美国13-20岁青年HUA的主要危险因素,应密切监测ALT和Cr水平以及血清尿酸。
UNASSIGNED: Despite extensive research on hyperuricemia (HUA) in adults, there remains a dearth of studies examining this condition in youth. Consequently, our objective was to investigate the prevalence of HUA among youth in the United States, as well as identify the corresponding risk factors.
UNASSIGNED: This study employed a nationally representative subsample of 1,051 youth aged 13-20 from the US National Health and Nutrition Examination Survey (NHANES) conducted between January 2017 and March 2020. Univariate and multivariate techniques were utilized to examine the association between HUA and obesity, dietary nutrients, liver and kidney function, glucose and lipid metabolism, inflammation, and other indicators in the adolescent population.
UNASSIGNED: The study encompassed a cohort of 1,051 youth aged 13-20 years, comprising 538 boys and 513 girls. The overall prevalence of HUA was found to be 7% (74 out of 1,051). Univariate analysis revealed that the HUA group exhibited greater age, body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR). Additionally, the prevalence of obesity was significantly higher in the HUA group compared to the non- HUA group (all p < 0.05). Regarding biochemical indicators, the levels of urea nitrogen, creatinine (Cr), alanine aminotransferase (ALT), glutamic oxalic aminotransferase (AST), gamma-glutamyl transferase (GGT), total cholesterol (TC), triglyceride (TG), and HS C reactive protein (Hs CRP) were found to be significantly higher in the HUA group compared to the non-HUA group (all p < 0.05). Further analysis using binary logistics regression showed that BMI (p = 0.024, OR1.158, 95%CI1.019-1.316), ALT (p = 0.020, OR1.032, 95%CI1.005-1.059), and Cr (p = 0.016, OR1.028, 95%CI1.005-1.051) were identified as risk factors for HUA, after controlling for age, gender, BMI, WC, HC, WHR, ALT, AST, GGT, TG, TC, Cr, Hs CRP, and other indicators. Interestingly, neither univariate nor multivariate analysis found any association between dietary nutrients and the risk of HUA (all p > 0.05).
UNASSIGNED: High BMI remains a major risk factor for HUA in US youth aged 13-20 years, and ALT and Cr levels should be closely monitored along with serum uric acid.