在北极,持续的有机污染物暴露是有据可查的,但是研究非持久性化学物质的研究较少,尽管市场食品和消费品消费增加。
要测量苯酚,对羟基苯甲酸酯,邻苯二甲酸酯,和因纽特人的替代增塑剂浓度。
该研究包括来自Qanuilirpitaa?2017Nunavik因纽特人健康调查(Q2017)参与者的30份尿液样本。肌酸酐调整的几何平均浓度(GM)和95%置信区间(CI)在性别之间进行比较,年龄,和地区,并与加拿大卫生措施调查(CHMS)和原住民生物监测倡议(FNBI)中的数据进行了比较。
2017季度双酚A浓度是2018-2019年CHMS浓度的两倍[GM(95%CI):1.98(1.69-2.31)与0.71(0.60-0.84)µg/g肌酐],但符合FNBI[1.74(1.41-2.13)µg/g肌酐]。与CHMS相比,Q2017中的几种邻苯二甲酸酯浓度较高,特别是邻苯二甲酸单苄基酯,2017年季度比2018-2019年CHMS高19倍[45.26(39.35-52.06)比2.4(2.0-2.9)µg/g肌酐],比FNBI高4倍。与CHMS2018-2019年相比,2017年第4季度的两种替代增塑剂2,2,4-三甲基-1,3-戊二醇二异丁酸酯(TIXB)代谢物的浓度也高出四倍。居住在Ungava湾的妇女和人们的非持久性化学物质浓度通常较高。
结果表明,与加拿大普通人群相比,因纽特人中某些非持久性化学物质的浓度更高。
很少有研究探索北方社区的非持久性化学物质分布,尽管消费者产品和市场食品消费不断增加。我们分析了来自Qanuilirpitaa?Nunavik因纽特人2017年健康调查的30个汇总样本,以评估对常见增塑剂和塑料成分的暴露,并将其水平与加拿大普通人群和原住民群体进行比较。我们观察到双酚A的含量特别高,邻苯二甲酸单苄基酯,与加拿大普通人群相比,Nunavimmiut中的两种2,2,4-三甲基-1,3-戊二醇二异丁酸酯(TXIB)代谢物,尤其是妇女和Ungava湾居民。需要更大规模的研究来确认我们的发现,并确定这些暴露对健康的潜在不利影响。
Persistent organic pollutant exposures are well-documented in the Arctic, but fewer studies examined non-persistent chemicals, despite increased market food and consumer product consumption.
To measure phenol, paraben, phthalate, and alternative plasticizer concentrations in Inuit adults.
The study included 30 pooled urine samples from Qanuilirpitaa? 2017 Nunavik Inuit Health Survey (Q2017) participants. Creatinine-adjusted geometric mean concentrations (GM) and 95% confidence intervals (CI) were compared across sex, age, and regions, and compared to those in the Canadian Health Measures Survey (CHMS) and the First Nations Biomonitoring Initiative (FNBI).
Q2017 bisphenol-A concentrations were double the CHMS 2018-2019 concentrations [GM (95% CI): 1.98 (1.69-2.31) versus 0.71 (0.60-0.84) µg/g creatinine], but in line with FNBI [1.74 (1.41-2.13) µg/g creatinine]. Several phthalate concentrations were higher in Q2017 versus CHMS, particularly monobenzyl phthalate, which was was 19-fold higher in Q2017 versus CHMS 2018-2019 [45.26 (39.35-52.06) versus 2.4 (2.0-2.9) µg/g creatinine] and four-fold higher than FNBI. There were also four-fold higher concentrations of the two alternate plasticizer 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TIXB) metabolites in Q2017 compared to CHMS 2018-2019. Women and people living in Ungava Bay had generally higher concentrations of non-persistent chemicals.
The results suggest higher concentrations of certain non-persistent chemicals in Inuit versus the general Canadian population.
Few studies have explored non-persistent chemical distributions in Northern communities, despite the increasing consumer product and market food consumption. We analyzed 30 pooled samples from the Qanuilirpitaa? Nunavik Inuit Health Survey 2017 to assess exposures to common plasticizes and plastic constituents and compare their levels with the general Canadian population and First Nation groups. We observed particularly higher levels of bisphenol-A, of monobenzyl phthalate, and of two 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB) metabolites among Nunavimmiut compared to the general Canadian population, notably among women and Ungava Bay residents. Larger studies are required to confirm our findings and identify potential adverse health effects from these exposures.