biases

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  • 文章类型: Journal Article
    The Machine Learning Model (MLM) has garnered popularity in rehabilitation, ranging from developing algorithms in outcome prediction, prognostication, and training artificial intelligence. High-quality data plays a critical role in algorithm development. Limited studies have explored factors that may influence the MLM algorithm performance in predicting spasticity severity level. The objectives of this study were to train and validate a MLM algorithm for spasticity assessment and determine the algorithm\'s prediction performance in predicting ambiguous spasticity datasets. Forty-seven persons with central nervous system pathology that fulfilled the inclusion and exclusion criteria were recruited. Four biomechanical properties of spasticity were obtained using off-the-shelf wearable sensors. The data were analyzed individually, and ambiguous datasets were separated. The acceptable inertial data were used to train and validate MLM in predicting spasticity. The trained and validated MLM algorithm was later deployed to predict the ambiguous spasticity datasets. A series of MLM were applied, including Support Vector Machine, Decision Tree, and Random Forest. The MLM\'s performance accuracy of the validation data was 96%, 52%, and 72%, respectively. The validated MLM accuracy performance level predicting ambiguous datasets reduces to 20%, 23%, and 23%, respectively. This study elucidates data biases and variances of disease background, pathophysiological and anatomical factors that have to be considered in MLM training.
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  • 文章类型: Journal Article
    缺乏代表性的冠状病毒病2019(COVID-19)数据是可靠和可推广的机器学习的瓶颈。没有数据质量,数据共享不足,其中源变异性起着重要作用。我们展示并讨论了COVID-19机器学习数据源可变性的潜在偏见。
    我们使用了公开的nCov2019数据集,包括来自多个国家的患者水平数据。我们旨在使用症状和合并症来发现和分类严重程度亚组。
    来自2个患病率最高的国家的病例被分为不同的亚组,具有不同的严重程度表现。这种可变性可以降低训练数据相对于模型目标群体的代表性,并增加过拟合风险的模型复杂性。
    数据源的可变性是导致分布式研究网络偏差的潜在因素。我们呼吁对COVID-19数据共享中的数据源变异性和数据质量进行系统评估和报告,作为可靠和可推广的机器学习的关键信息。
    The lack of representative coronavirus disease 2019 (COVID-19) data is a bottleneck for reliable and generalizable machine learning. Data sharing is insufficient without data quality, in which source variability plays an important role. We showcase and discuss potential biases from data source variability for COVID-19 machine learning.
    We used the publicly available nCov2019 dataset, including patient-level data from several countries. We aimed to the discovery and classification of severity subgroups using symptoms and comorbidities.
    Cases from the 2 countries with the highest prevalence were divided into separate subgroups with distinct severity manifestations. This variability can reduce the representativeness of training data with respect the model target populations and increase model complexity at risk of overfitting.
    Data source variability is a potential contributor to bias in distributed research networks. We call for systematic assessment and reporting of data source variability and data quality in COVID-19 data sharing, as key information for reliable and generalizable machine learning.
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  • 文章类型: Clinical Trial Protocol
    大量强迫症(OCD)患者没有接受暴露和反应预防的认知行为治疗,这是强迫症最有效的治疗方法。因此,OCD的元认知训练(MCT-OCD)被开发出来,这是一种结构化的团体疗法,旨在改善功能失调(元)认知偏见,信仰和应对方式。它可以由训练有素的人员管理,因此可能达到更多的患者。一项不受控制的先导研究(MCT-OCD先导版)提供了第一个证据,表明该训练已被患者高度接受;OC症状降低,效果较高(η2部分=0.50)。本研究的目的是解决试点研究的缺点(例如,无对照组),并在随机对照试验框架内评估MCT-OCD修订版的疗效。
    将招募80名强迫症患者。在基线(-t1)进行盲法评估后,患者将被随机分配至干预组(MCT-OCD;n=40)或照常治疗对照组(n=40).MCT-OCD旨在通过解决与OCD相关的功能失调(元)认知偏见和信念来提高八个模块中患者的元认知能力(例如,不容忍不确定性)。8周后,患者将被邀请参加后期评估(t1),然后他们将在t1(t2)后3个月收到一份后续在线问卷。主要结果是Y-BOCS总分,次要结果包括HDRS,OCI-R,OBQ-44,MCQ-30,WHOQOL-BREF,BDI-II,以及MCT-OCD的主观评价等级。我们预计从-t1到t1,与照常护理对照组相比,干预组的OC症状将减少更多,并且治疗收益将保持到t2。
    计划中的研究是第一个研究MCT-OCD,一种有希望的新疗法,在一项随机对照试验中。MCT-OCD可能有助于克服OCD患者的现有治疗障碍。
    德国临床研究注册中心(DRKS00013539),22.02.2018.
    A high number of patients with obsessive-compulsive disorder (OCD) do not receive cognitive-behavioral therapy with exposure and response prevention, which is the most effective treatment for OCD. Therefore, Metacognitive Training for OCD (MCT-OCD) was developed, which is a structured group therapy aiming at the modification of dysfunctional (meta-)cognitive biases, beliefs and coping styles. It can be administered by less trained personnel, thus may reach a higher number of patients. An uncontrolled pilot study (MCT-OCD pilot version) provided first evidence that the training is highly accepted by patients; OC symptoms decreased with a high effect size (η2partial = 0.50). The aim of the present study is to address the shortcomings of the pilot study (e.g., no control group) and to assess the efficacy of the revised version of the MCT-OCD in the framework of a randomized controlled trial.
    Eighty patients with OCD will be recruited. After a blinded assessment at baseline (-t1), patients will be randomly assigned either to the intervention group (MCT-OCD; n = 40) or to a care as usual control group (n = 40). The MCT-OCD aims to enhance patients\' metacognitive competence in eight modules by addressing dysfunctional (meta-)cognitive biases and beliefs associated with OCD (e.g., intolerance of uncertainty). After 8 weeks, patients will be invited to a post assessment (t1), and then they will receive a follow-up online questionnaire 3 months following t1 (t2). The primary outcome is the Y-BOCS total score, and the secondary outcomes include the HDRS, OCI-R, OBQ-44, MCQ-30, WHOQOL-BREF, BDI-II, and subjective appraisal ratings of the MCT-OCD. We expect that OC symptoms will decrease more in the intervention group compared with the care as usual control group from -t1 to t1 and that treatment gains will be maintained until t2.
    The planned study is the first to investigate the MCT-OCD, a promising new treatment, in a randomized controlled trial. The MCT-OCD may help to overcome existing treatment barriers for patients with OCD.
    German Registry for Clinical Studies ( DRKS00013539 ), 22.02.2018.
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  • 文章类型: Letter
    The aim of this Letter to the Editor was to report some important biases in a recently published Article. We agreed with the notion by Yamamoto et al. that the effects of epinephrine regarding was limited without hemostasis, however, this study had major limitations such as no information on etiology of traumatic cardiac arrest (hemorrhagic or on non-hemorrhagic) and on hemostatic treatment. The results of this study should be interpreted with caution and further analysis is necessary. Finally, we commented on the necessity of future study regarding another vasopressor (ie; vasopressin) on traumatic cardiac arrest based on current evidence.
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  • 文章类型: Journal Article
    I call the attention of psychologists to the pivotal role of cultural psychology in extending and enriching research programs. I argue that it is not enough to simply acknowledge the importance of culture and urge psychologists to practice cultural psychology in their research. I deconstruct five assumptions about cultural psychology that seriously undermine its contribution to the building of a true psychological science, including that cultural psychology (a) is only about finding group differences, (b) does not appertain to group similarities, (c) concerns only group-level analysis, (d) is irrelevant to basic psychological processes, and (e) is used only to confirm the generalizability of theories. I discuss how cultural psychology can provide unique insights into psychological processes and further equip researchers with additional tools to understand human behavior. Drawing lessons from the 20 years of cultural research that my colleagues and I have done on the development of social cognition, including autobiographical memory, future thinking, self, and emotion knowledge, I demonstrate that incorporating cultural psychology into research programs is not only necessary but also feasible.
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  • 文章类型: Journal Article
    The critical evaluation of an article enables professionals to make good use of the new information and therefore has direct repercussions for the benefit of our patients. Before undertaking a detailed critical reading of the chosen article, we need to consider whether the study used the most appropriate design for the question it aimed to answer (i.e., whether the level of evidence is adequate). To do this, we need to know how to classify studies in function of their design (descriptive or analytical; prospective or retrospective; cross-sectional or longitudinal) as well as their correlation with the levels of evidence. In critical reading it is also important to know the main systematic errors or biases that can affect a study. Biases can appear in any phase of a study; they can affect the sample, the development of the study, or the measurement of the results.
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  • 文章类型: Journal Article
    在这项研究中,我们分析了从机会主义,计划外,以及伊比利亚半岛北部地区的非标准化收集事件。使用存放在奥维耶多大学BOS节肢动物馆藏中的标本,我们将这些数据与计划中的数据进行了比较,标准化,以及在同一区域的多个位置具有陷阱陷阱的周期性集合。节肢动物收藏,始于1977年,包括来自两种采样类型的标本,它最近的数字化允许这种类型的比较分析。因此,这是第一份采用混合方法的数据论文,其中子集元数据与比较分析一起描述。完整的数据集可以通过西班牙GBIFIPT访问http://www。gbif.es:8080/ipt/archive.r=Bos-Opi,以及http://www上计划外收集事件的元数据。gbif.ES:8080/ipt/资源。do?r=bos-opi_unplanned_collection_events。我们已经绘制了计划外收集中包含的18种收割者物种的数据,并首次提供了六个省某些物种的记录。我们还提供了八个省的Phalangiumopilio的地点,但没有公布记录。这些结果强调了将计划外的生物多样性收集数据数字化的重要性,以及那些来自计划收藏的,尤其是在很少研究的群体和地区。
    In this study, we analyse the relevance of harvestmen distribution data derived from opportunistic, unplanned, and non-standardised collection events in an area in the north of the Iberian Peninsula. Using specimens deposited in the BOS Arthropod Collection at the University of Oviedo, we compared these data with data from planned, standardised, and periodic collections with pitfall traps in several locations in the same area. The Arthropod Collection, begun in 1977, includes specimens derived from both sampling types, and its recent digitisation allows for this type of comparative analysis. Therefore, this is the first data-paper employing a hybrid approach, wherein subset metadata are described alongside a comparative analysis. The full dataset can be accessed through Spanish GBIF IPT at http://www.gbif.es:8080/ipt/archive.do?r=Bos-Opi, and the metadata of the unplanned collection events at http://www.gbif.es:8080/ipt/resource.do?r=bos-opi_unplanned_collection_events. We have mapped the data on the 18 harvestmen species included in the unplanned collections and provided records for some species in six provinces for the first time. We have also provided the locations of Phalangium opilio in eight provinces without published records. These results highlight the importance of digitising data from unplanned biodiversity collections, as well as those derived from planned collections, especially in scarcely studied groups and areas.
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