肌内脂肪(IMF)沉积对肉牛生产中的肉质量和经济价值产生了深远的影响。同时,表观遗传学的当代发展为理解国际货币基金组织监管的分子基础开辟了新的前景,它已经成为世界学者研究的重点领域。因此,本文的目的是提供有关肉牛表观遗传机制与IMF沉积之间复杂关系的见解和综合。该方法涉及对现有文献的彻底分析,包括相关的书籍,学术期刊,和在线资源,全面概述表观遗传研究在肉牛IMF沉积中的作用。这篇综述总结了IMF调控中表观遗传机制的当代研究,高分辨率表观基因组作图,单细胞表观基因组学,多组学整合,表观基因组编辑方法,牛生长的纵向研究,环境表观遗传学,表观遗传学中的机器学习,道德和监管方面的考虑,并从IMF在肉牛中的沉积角度转化为行业实践。此外,本文重点介绍了DNA甲基化,组蛋白修饰,乙酰化,磷酸化,泛素化,非编码RNA,DNA羟甲基化,表观遗传读者,作家,和橡皮擦,染色质免疫沉淀,然后测序,全基因组亚硫酸氢盐测序,全表观基因组关联研究,以及它们对控制脂肪生成和脂质代谢的关键基因表达的深远影响。营养和应激对表观遗传修饰和IMF沉积也有显著影响。主要发现强调了表观遗传学研究在理解和增强肉牛中IMF沉积方面的关键作用,对精准畜牧业和伦理畜牧业管理具有重要意义。总之,这篇综述强调了表观遗传途径和环境因素在影响肉牛IMF沉积中的重要意义,为提高牛生产的经济性和肉质提供有见地的信息。
Intramuscular fat (IMF) deposition profoundly influences meat quality and economic value in beef cattle production. Meanwhile, contemporary developments in epigenetics have opened new outlooks for understanding the molecular basics of IMF regulation, and it has become a key area of research for world scholars. Therefore, the aim of this paper was to provide insight and synthesis into the intricate relationship between epigenetic mechanisms and IMF deposition in beef cattle. The methodology involves a thorough analysis of existing literature, including pertinent books, academic journals, and online resources, to provide a comprehensive overview of the role of epigenetic studies in IMF deposition in beef cattle. This
review summarizes the contemporary studies in epigenetic mechanisms in IMF regulation, high-resolution epigenomic mapping, single-cell epigenomics, multi-omics integration, epigenome editing approaches, longitudinal studies in cattle growth, environmental epigenetics, machine learning in epigenetics, ethical and regulatory considerations, and translation to industry practices from perspectives of IMF deposition in beef cattle. Moreover, this paper highlights DNA methylation, histone modifications, acetylation, phosphorylation, ubiquitylation, non-coding RNAs, DNA hydroxymethylation, epigenetic readers, writers, and erasers, chromatin immunoprecipitation followed by sequencing, whole genome bisulfite sequencing, epigenome-wide association studies, and their profound impact on the expression of crucial genes governing adipogenesis and lipid metabolism. Nutrition and stress also have significant influences on epigenetic modifications and IMF deposition. The key findings underscore the pivotal role of epigenetic studies in understanding and enhancing IMF deposition in beef cattle, with implications for precision livestock farming and ethical livestock management. In conclusion, this
review highlights the crucial significance of epigenetic pathways and environmental factors in affecting IMF deposition in beef cattle, providing insightful information for improving the economics and meat quality of cattle production.