氧化平衡评分(OBS)可用于表示个体中氧化应激的总体负担。本研究旨在探讨OBS与卒中风险之间的关系。
■使用1999年至2018年的国家健康与营养检查调查（NHANES）为参加中风问卷的参与者提取了一系列变量。OBS的建设依赖于饮食和生活方式的组成部分，其中包括16种营养素和4种生活方式因素。采用加权多变量调整逻辑回归分析卒中风险与OBS之间的关系。还进行了分层分析。卒中风险与OBS之间的剂量反应关系通过执行有限的三次样条函数来阐明。
■总共20,680名参与者被纳入分析，其中768人患有中风。基于加权多变量逻辑回归分析，我们发现，每增加一个OBS单位的卒中患病率下降2%[OR：0.98（0.97-1.00），P<0.01]。对于OBS子组，我们还发现，较高的OBS与卒中风险降低有关[第4季度与Q1：或：0.65（0.46-0.90），P<0.01]。在饮食中添加每个OBS单位，中风的患病率下降了3％[OR：0.97（0.96-0.99），P<0.01]。对于饮食OBS亚组，饮食成分中OBS升高与卒中患病率降低相关[Q4与Q1：或：0.65，（0.47-0.91），P<0.05]。进一步的分层分析显示，每增加一个OBS单位与卒中患病率下降有关，这在≥60岁的亚组中具有统计学意义，女性,无糖尿病和无高血压。OBS与卒中患病率呈线性关系。
■研究发现，OBS升高与卒中患病率下降有关，这可能是评估中风风险的重要指标。
UNASSIGNED: The oxidative balance score (OBS) can be used to represent the overall burden of oxidative stress in an individual. This
study aimed to explore the association between the risk of stroke and OBS.
UNASSIGNED: The National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 was used to extract a series of variables for participants who took the stroke questionnaire. The construction of OBS relied on diet and lifestyle components, which included 16 nutrients and 4 lifestyle factors. Weighted multivariable-adjusted logistic regression was performed to investigate the association between stroke risk and OBS. A stratified analysis was also conducted. The dose-response relationship between stroke risk and OBS was elucidated by performing a restricted cubic spline function.
UNASSIGNED: A total of 20,680 participants were included for analysis, 768 of whom suffered from stroke. Based on weighted multivariable logistic regression analysis, we discovered that the stroke prevalence decreased by 2% for each OBS unit added [OR: 0.98 (0.97-1.00), P < 0.01]. For the OBS subgroup, we also discovered that higher OBS was related to a reduction in the risk of stroke [Q4 vs. Q1: OR:0.65 (0.46-0.90), P < 0.01]. The prevalence of stroke declined by 3% with every OBS unit added to the diet component [OR: 0.97 (0.96-0.99), P < 0.01]. For the dietary OBS subgroup, higher OBS in diet components was associated with a decrease in the prevalence of stroke [Q4 vs. Q1: OR: 0.65, (0.47-0.91), P < 0.05]. Further stratified analysis showed that every OBS unit raised was associated with a decline in stroke prevalence, which was statistically significant in participants in subgroups of ≥60 years, female, no-diabetes mellitus and no-hypertension. OBS and stroke prevalence were correlated in a linear manner.
UNASSIGNED: The
study found that a higher OBS was associated with a decrease in stroke prevalence, which could be a significant indicator for evaluating stroke risk.
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