■近几十年来,非结核分枝杆菌(NTM)感染的发病率大幅上升.然而,全球NTM的诊断和管理面临重大挑战,特别是在涉及脓肿分枝杆菌复合体(MABC)感染的病例中,有效的治疗选择有限。
我们报道了一名38岁的女性患者,因美容院的“美容针”而感染了MABC的皮肤,双颊上有肿块,伴随着红肿,和痛苦,其中一些被切除了。从双侧脸颊肿块多次穿刺抽脓,用“甲硝唑”冲洗,口服“头孢菌素”治疗无效。因此,她来到我们医院。通过核酸质谱检测脓肿穿刺脓液中的MABC,并由脓液的培养结果证明。因此,患者被诊断为皮肤MABC感染,并采取抗NTM治疗。然而,不良反应,如耳鸣,在初始治疗期间发生肝毒性和神经毒性。在调整到含有康奈唑胺的方案后,这些不良反应有所改善。经过近6个月的治疗,面颊肿块逐渐减少,皮肤破裂逐渐愈合。随访10个月,患者面部症状明显改善,无药物相关不良反应发生。
■这是使用含有康奈唑胺的抗生素管理策略治疗的皮肤多重耐药性MABC感染的首例成功病例,在这种顽固性疾病中表现出显著的疗效和良好的安全性。
UNASSIGNED: In recent decades, there has been a substantial surge in the incidence of non-tuberculous Mycobacteria (NTM) infections. However, the diagnosis and management of NTM globally present significant challenges, particularly in cases involving Mycobacterium abscessus complex (MABC) infection where effective therapeutic options are limited.
UNASSIGNED: We reported a 38-year-old female patient who was infected with MABC of skin due to \"beauty needle\" at a beauty salon, with mass on both cheeks, accompanied by redness, and pain, and some of them was ulcered and effused. Puncture pumping pus from bilateral cheek mass for many times, rinsed with \"metronidazole\", and oral \"cephalosporin\" treatment did not work. Therefore, she came to our hospital. MABC was detected in abscess paracentesis pus by nucleic acid mass spectrometry, and was proved by the cultured result of the pus. Thus, the patient was diagnosed as skin MABC infection, and anti-NTM treatment was taken. However, adverse reactions such as tinnitus, hepatotoxicity and neurovirulence occurred during the initial treatment. After adjusting to the contezolid-containing regimen, these adverse reactions improved. After nearly 6 months of treatment, the cheek mass was gradually reduced and the skin ruptures were gradually healed. Follow-up for 10 months showed that the patient\'s facial symptoms were significantly improved, and no drug-related adverse reactions happened.
UNASSIGNED: This was the first successful
case of multiple drug resistance MABC infection of skin treated with contezolid-containing antibiotic management strategies, which exhibited remarkable efficacy and good safety in this intractable disease.