{Reference Type}: Journal Article
{Title}: Risk factors for Pseudomonas aeruginosa VIM colonization/infection in the ICU: Case control study.
{Author}: Assaad C;Chaibi K;Jaureguy F;Plésiat P;Carbonnelle E;Cohen Y;Zahar JR;Pilmis B;
{Journal}: Am J Infect Control
{Volume}: 0
{Issue}: 0
{Year}: 2024 Jun 24
{Factor}: 4.303
{DOI}: 10.1016/j.ajic.2024.06.013
{Abstract}: <B>BACKGROUND: </B>Carbapenem-resistant strains of Pseudomonas aeruginosa (CRPA) have become a major healthcare concern in many countries, against which anti-infective strategies are limited and which require adequate infection control interventions. Knowing the different modes of transmission of CRPA in intensive care units (ICUs) would be helpful to adapt the means of prevention.<BR><B>METHODS: </B>The aim of this retrospective case-control study was conducted between 01/01/2017 and 02/28/2022 to identify the risk factors for the acquisition of CRPA in ICUs.<BR><B>RESULTS: </B>During the study period, 147 patients were included (49 cases and 98 controls). Among the 49 patients, 31 (63%) acquired CRPA in clusters and 18 (37%) sporadically. An univariate analysis showed that five variables were associated with CRPA acquisition including (i) prior antibiotic prescriptions, (ii) admission to rooms 203 and 207, (iii) severity of illness at admission, and (iv) use of mechanical ventilation. Multivariate analysis identified three factors of CRPA acquisition including admission to room 203 (OR = 29.5 [3.52-247.09]), previous antibiotic therapy (OR = 3.44 [1.02 - 11.76]) and severity of condition at admission (OR = 1.02 [1 - 1.04]).<BR><B>CONCLUSIONS: </B>Our study suggests the role of a contaminated environment in the acquisition of CRPA in the ICU, along with antibiotic use.