背景:对后房型有晶状体植入式Collamer晶状体(ICL)后影响拱顶的因素进行了研究,但大多数都是单中心和主观的参数选择。本研究旨在系统分析保险库的影响因素。
方法:对病例系列的系统评价,病例控制,以及来自PubMed上发表的文章的队列研究,Cochrane图书馆,Embase,WebofScience,CNKI,CBM,万方和贵宾,以及临床试验,使用四个核心术语搜索拱顶因素的研究:有晶状体人工晶状体,保险库,危险因素和观察性研究,从1997年1月1日至2023年2月20日。对纳入的研究进行定量分析和定性描述。随后,使用meta回归和亚组分析。
结果:我们确定了13项研究(1,607名受试者),并考虑了14个因素。Meta分析显示前房深度(ACD),水平角膜白对白(hWTW),ICL-size,和年龄是异常穹顶的双重效应;前房容积(ACV)和晶状体厚度(LT)是单向效应;而轴向长度(AL),ICL-球面当量(ICL-SE)和Km不显著。此外,前房角(ACA)的描述性分析,水平沟到沟(hSTS),睫状突高度(T值),晶状体上升(CLR),和性别表明,除性别外,所有因素都对金库有显著影响。敏感性分析显示组合结果稳定。国家和设计分别影响低保险库ACD和ICL大小的异质性,而设计会影响高拱顶ACD的异质性。不存在出版偏见。
结论:ICL后的跳马与多种因素有关,尤其是前段生物学参数,它们的权重不同。希望为ICL的选择和调整提供参考。
BACKGROUND: Studies on the factors affecting vault after posterior chamber phakic Implantable Collamer Lens (ICL) have been carried out, but most of them are single-centered and subjective selections of parameters. The present study aimed to systematically analyze the factors for vault.
METHODS: A systematic
review of case series, case-control, and cohort studies derived from the articles published in PubMed, the Cochrane Library, Embase, Web of Science, CNKI, CBM, Wanfang and VIP, as well as ClinicalTrials, which were conducted to search for studies on factors of vault using four core terms: phakic intraocular lenses, vault, risk factor and observational study, from January 01, 1997, to February 20, 2023. The included studies were meta-analyzed quantitatively and described qualitatively. Subsequently, meta-regression and subgroup analysis were used.
RESULTS: We identified 13 studies (1,607 subjects), and 14 factors were considered. Meta-analysis showed that anterior chamber depth (ACD), horizontal corneal white-to-white (hWTW), ICL-size, and age are dual effects of the abnormal vaults; anterior chamber volume (ACV) and lens thickness (LT) are a one-way effect; while axial length (AL), ICL- spherical equivalent (ICL-SE) and Km are insignificant. In addition, descriptive analysis of anterior chamber angle (ACA), horizontal sulcus to sulcus (hSTS), ciliary processes height (T value), crystalline lens rise (CLR), and gender showed that all factors except gender tend to have significant effects on vault. Sensitivity analysis showed stable combined results. Country and design respectively affect the heterogeneity in ACD and ICL-size at low vault, while design affects the heterogeneity in ACD at high vault. No publication bias exists.
CONCLUSIONS: Vault after ICL is related to multiple factors, especially anterior segmental biologic parameters, and they are weighted differently. We hope to provide a reference for the selection and adjustment of ICL.