PDF(Pubmed)
Abstract：
This article aims to provide a comprehensive review of the biochemical changes observed in the anterior chamber of the eye in diabetic patients. The increased levels of inflammatory markers, alterations in antioxidant defense mechanisms, and elevated levels of advanced glycation end products (AGEs) in the aqueous humor (AH) are explored. Additionally, the impact of these biochemical changes on diabetic retinopathy progression, increased intraocular pressure, and cataract formation is discussed. Furthermore, the diagnostic and therapeutic implications of these findings are presented. This study explores potential biomarkers for detecting diabetic eye disease at an early stage and monitoring its progression. An investigation of the targeting of inflammatory and angiogenic pathways as a potential treatment approach and the role of antioxidant agents in managing these biochemical changes is performed.
摘要：
本文旨在全面回顾糖尿病患者眼前房的生化变化。炎症标志物水平升高，抗氧化剂防御机制的改变，并探讨了房水（AH）中晚期糖基化终产物（AGEs）的升高水平。此外,这些生化变化对糖尿病视网膜病变进展的影响，眼内压升高，并讨论了白内障的形成。此外，介绍了这些发现的诊断和治疗意义.这项研究探索了在早期阶段检测糖尿病眼病并监测其进展的潜在生物标志物。对作为潜在治疗方法的炎症和血管生成途径的靶向以及抗氧化剂在管理这些生化变化中的作用进行了研究。
