UNASSIGNED: Animal models are frequently used for translational research in Peyronie\'s disease (PD). However, due to lack of availability of guidelines, there is some heterogeneity in study design, data reporting, and outcome measures.
UNASSIGNED: This European Society for Sexual Medicine consensus statement aims to provide guidance in utilization of animal models in PD research in a standardized and uniform fashion.
UNASSIGNED: PubMed was searched for studies using animal models for PD. The following search terms were used: (\"Peyronie\'s disease\" OR \"penile fibrosis\" OR \"penile curvature\" OR \"induration penis plastica\" OR \"erectile dysfunction\") AND (\"rodent\" OR \"mouse\" OR \"mice\" OR \"rat\" OR \"rabbit\").
UNASSIGNED: This European Society for Sexual Medicine statement describes best practice guidelines for utilization of animals in PD research: power calculation, details of available models, surgical procedures, and measurement techniques, while highlighting possible pitfalls and translational limitations of the models.
UNASSIGNED: In total, 2490 studies were retrieved and 2446 articles were excluded. A total of 44 studies were included, of which 40 studies used rats, 1 study used both rats and mice, 1 study used a genetic mouse model, and 2 studies used rabbits. A significant number of the studies (70.5%) used transforming growth factor β 1 for induction of fibrosis. Oxford 2011 Levels of Evidence criteria could not be applied due to the nature of the studies.
UNASSIGNED: Despite certain limitations of PD animal models presented, we aimed to provide guidance for their appropriate use in translational research, with the purpose of improving study quality and reproducibility as well as facilitating interpretation of reported results and conclusions.

Background and Objective: Translational large animal models are inevitable to transfer cartilage repair methods into clinical practice. Guidelines for these trials have been published by guiding agencies (FDA, ASTM, EMEA) including recommendations for study descriptors and study outcomes. However, practical adherence to these recommendations is not achieved in all aspects. This study includes an assessment of the recommended aspects regarding practical relevance in large animal models for cartilage repair by professionals in the field. Materials and Methods: In an online based survey, 11 aspects regarding study design and 13 aspects regarding study outcome from previously published guidelines were evaluated (0-10 points, with 10 being most important) by study participants. Additionally, the survey contained questions related to professional experience (years), professional focus (preclinical, clinical, veterinarian, industry) and the preferred translational large animal model for cartilage repair. Results: The total number of survey participants was 37. Rated as most important for study design parameters was lesion size (9.54 pts., SD 0.80) followed by study duration (9.43 pts., SD 1.21); and method of scaffold fixation (9.08 pts., SD 1.30) as well as depth of the lesion (9.03 pts., SD 1.77). The most important aspects of study outcome were considered histology (9.41 pts., SD 0.86) and defect filling (8.97 pts., SD 1.21), while gene expression was judged as the least important (6.11 pts., SD 2.46) outcome. A total of 62.2% of all participants were researchers, 18.9% clinicians, 13.5% veterinarians and 5.4% industry employees. Conclusions: In translational research, recommendations published by guiding agencies receive broad theoretical consensus within the community, including both clinically and preclinically orientated scientists. However, implementation into practical research lacks in major aspects. Ongoing re-evaluation of the guidelines under involvement of all stakeholders and approaches to overcome financial and infrastructural limitations could support the acceptance of the guidance documents and contribute to standardization in the field.

BACKGROUND: Rodent animal models are currently the most used in vivo model in translational studies looking into the pathophysiology of erectile dysfunction after nerve-sparing radical prostatectomy.
OBJECTIVE: This European Society for Sexual Medicine (ESSM) statement aims to guide scientists toward utilization of the rodent model in an appropriate, timely, and proficient fashion.
METHODS: MEDLINE and EMBASE databases were searched for basic science studies, using a rodent animal model, looking into the consequence of pelvic nerve injury on erectile function.
METHODS: The authors present a consensus on how to best perform experiments with this rodent model, the details of the technique, and highlight possible pitfalls.
RESULTS: Owing to the specific issue-basic science-Oxford 2011 Levels of Evidence criteria cannot be applied. However, ESSM statements on this topic will be provided in which we summarize the ESSM position on various aspects of the model such as the use of the Animal Research Reporting In Vivo Experiments guideline and the of common range parameter for nerve stimulation. We also highlighted the translational limits of the model.
CONCLUSIONS: The following statements were formulated as a suggestive guidance for scientists using the cavernous nerve injury model. With this, we hope to standardize and further improve the quality of research in this field. It must be noted that this model has its limitations. Weyne E, Ilg MM, Cakir OO, et al. European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction. Sex Med 2020;8:327-337.

OBJECTIVE: Allergic rhinitis (AR) is a symptomatic disorder of the nose induced by allergen exposure, which triggers immunoglobulin E (IgE)-mediated inflammation of the nasal membranes. Allergic rhinitis is one of the most common health problems and has a major effect on the quality of life.
METHODS: In this review, we aimed to provide a consensus for experimental studies on allergic rhinitis in terms of allergic rhinitis models. For this purpose, we searched for experimental studies in the PubMed, Proquest Central, and Google electronic databases over a 20-year period from the current time (1996-2016). The literature survey was performed using keywords including \"allergic rhinitis\", \"experimental\", \"animal\", \"model\", \"rat\", \"rabbit\", \"guinea pig\", and \"mice\" alone or in various combinations. The search identified a total of 285 papers, which were included in this review.
RESULTS: It is vital to select a suitable animal for an allergic model. Rodents like rats, guinea pigs, and mice can produce allergen-specific antibodies with the use of adjuvants. Rats are cheap and the vast majority of the allergen-specific antibodies are immunoglobulin E (IgE). Still, intraperitoneal sensitization is inescapable and adjuvants are required for sensitization. Rats, mice, rabbits, and guinea pigs can be utilized for this reason.
CONCLUSIONS: This review presented allergic rhinitis models in rats, mice, guinea pigs, and rabbits. Using these methods, researchers may perform well-designed studies.