已在阿尔茨海默病痴呆的背景下检查了血浆磷脂酰胆碱(PC)。然而,它们与淀粉样蛋白沉积纵向变化的关系尚不清楚。本研究调查了8种血浆PC水平的关联(PCaa[14:0_14:0],PCaa[16:0_16:0],PCaa[16:0_18:2],PCaa[16:0_22:6],PCaa[18:0_18:0],PCaa[18:0_18:1],PCaa[18:0_20:4],PCaa[18:1_18:1])用淀粉样蛋白沉积的横截面和纵向测量,阿尔茨海默病相关的神经变性(葡萄糖代谢和皮质厚度),1440名认知未受损的参与者(47%为女性,50.7-95.3岁)在梅奥诊所衰老研究中。纵向,较高的PCaa基线水平[16:0_18:2],PCaa[18:0_18:1],和PCaa[18:1_18:1]与全球认知和特定认知领域测试的表现下降较慢有关。此外,血浆PCaa的基线水平较高(14:0_14:0)与多个协变量调整后淀粉样蛋白沉积较慢和皮质变薄有关(年龄,性别,教育,医学共病,血脂异常,他汀类药物的使用,和APOE4等位基因的存在)。我们的研究结果支持认知未受损的老年人血浆PCaa(14:0_14:0)与淀粉样蛋白沉积较慢和皮质变薄之间的独立关联。
Plasma phosphatidylcholines (PCs) have been examined in the context of Alzheimer\'s disease dementia. However, their association with longitudinal changes in amyloid deposition remains unknown. This
study investigated the associations of 8 plasma PC levels (PC aa [14:0_14:0], PC aa [16:0_16:0], PC aa [16:0_18:2], PC aa [16:0_22:6], PC aa [18:0_18:0], PC aa [18:0_18:1], PC aa [18:0_20:4], PC aa [18:1_18:1]) with cross-sectional and longitudinal measures of amyloid deposition, Alzheimer\'s disease-associated neurodegeneration (glucose metabolism and cortical thickness), and cognition (global- and domain-specific) of 1440 cognitively unimpaired participants (47% female, aged 50.7-95.3 years) in the Mayo Clinic
Study of Aging. Longitudinally, higher baseline levels of PC aa [16:0_18:2], PC aa [18:0_18:1], and PC aa [18:1_18:1] were associated with slower decline in performance on tests of global cognition and specific cognitive domains. Furthermore, higher baseline levels of plasma PC aa (14:0_14:0) were associated with slower amyloid deposition and cortical thinning after multiple covariable adjustment (age, sex, education, medical comorbidity, dyslipidemia, statin use, and APOE4 allele presence). Our
study findings support an independent association between plasma PC aa (14:0_14:0) with slower amyloid deposition and cortical thinning among cognitively unimpaired older adults.