Abstract：
Gender, APOE ɛ4 status and age have different effects on brain amyloid deposition in patients with mild cognitively impaired (MCI).
To investigate the effect of gender×APOE ɛ4 status interaction on Aβ deposition in the brains of individuals with MCI in different age groups by PET scanning.
204 individuals with MCI were classified into younger or older groups based on whether they were under or over 65 years of age. APOE genotyping, structural MRI, amyloid PET scans, and neuropsychological tests were performed. The effect of gender×APOE ɛ4 status interaction on Aβ deposition was assessed in different age groups.
APOE ɛ4 carriers had higher amyloid deposition than noncarriers in the whole group. Females with MCI had more amyloid deposition in the medial temporal lobe than males in the whole cohort and younger group. Older individuals with MCI had higher amyloid deposition than younger individuals. In stratified analysis by age, female APOE ɛ4 carriers had significantly increased amyloid deposition compared to their male counterparts only in the medial temporal lobe in the younger group. Amyloid deposition was increased in female APOE ɛ4 carriers compared to noncarriers in the younger group, whereas higher amyloid deposition was observed in male APOE ɛ4 carriers in the older group.
Women in the younger group with MCI who were APOE ɛ4 carriers had more amyloid deposition in the brain, while men in the older group with MCI who were APOE ɛ4 carriers had higher amyloid deposition.
To investigate the effect of gender×APOE ɛ4 status interaction on Aβ deposition in the brains of individuals with MCI in different age groups by PET scanning.
204 individuals with MCI were classified into younger or older groups based on whether they were under or over 65 years of age. APOE genotyping, structural MRI, amyloid PET scans, and neuropsychological tests were performed. The effect of gender×APOE ɛ4 status interaction on Aβ deposition was assessed in different age groups.
APOE ɛ4 carriers had higher amyloid deposition than noncarriers in the whole group. Females with MCI had more amyloid deposition in the medial temporal lobe than males in the whole cohort and younger group. Older individuals with MCI had higher amyloid deposition than younger individuals. In stratified analysis by age, female APOE ɛ4 carriers had significantly increased amyloid deposition compared to their male counterparts only in the medial temporal lobe in the younger group. Amyloid deposition was increased in female APOE ɛ4 carriers compared to noncarriers in the younger group, whereas higher amyloid deposition was observed in male APOE ɛ4 carriers in the older group.
Women in the younger group with MCI who were APOE ɛ4 carriers had more amyloid deposition in the brain, while men in the older group with MCI who were APOE ɛ4 carriers had higher amyloid deposition.
摘要：
背景：性别，在轻度认知障碍（MCI）患者中，APOEä4状态和年龄对大脑淀粉样蛋白沉积有不同的影响。
目的：通过PET扫描研究不同年龄MCI患者脑内性别×APOE-4状态交互作用对Aβ沉积的影响。
方法：204名MCI患者根据年龄是否在65岁以下或以上分为较年轻或较老年组。APOE基因分型,结构MRI,淀粉样蛋白PET扫描，并进行了神经心理学测试。在不同年龄组评估了性别×APOEº4状态交互作用对Aβ沉积的影响。
结果：在整个组中，APOE®4携带者的淀粉样蛋白沉积高于非携带者。在整个队列和年轻组中，患有MCI的女性在内侧颞叶的淀粉样蛋白沉积比男性多。患有MCI的老年人比年轻人有更高的淀粉样蛋白沉积。在按年龄分层分析中，与年轻组的男性相比，女性APOEä4携带者仅在内侧颞叶中淀粉样蛋白沉积显着增加。与年轻组的非携带者相比，女性APOEº4携带者的淀粉样蛋白沉积增加，而在老年组的男性APOEä4携带者中观察到更高的淀粉样蛋白沉积。
结论：患有MCI的年轻女性中，APOEº4携带者的大脑中淀粉样蛋白沉积更多，而年龄较大的MCI患者中APOEº4携带者的淀粉样蛋白沉积较高。
目的：通过PET扫描研究不同年龄MCI患者脑内性别×APOE-4状态交互作用对Aβ沉积的影响。
方法：204名MCI患者根据年龄是否在65岁以下或以上分为较年轻或较老年组。APOE基因分型,结构MRI,淀粉样蛋白PET扫描，并进行了神经心理学测试。在不同年龄组评估了性别×APOEº4状态交互作用对Aβ沉积的影响。
结果：在整个组中，APOE®4携带者的淀粉样蛋白沉积高于非携带者。在整个队列和年轻组中，患有MCI的女性在内侧颞叶的淀粉样蛋白沉积比男性多。患有MCI的老年人比年轻人有更高的淀粉样蛋白沉积。在按年龄分层分析中，与年轻组的男性相比，女性APOEä4携带者仅在内侧颞叶中淀粉样蛋白沉积显着增加。与年轻组的非携带者相比，女性APOEº4携带者的淀粉样蛋白沉积增加，而在老年组的男性APOEä4携带者中观察到更高的淀粉样蛋白沉积。
结论：患有MCI的年轻女性中，APOEº4携带者的大脑中淀粉样蛋白沉积更多，而年龄较大的MCI患者中APOEº4携带者的淀粉样蛋白沉积较高。
