allograft

同种异体移植物
  • 文章类型: Case Reports
    经皮肾镜取石术是一种微创手术,用于设置复杂的结石负担。在其用途中,PCNL可用于治疗同种异体肾移植结石。此病例提出了独特的挑战,并罕见地使用了PCNL,其中涉及切除了2.6厘米的结石,该结石在43岁的男性中出现,患有双重肾脏同种异体移植物。同种异体移植物的独特位置提出了挑战,这些挑战通过平稳的术后过程和没有残留的结石负担来成功导航。文献中很少报道使用PCNL治疗双同种异体肾移植结石。
    Percutaneous Nephrolithotomy is a minimally-invasive procedure used in the setting of complex stone burden. Among its uses, PCNL can be employed to treated renal allograft calculi. This case presented a unique challenge and a rare usage of PCNL that involved removal of a 2.6 cm stone that presented in a 43-year-old male with dual renal allografts. The unique location of the allograft presented challenges that were navigated successfully with an uneventful postoperative course and no residual stone burden. The utilization of PCNL to treat calculi in dual renal allografts has been minimally reported in the literature.
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  • 文章类型: Case Reports
    这项研究介绍了一名40岁的男性患者在肾移植后的情况。CT扫描显示下腹部和骨盆有一个大肿块,右髂外动脉的分支与生长相交。经过全面检查,研究表明,肿块来自移植的肾脏,并进行了根治性肾切除术(包括肿块)。我们记录了一例发生在移植肾中的非典型血管平滑肌脂肪瘤(AAM)。本文报道了该病例的研究,并对其临床表现进行了简要的文献综述,AAM的诊断和治疗。
    This study presents the case of a 40-year-old male patient after renal transplantation. The CT scan revealed a large mass in the lower abdomen and pelvis, with a branch of the right external iliac artery intersecting the growth. After a comprehensive examination, it was shown that the mass originated from the transplanted kidney, and a radical nephrectomy (including the mass) was performed. We document a case of atypical angiomyolipoma (AAM) occurring in a transplanted kidney. This article reports the case study and a brief literature review of the clinical presentation, diagnosis and treatment of AAM.
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  • 文章类型: Journal Article
    在治疗胫骨平台骨折(TPF)时,必须恢复关节一致性并保持复位直至愈合。这项研究的主要目的是评估使用同种异体植骨(IBA)增强的可行性,以防止愈合过程中胫骨平台骨折的复位丢失并评估其掺入。
    我们回顾性分析了所有急性,闭合性胫骨平台骨折(SchatzkerII,III,IV)在2010年至2019年期间接受切开复位内固定(ORIF)和同种异体植骨(IBA)治疗,至少随访24个月。我们通过沿胫骨轴绘制一条线和垂直于健康平台的另一条线来评估术后X射线照片,以测量减少和随后的行为。通过放射学分析评估同种异体移植物的整合,非工会,再吸收,或硬化症。我们使用临床放射学Rasmussen系统和西安大略省和麦克马斯特大学骨关节炎指数(WOMAC)来客观化结果。
    包括78个TPF,中位年龄为51.5(40.7-62.2)岁,中位随访时间为66(24-89)个月。两名(2.5%)患者在手术中取得的随访期间出现关节复位(下沉)丢失。76例(94.7%)患者出现整合,两次(2.5%)吸收,和一个(1.3%)硬化症。72名(92.3%)患者在拉斯穆森放射学评分中表现优异和良好的结果,72例(92.3%)患者临床评分优异或良好。术后两年平均WOMAC为15±6.5。
    我们的结果表明,同种异体移植是维持II型减少的佐剂,III,和IVSchatzker胫骨平台骨折。使用它可以预期在随访期间降低的损失率较低。
    UNASSIGNED: Restoring joint congruence and maintaining reduction until healing is imperative in treating tibial plateau fractures (TPF). The main objective of this study was to evaluate the feasibility of augmentation with impacted bone allograft (IBA) to prevent loss of reduction in tibial plateau fractures during healing and to evaluate its incorporation.
    UNASSIGNED: We retrospectively analyzed all patients with an acute, closed tibial plateau fracture (Schatzker II, III, IV) treated between 2010 and 2019 with open reduction and internal fixation (ORIF) and impacted bone allograft (IBA), with a minimum follow-up of 24 months. We evaluated the postoperative radiographs by drawing a line along the tibial axis and another perpendicular to the healthy plateau to measure the reduction and subsequent behavior. The incorporation of the allograft was evaluated by radiological analysis assessing its integration, non-union, resorption, or sclerosis. We used the clinical-radiological Rasmussen system and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to objectify the outcomes.
    UNASSIGNED: 78 TPFs were included, with a median age of 51.5 (40.7-62.2) years and a median follow-up of 66 (24-89) months. Two (2.5 %) patients presented loss of joint reduction (subsidence) during the follow-up regarding the achieved in the surgery. Seventy-six (94.7 %) patients presented integration, two (2.5 %) resorption, and one (1.3 %) sclerosis. Seventy-two (92.3 %) patients presented excellent and good results in the Rasmussen radiological score, and 72 (92.3 %) patients presented excellent or good clinical scores. The mean WOMAC at two years postoperatively was 15 ± 6.5.
    UNASSIGNED: Our results demonstrate that allograft is an adjuvant in maintaining a reduction in type II, III, and IV Schatzker\'s tibial plateau fractures. Low rates of loss of reduction during follow-up can be expected with its use.
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  • 文章类型: Case Reports
    肱骨远端关节内粉碎性骨折是一种具有挑战性的损伤,与骨不连,感染和僵硬被认为是主要问题。我们报告了一名58岁的妇女,她因车祸进入急诊室,维持开放性伤口,肱骨远端严重粉碎,关节完全骨折,分类为AO/OTA13C2和GustilloAndersonIIIA型。首先进行清创和外固定,随后进行切开复位和同种异体腓骨支柱内固定。患者在放射学和功能方面表现出优异的结果。证据等级:V级(治疗)。
    Distal humerus intra-articular comminuted open fracture is a challenging injury, with nonunion, infection and stiffness considered as major concerns. We report a 58-year-old woman who was admitted to the emergency department from a car accident, sustaining an open wound with severe comminution of distal humerus and complete articular fracture, classified as AO/OTA 13C2 and Gustillo Anderson type IIIA. Debridement and external fixation was done first, followed by open reduction and internal fixation with fibular strut allograft. The patient showed excellent results in radiological and functional outcomes. Level of Evidence: Level V (Therapeutic).
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  • 文章类型: Case Reports
    UNASSIGNED: The extensor apparatus of the knee can be thought of a chain that transmits the muscular strength developed by the quadriceps muscles to the proximal tibia. This complex is essential to allow the extension of the tibia over the femur, being essential to provide knee mobility and stability. In case of lesions which irreparably damage the patella, such as a locally aggressive bone tumor, it is necessary to restore both the apparatus\' anatomical continuity and its strength.
    UNASSIGNED: A 39-years-old Caucasian man with a history of lung carcinoma developed atraumatic swelling and soreness in his left knee. Imaging evidence reported a degeneration of the left patella. We performed an en bloc resection of the patella and the nearby soft tissues of the extensor apparatus. The resulting gap was fulfilled with a massive allograft consisting of a quadriceps tendon, a patella and a patellar ligament. No complication or local recurrences were observed. At the patient\'s latest follow-up, he did not have any extension lag and quadriceps strength was completely restored.
    UNASSIGNED: Massive allografts can represent a reliable alternative for the reconstruction of the patella and the knee extensor apparatus in orthopedic oncology.
    UNASSIGNED: Kelio tiesiamąjį aparatą galima teigti esant grandine, kuri perduoda keturgalvio raumens raumenų sukurtą jėgą proksimaliniam blauzdikauliui. Šis kompleksas yra labai svarbus, kad blauzdikaulis galėtų išsitempti virš šlaunikaulio, ir yra būtinas kelio judrumui ir stabilumui užtikrinti. Esant pažeidimų, kurie negrįžtamai pažeidžia girnelę, pavyzdžiui, vietinio agresyvaus kaulų naviko atveju, būtina atkurti anatominį kelio tiesiamojo aparato vientisumą ir jo tvirtumą.
    UNASSIGNED: 39 metų baltaodžiui, kuriam anksčiau buvo diagnozuota plaučių karcinoma, atsirado kairės kojos kelio atraminis patinimas ir skausmingumas. Vaizdiniais duomenimis nustatėme kairiojo kelio girnelės degeneraciją. Atlikome en bloc kelio girnelės ir šalia esančio tiesiamojo aparato minkštųjų audinių rezekciją. Atsiradusi spraga buvo užpildyta masyviu alografiniu transplantatu, kurį sudarė keturgalvio raumens sausgyslė, girnelė ir girnelės raištis. Komplikacijų ar vietinių recidyvų nebuvo. Paskutinio stebėjimo metu pacientas neturėjo jokio tiesimo sutrikimo, o keturgalvio raumens jėga buvo visiškai atkurta.
    UNASSIGNED: Masyvūs alograftai gali būti patikima alternatyva kelio girnelės ir kelio girnelės tiesiamojo aparato rekonstrukcijai ortopedinėje onkologijoje.
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  • 文章类型: Case Reports
    病人,一位69岁的女性,在接受全肘关节置换术并伴有肱骨假体周围骨折的一年后出现。由于患者的同侧肩严重骨关节炎和显著的肱骨畸形,通过骨水泥同种异体移植-复合连接套将全肘关节成形术与反向肩关节植入物连接。以前的文献表明,使用大型同种异体移植物的上肢抢救手术可成功治疗大型肿瘤或感染源性缺陷,尽管缺乏关于这种治疗对有显著合并症的患者的假体周围骨折是否有效的数据。该患者在术后一年的成功支持使用同种异体移植-复合重建,然后连接到反向肩关节植入物,作为在某些情况下修复假体周围骨折的抢救治疗。例如多个相邻的植入物,骨畸形,和严重的骨关节炎。
    The patient, a 69-year-old female, presented one year after receiving a total elbow arthroplasty with a nonunion periprosthetic fracture of the humerus. Due to the patient\'s severe osteoarthritis of the ipsilateral shoulder and significant humeral deformity, a procedure linking the total elbow arthroplasty to the reverse shoulder implant via a cemented allograft-composite linkage sleeve was performed. Previous literature suggests upper extremity salvage surgery using large-scale allografts is successful in treating large tumor or infection-derived defects, though data is lacking as to whether this treatment is effective in periprosthetic fractures in patients with significant comorbidities. This patient\'s success in the postoperative year supports the use of allograft-composite reconstruction followed by linkage to a reverse shoulder implant as a salvage treatment for periprosthetic fractures under certain conditions, such as multiple adjacent implants, bone deformity, and severe osteoarthritis.
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  • 文章类型: Case Reports
    动脉瘤性骨囊肿(ABC)是骨骼系统的良性溶解性骨肿瘤,但未知来源的局部破坏性病变。它通常发生在儿童时期,通常涉及长骨的干phy端区域;因此,它在跟骨中的定位仍然很少见;在我们的案例中,它的非典型表现使其引人注目。
    方法:我们描述了一个患有慢性足跟痛的年轻患者,临床检查发现触诊时肿胀和疼痛。进行了完整的放射学评估,显示跟骨内有孤立性和扩张性溶骨性病变。治疗包括肿瘤刮治和同种异体移植和骨水泥重建。活检报告与ABC一致。术后18个月的随访具有良好的放射临床演变和无复发。
    ABCs是良性囊性扩张性肿瘤,具有反应性,局部破坏性和充满血液的,它们在跟骨发生的报告病例仅占总报告病例的1.6%。Talalgia是与肿胀相关的最常见体征。MRI上的液位图像是这些病变的病理标志,但金标准诊断仍然是组织学。他们的治疗是基于刮治-通过移植填充。
    结论:刮治联合移植使效果良好,并提高了生活质量。
    UNASSIGNED: Aneurysmal bone cyst (ABC) is a benign lytic bone tumor of the skeletal system but locally destructive lesion of unknown origin. It often occurs in childhood and usually involves the metaphyseal region of long bones; thus, its localisation in the calcaneum remains rare; its atypical presentation in our case makes it remarkable.
    METHODS: We describe a case of a young patient who suffered from chronic heel pain, in whom the clinical examination finds swelling and pain on palpation. A complete radiological assessment was carried out, which revealed a solitary and expansive osteolytic lesion within the calcaneus. Treatment included tumor curettage and reconstruction with allograft and cement. The biopsy report was consistent with an ABC. The postoperative follow-up at 18 months was marked by a good radio-clinical evolution and no recurrence.
    UNASSIGNED: ABCs are benign cystic expansive tumors that are reactive, locally destructive and blood-filled, their occurrence in the calcaneus has been reported in only 1.6 % of total reported cases. Talalgia is the most frequent sign associated with swelling. Liquid-liquid level images on MRI is a pathognomonic sign of these lesions but the gold standard diagnosis remains histology. Their treatment is based on curettage - filling by grafting.
    CONCLUSIONS: Curettage combined graft makes results butter and improves the quality of life.
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  • 文章类型: Journal Article
    近年来报道了令人满意的半月板同种异体移植(MAT)的临床结果。然而,目前尚不清楚MAT联合截骨术的临床结局是否低于孤立MAT.
    比较接受孤立内侧MAT的患者与接受内侧MAT联合胫骨高位截骨术(HTO)的患者的生存率和临床结局。
    队列研究;证据水平,3.
    共有55名患者使用软组织技术和HTO(平均年龄,41.3±10.4岁;9名女性);在人口统计学上进行模糊病例对照匹配后,还包括55名接受孤立内侧MAT的对照。生存分析使用Kaplan-Meier方法进行手术失败,临床失败(Lysholm评分,<65),并作为端点重新操作。术前和最后随访时收集主观临床评分。
    平均随访时间为5.4年,长达8年。在最后一次随访中,所有结果均显着改善(P<.001)。术前和末次随访时,MAT组和MAT+HTO组之间无差异(P>0.05)。在最后的后续行动中,MAT+HTO患者的55人中有8人(14.5%)和MAT患者的55人中有9人(16.4%)的Lysholm评分<65(P=.885)。总的来说,90%的患者宣布他们将重复手术,而不管联合手术。110例患者中有6例(5.5%)出现手术失败:MAT+HTO组55例中有5例(9.1%),MAT组55例中有1例(1.8%)(P=0.093)。110例患者中有19例(17.3%)临床失败:MATHTO组55例中有11例(20%),MAT组55例中有8例(14.5%)(P=0.447)。在MAT+HTO组中,手术失败后的存活率显着降低(风险比,5.1;P=.049),而再次手术和临床失败的生存率没有差异(P>.05)。
    接受内侧MAT+HTO的患者在中期随访时表现出与接受孤立内侧MAT的患者相似的临床结果,因此,手术解决的对准不良并不代表内侧MAT的禁忌症。然而,随着时间的推移,对伴随的HTO的需求与较高的故障率相关。
    UNASSIGNED: Satisfactory clinical results of meniscal allograft transplantation (MAT) have been reported in recent years. However, it remains unclear whether the clinical outcomes of MAT when combined with an osteotomy are inferior to those of isolated MAT.
    UNASSIGNED: To compare the survival rates and clinical outcomes of patients who received isolated medial MAT with those of patients undergoing medial MAT combined with high tibial osteotomy (HTO).
    UNASSIGNED: Cohort study; Level of evidence, 3.
    UNASSIGNED: A total of 55 patients underwent arthroscopic medial MAT using the soft tissue technique and HTO (mean age, 41.3 ± 10.4 years; 9 female); after fuzzy case-control matching on demographics, 55 controls who underwent isolated medial MAT were also included. Survival analyses were performed using the Kaplan-Meier method with surgical failure, clinical failure (Lysholm score, <65), and reoperation as endpoints. Subjective clinical scores were collected preoperatively and at the final follow-up.
    UNASSIGNED: The mean follow-up time was 5.4 years, up to 8 years. All outcomes significantly improved at the last follow-up (P < .001). No differences were identified between MAT and MAT + HTO groups preoperatively and at the last follow-up (P > .05). At the final follow-up, 8 of 55 (14.5%) of the MAT + HTO patients and 9 of 55 (16.4%) of the MAT patients had a Lysholm score <65 (P = .885). Overall, 90% of the patients declared they would repeat the surgery regardless of the combined procedure. Surgical failure was identified in 6 of 110 (5.5%) patients: 5 of 55 (9.1%) in the MAT + HTO group and 1 of 55 (1.8%) in the MAT group (P = .093). Clinical failure was identified in 19 of 110 (17.3%) patients: 11 of 55 (20%) in the MAT + HTO group and 8 of 55 (14.5%) in the MAT group (P = .447). A significantly lower survivorship from surgical failure was identified in the MAT + HTO group (hazard ratio, 5.1; P = .049), while no differences in survivorship from reoperation and clinical failure were identified (P > .05).
    UNASSIGNED: Patients undergoing medial MAT + HTO showed similar clinical results to patients undergoing isolated medial MAT at midterm follow-up, and thus a surgically addressed malalignment does not represent a contraindication for medial MAT. However, the need for a concomitant HTO is associated with a slightly higher failure rate over time.
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  • 文章类型: Case Reports
    本文报道了同一患者肩袖滑膜(RCT)有无同种异体移植物的病理学比较,并评估了上囊重建(SCR)后的同种异体移植物重塑。一名49岁的男子接受了筋膜同种异体移植的SCR治疗,以进行不可修复的RCT。术后两年,患者接受关节镜下肩袖修补术进行左侧RCT和关节镜下清创术以减轻右肩疼痛.此外,在筋膜的同种异体移植物中证实了血运重建。总之,同种异体移植物被认为是高度安全的,预计在SCR后移植。
    This paper reports a pathological comparison between the synovium of the shoulder with rotator cuff tears (RCTs) with or without an allograft in the same patient and assesses allograft remodeling after superior capsular reconstruction (SCR). A 49-year-old man underwent SCR with a fascia lata allograft for irreparable RCTs. Two years postoperatively, the patient underwent arthroscopic rotator cuff repair for left RCTs and arthroscopic debridement to alleviate right shoulder pain. Additionally, revascularization was confirmed in the allograft of the fascia lata. In conclusion, allografts are considered highly safe and expected to be engrafted after SCR.
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  • 文章类型: Case Reports
    骨巨细胞瘤(GCT)是一种罕见的肿瘤,通常表现为长骨骨骨区域的溶解性病变,通常伴有疼痛,肿胀,限制移动。
    骨巨细胞瘤(GCT)是一种罕见的肿瘤,影响个体生命的第三个和第四个十年。临床上,它通常表现为骨骼骨phy区的溶解性病变,尤其是股骨远端和胫骨近端。放射学上,GCT表现为epi骨区域的明显溶解性病变。组织病理学,GCT由单核细胞组成,巨噬细胞,多核巨细胞,提示破骨细胞间质瘤。一名37岁男子左手腕疼痛,肿胀,限制运动持续一年,在过去的7个月中恶化。影像学评估显示,桡骨远端骨量涉及ri腕关节。活检证实GCT延伸至外周肌肉。PET/CT扫描显示病灶无转移。组织病理学,GCT显示多核巨细胞,梭形细胞,动脉瘤样骨囊肿样区伴凝固性坏死。手术切除包括整体切除和使用非血管化桡骨移植重建。术后,患者在一年的随访中没有出现并发症,建议成功的干预。
    UNASSIGNED: Giant cell tumor of bone (GCT) is a rare neoplasm which often presents as a lytic lesion in the epiphyseal region of long bones and which are usually accompanied by pain, swelling, and restricted movement.
    UNASSIGNED: Giant cell tumor of bone (GCT) is a rare neoplasm that affects individuals in their third and fourth decades of life. Clinically, it often presents as a lytic lesion in the epiphyseal region of bones, notably the distal femur and proximal tibia. Radiologically, GCT appears as a distinct lytic lesion in the epiphyseal region. Histopathologically, GCTs are composed of mononuclear cells, macrophages, and multinuclear giant cells, indicative of osteoclastogenic stromal tumors. A 37-year-old man presented with left wrist pain, swelling, and restricted movement persisting for a year, worsening over the last 7 months. Radiographic assessments revealed a distal radius bone mass involving the radiocarpal joint. Biopsy confirmed a GCT with extension into peripheral muscle. PET/CT scan showed localized pathology without metastasis. Histopathologically, GCT exhibited multinucleated giant cells, spindle cells, and aneurysmal bone cyst-like regions with coagulation necrosis. Surgical resection involved en-bloc removal and reconstruction with a non-vascularized radius bone graft. Postoperatively, the patient showed no complications at the one-year follow-up, suggesting successful intervention.
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