PDF(Pubmed)
Abstract：
UNASSIGNED: Giant cell tumor of bone (GCT) is a rare neoplasm which often presents as a lytic lesion in the epiphyseal region of long bones and which are usually accompanied by pain, swelling, and restricted movement.
UNASSIGNED: Giant cell tumor of bone (GCT) is a rare neoplasm that affects individuals in their third and fourth decades of life. Clinically, it often presents as a lytic lesion in the epiphyseal region of bones, notably the distal femur and proximal tibia. Radiologically, GCT appears as a distinct lytic lesion in the epiphyseal region. Histopathologically, GCTs are composed of mononuclear cells, macrophages, and multinuclear giant cells, indicative of osteoclastogenic stromal tumors. A 37-year-old man presented with left wrist pain, swelling, and restricted movement persisting for a year, worsening over the last 7 months. Radiographic assessments revealed a distal radius bone mass involving the radiocarpal joint. Biopsy confirmed a GCT with extension into peripheral muscle. PET/CT scan showed localized pathology without metastasis. Histopathologically, GCT exhibited multinucleated giant cells, spindle cells, and aneurysmal bone cyst-like regions with coagulation necrosis. Surgical resection involved en-bloc removal and reconstruction with a non-vascularized radius bone graft. Postoperatively, the patient showed no complications at the one-year follow-up, suggesting successful intervention.
UNASSIGNED: Giant cell tumor of bone (GCT) is a rare neoplasm that affects individuals in their third and fourth decades of life. Clinically, it often presents as a lytic lesion in the epiphyseal region of bones, notably the distal femur and proximal tibia. Radiologically, GCT appears as a distinct lytic lesion in the epiphyseal region. Histopathologically, GCTs are composed of mononuclear cells, macrophages, and multinuclear giant cells, indicative of osteoclastogenic stromal tumors. A 37-year-old man presented with left wrist pain, swelling, and restricted movement persisting for a year, worsening over the last 7 months. Radiographic assessments revealed a distal radius bone mass involving the radiocarpal joint. Biopsy confirmed a GCT with extension into peripheral muscle. PET/CT scan showed localized pathology without metastasis. Histopathologically, GCT exhibited multinucleated giant cells, spindle cells, and aneurysmal bone cyst-like regions with coagulation necrosis. Surgical resection involved en-bloc removal and reconstruction with a non-vascularized radius bone graft. Postoperatively, the patient showed no complications at the one-year follow-up, suggesting successful intervention.
摘要：
■骨巨细胞瘤（GCT）是一种罕见的肿瘤，通常表现为长骨骨骨区域的溶解性病变，通常伴有疼痛，肿胀,限制移动。
骨巨细胞瘤（GCT）是一种罕见的肿瘤，影响个体生命的第三个和第四个十年。临床上,它通常表现为骨骼骨phy区的溶解性病变，尤其是股骨远端和胫骨近端。放射学上,GCT表现为epi骨区域的明显溶解性病变。组织病理学,GCT由单核细胞组成，巨噬细胞，多核巨细胞，提示破骨细胞间质瘤。一名37岁男子左手腕疼痛,肿胀,限制运动持续一年，在过去的7个月中恶化。影像学评估显示，桡骨远端骨量涉及ri腕关节。活检证实GCT延伸至外周肌肉。PET/CT扫描显示病灶无转移。组织病理学,GCT显示多核巨细胞，梭形细胞,动脉瘤样骨囊肿样区伴凝固性坏死。手术切除包括整体切除和使用非血管化桡骨移植重建。术后,患者在一年的随访中没有出现并发症，建议成功的干预。
骨巨细胞瘤（GCT）是一种罕见的肿瘤，影响个体生命的第三个和第四个十年。临床上,它通常表现为骨骼骨phy区的溶解性病变，尤其是股骨远端和胫骨近端。放射学上,GCT表现为epi骨区域的明显溶解性病变。组织病理学,GCT由单核细胞组成，巨噬细胞，多核巨细胞，提示破骨细胞间质瘤。一名37岁男子左手腕疼痛,肿胀,限制运动持续一年，在过去的7个月中恶化。影像学评估显示，桡骨远端骨量涉及ri腕关节。活检证实GCT延伸至外周肌肉。PET/CT扫描显示病灶无转移。组织病理学,GCT显示多核巨细胞，梭形细胞,动脉瘤样骨囊肿样区伴凝固性坏死。手术切除包括整体切除和使用非血管化桡骨移植重建。术后,患者在一年的随访中没有出现并发症，建议成功的干预。
