■弓形虫是一种寄生虫,广泛分布于全球各地,可引起脑部炎症,特别是在免疫抑制患者中,例如被诊断患有人类免疫缺陷病毒(HIV)的患者。本文就阿奇霉素和乙胺嘧啶联合治疗HIV合并脑弓形体病的疗效进行综述。
■本综述的研究范围仅限于1992年至2022年,主要是随机研究。在线科学期刊数据库上提供的对照临床试验。作者筛选了符合条件的记录进行审查,剔除不符合纳入和排除标准的患者.通过用于随机试验的Cochrane偏倚风险工具分析提取数据的偏倚风险。
■广泛搜索主要的在线数据库,例如PubMed,Medline,谷歌学者,和Cochrane使用关键字,限制字段,和布尔运算符产生了3130篇文章。在彻底筛选搜索结果之后,本综述包括两项研究.综述中的研究结果表明,阿奇霉素和乙胺嘧啶的联合治疗对脑弓形体病有利。然而,净疗效低于标准治疗方案(乙胺嘧啶和磺胺嘧啶).
■阿奇霉素和乙胺嘧啶的联合治疗比维持治疗脑弓形体病的标准治疗方案效果差;因此,必须谨慎使用这些药物治疗这种适应症。
UNASSIGNED: Toxoplasma gondii is a parasite that is widely distributed around the globe and can cause brain inflammation, particularly in immunosuppressed patients such as those diagnosed with human immunodeficiency virus (HIV). This paper reviews the efficacy of azithromycin and pyrimethamine combination therapy for cerebral toxoplasmosis in patients with HIV.
UNASSIGNED: The scope of the studies included in this
review was limited from 1992 to 2022, with studies primarily being randomized, controlled clinical trials available on online scientific journal databases. The authors screened eligible records for
review, removing those that did not fit the inclusion and exclusion criteria. The risk of bias of the extracted data was analyzed through the Cochrane risk-of-bias tool for randomized trials.
UNASSIGNED: A broad search of major online databases such as PubMed, Medline, Google Scholar, and Cochrane using keywords, limit fields, and Boolean operators yielded 3,130 articles. After thoroughly screening the search results, two studies were included in this
review. Results from the studies included in the
review demonstrate that the combination therapy of azithromycin and pyrimethamine is favorable for cerebral toxoplasmosis. However, the net response is less effective than the standard treatment regimen (pyrimethamine and sulfadiazine).
UNASSIGNED: The combination therapy of azithromycin and pyrimethamine is less effective than the standard treatment regimen for maintenance therapy for cerebral toxoplasmosis; thus, administering these medications for this indication must be met with caution.