阿立哌唑对精神分裂症的阳性和阴性症状都是有效的治疗方法,也常用作情绪稳定剂。与其他抗精神病药相比,它具有更好的耐受性。然而,有报告说患者经历了问题赌博,性欲亢进,强迫症状,以及由于阿立哌唑给药和/或剂量增加而产生的其他冲动和/或强迫行为。我们旨在对在这方面发表的病例报告进行系统审查。在十个科学搜索引擎中筛选了6000多个标题和摘要后,我们发现了35条相关记录,包括59例。大多数病例(n=42,71.18%)为男性,平均年龄为33.83岁(±13.40),阿立哌唑的平均日剂量为11.63mg(±6.94)。我们的审查结果表明,阿立哌唑最常见的冲动不良反应是赌博,其次是性欲过高,强迫症状/障碍,吃问题,毛滴虫病,问题购物,和窃贼。这些症状在这些地区以前有问题的患者和没有问题的患者都经历过。在大多数情况下,症状在阿立哌唑开始给药后30天内出现,并在停药和/或剂量减少后30天内停止.临床医生应该意识到冲动的不良影响,监视他们,并教育病人和家人。
Aripiprazole is an efficacious treatment for both the positive and negative symptoms of schizophrenia and is also commonly used as a mood stabilizer. It is associated with better tolerability compared with other antipsychotics. However, there are
reports of patients who experience problem gambling, hypersexuality, obsessive-compulsive symptoms, and other impulsive and/or compulsive behaviors as a result of aripiprazole administration and/or dosage increase. We aimed to do a systematic review of
case reports published in this regard. After screening more than 6000 titles and abstracts in ten scientific search engines, we found 35 related records comprising 59 cases. The majority of cases (n = 42, 71.18%) were male, the mean age was 33.83 years (± 13.40), and the average daily dose of aripiprazole was 11.63 mg (± 6.94). The results of our review showed that the most frequently published impulsivity adverse effect of aripiprazole is gambling, followed by hypersexuality, obsessive-compulsive symptoms/disorder, problem eating, trichotillomania, problem shopping, and kleptomania. These symptoms were experienced both by patients who had previous problems in these areas and those who did not. In the majority of cases, the symptoms appeared within 30 days after aripiprazole administration started and ceased within 30 days of its discontinuation and/or dose decrease. Clinicians should be aware of impulsivity adverse effects, monitor them, and educate both patients and the family about them.