PDF(Pubmed)
Abstract：
BACKGROUND: Dyclonine hydrochloride mucilage is a topical anaesthetic formulated for mucosal surfaces. It is employed frequently for topical anaesthesia of the pharynx prior to endoscopic examinations such as electronic gastroscopy, and few adverse reactions have been reported. This article describes a patient who experienced a transient but severe disturbance of consciousness following oral dyclonine hydrochloride mucilage administration.
METHODS: A 75-year-old female presenting with gastrointestinal bleeding was examined by electronic gastroscopy. Six minutes after oral dyclonine hydrochloride mucilage administration, the patient entered a comatose-like state accompanied by loss of limb muscle tone and profuse perspiration. This response was not accompanied by changes in cardiac rhythm, blood pressure, or respiration rate, suggesting an effect on higher brain centres. After ten minutes, the patient\'s symptoms were alleviated.
CONCLUSIONS: We suggest that sites of dyclonine hydrochloride mucilage use be equipped with appropriate rescue devices for these rare events.
METHODS: A 75-year-old female presenting with gastrointestinal bleeding was examined by electronic gastroscopy. Six minutes after oral dyclonine hydrochloride mucilage administration, the patient entered a comatose-like state accompanied by loss of limb muscle tone and profuse perspiration. This response was not accompanied by changes in cardiac rhythm, blood pressure, or respiration rate, suggesting an effect on higher brain centres. After ten minutes, the patient\'s symptoms were alleviated.
CONCLUSIONS: We suggest that sites of dyclonine hydrochloride mucilage use be equipped with appropriate rescue devices for these rare events.
摘要：
背景：盐酸达克罗宁胶浆是一种为粘膜表面配制的局部麻醉剂。在内窥镜检查如电子胃镜检查之前，它经常用于咽部的局部麻醉，很少有不良反应的报道。本文描述了口服盐酸达克罗宁胶浆后出现短暂但严重的意识障碍的患者。
方法：采用电子胃镜检查一名75岁女性出现消化道出血。口服盐酸达克罗宁胶浆后六分钟，患者进入昏迷样状态，伴有肢体肌张力丧失和大量出汗。这种反应没有伴随着心律的变化，血压,或呼吸速率，表明对更高的大脑中心有影响。十分钟后,患者的症状得到缓解。
结论：我们建议使用盐酸达克罗宁胶浆的部位应配备适当的救援装置，以应对这些罕见事件。
方法：采用电子胃镜检查一名75岁女性出现消化道出血。口服盐酸达克罗宁胶浆后六分钟，患者进入昏迷样状态，伴有肢体肌张力丧失和大量出汗。这种反应没有伴随着心律的变化，血压,或呼吸速率，表明对更高的大脑中心有影响。十分钟后,患者的症状得到缓解。
结论：我们建议使用盐酸达克罗宁胶浆的部位应配备适当的救援装置，以应对这些罕见事件。
