背景:食用地中海饮食(MedDiet)对心脏代谢健康和衰老具有有益作用。
目的:本系统综述旨在严格研究MedDiet对健康或超重2型糖尿病或心血管疾病患者糖化标志物的影响。
方法:MEDLINE,EMBASE,WebofScience,搜索了Cochrane图书馆,使用术语“地中海饮食”和“糖化终产物”,高级\"。
方法:3项随机和3项非随机临床试验,包含2935名体重正常或超重的成年人和老年人的数据,包括在内。所有提取的数据都经过汇编,比较,并批判性地分析。
方法:大多数研究的作者证明了晚期糖基化终产物(AGEs)的血清浓度降低,如εN-羧甲基赖氨酸和甲基乙二醛,和皮肤自发荧光水平在坚持至少4周后的MedDiet。MedDiet还对AGEs受体的基因表达产生积极影响,作为RAGE和AGER1,以及参与解毒的酶(乙二醛酶I)。没有证据表明短期依从性会影响糖化标志物。
结论:糖化标志物对MedDiet的反应有所改善。可能涉及的机制可能与饮食中的低AGE和精制糖含量有关,以及它的高单不饱和脂肪酸,酚类化合物,和膳食纤维含量。
背景:PROSPERO注册号。CRD42021284006.
BACKGROUND: Consumption of the Mediterranean diet (MedDiet) has beneficial effects on cardiometabolic health and aging.
OBJECTIVE: This systematic
review aimed to critically investigate the effect of the MedDiet on glycation markers in healthy or overweight individuals with type 2 diabetes or cardiovascular disease.
METHODS: MEDLINE, EMBASE, Web of Science, and the Cochrane Library were searched, using the terms \"Mediterranean diet\" AND \"glycation end products, advanced\".
METHODS: Three randomized and 3 nonrandomized clinical trials, containing data on 2935 adult and elderly individuals with normal weight or overweight, were included. All extracted data were compiled, compared, and critically analyzed.
METHODS: The authors of most of the studies demonstrated a reduction in serum concentrations of advanced glycation end products (AGEs), such as εN-carboxymethyllysine and methylglyoxal, and in skin autofluorescence levels after at least 4 weeks of adherence to the MedDiet. The MedDiet also led to positive effects on gene expression of receptors for AGEs, as RAGE and AGER1, and an enzyme involved in detoxification (glyoxalase I). There is no evidence that short-term adherence affects glycation markers.
CONCLUSIONS: Glycation markers improved in response to the MedDiet. The possible mechanisms involved may be related to the low AGE and refined sugars content of the diet, as well as its high monounsaturated fatty acid, phenolic compound, and dietary fiber contents.
BACKGROUND: PROSPERO registration no. CRD42021284006.