背景:肌肉结核(TB)的早期诊断而不同时存在活动性骨骼受累通常具有挑战性,因为该疾病非常罕见,其临床表现是非特异性和误导性的。为了提高认识,强调肌肉结核病的早期诊断,我们介绍了一例系统性红斑狼疮(SLE)女性多发性结核性肌肉脓肿,但没有肺结核(PTB),为了提高对肌肉结核病的认识和强调早期检测的必要性。
方法:一名44岁女性,有6年的SLE病史,长期使用甲基强的松龙治疗5个月,主诉躯干和四肢出现红斑,伴随着水肿和肌痛两个月,发烧一个月。患者首次误诊为SLE重叠皮肌炎。然而,使用宏基因组下一代测序(mNGS),超声引导下的肌肉脓肿引流显示,抗酸染色阳性,结核分枝杆菌脱氧核糖核酸片段阳性.患者在标准抗结核药物治疗后治愈并出院,局部穿刺引流,和玻璃体内注射链霉素.文献检索发现,从1999年到2023年,只有19例发生在四肢的结核性肌肉脓肿。
结论:肺外结核以肌肉受累为主是罕见的,没有具体的临床表现。由于肌肉酶水平高,肌肉结核可能会被诊断为皮肌炎,延迟诊断和治疗。mNGS技术有助于肌肉结核病的早期和快速诊断。在传统抗结核治疗的基础上,超声引导经皮穿刺引流术和链霉素腔内注射治疗结核性肌肉脓肿操作简单,安全有效,值得临床推广应用。
BACKGROUND: Early diagnosis of muscular tuberculosis (TB) without coexistent active skeletal involvement is often challenging because the disease is very rare and its clinical manifestation is nonspecific and misleading. To raise the awareness and emphasize early diagnosis of muscular TB, we present a case of multiple tuberculous muscle abscesses in a systemic lupus erythematosus (SLE) female, but without pulmonary tuberculosis (PTB), in order to increase awareness of and stress the need of early detection of muscular TB.
METHODS: A 44-year-old woman with a 6-year history of SLE who had been treated with methylprednisolone for a long time complained of erythema on her trunk and extremities for five months, along with edema and myalgia for two months, and fever for one month. The patient was first misdiagnosed as SLE overlap dermatomyositis. However, an ultrasound-guided drainage of muscle abscesses revealed positive acid-fast staining combined with positive deoxyribonucleic acid fragment of Mycobacterium tuberculosis using metagenomic next-generation sequencing (mNGS). The patient was cured and released following standard anti-tuberculosis medication, local puncture drainage, and an intravitreal injection of streptomycin. Literature search found only 19 cases of tuberculous muscle abscesses occurring in the extremities reported from 1999 to 2023.
CONCLUSIONS: Extrapulmonary TB with predominantly muscle involvement is rare and with no specific clinical presentation. Muscular tuberculosis may be disdiagnosed for dermatomyositis due to the high muscle enzyme levels, delaying diagnosis and treatment. mNGS technology is helpful in the early and rapid diagnosis of muscular TB. On the basis of traditional anti-tuberculosis treatment, an ultrasound-guided percutaneous puncture drainage and intracavitary injection of streptomycin for the treatment of tuberculous muscle
abscess is easy to operate, safe and effective, which is worthy of clinical popularization and application.