UNASSIGNED: Chronic axial low back pain due to zygapophysial joint arthropathy is best diagnosed via lumbar medial branch block (MBB). However, the paradigm by which MBB is used to select patients for lumbar radiofrequency neurotomy (RFN) is contested. Dual diagnostic lumbar MBB with a minimum of ≥80% pain relief to diagnose lumbar zygapophysial joint pain are accepted by some Medicare Local Coverage Determination (LCD) as the method for selecting patients for RFN for the management of lumbar zygapophysial joint pain. However, some argue that dual diagnostic MBB and the ≥80% pain relief threshold lack utility in clinical practice, given that those that progress from MBB1 to MBB2 will then flow from MBB2 to RFN without fail.
UNASSIGNED: Pragmatic retrospective clinical audit.
UNASSIGNED: Does clinical practice of dual diagnostic lumbar MBBs and an ≥80% pain improvement diagnostic threshold reduce patient eligibility for RFN after both MBB1 and MBB2?
UNASSIGNED: Using dual diagnostic lumbar MBBs and an ≥80% pain improvement diagnostic threshold, 90/167 (54%, 95% CI 46-61%) patients successfully progressed from MBB1 to MBB2. Of those 90 patients, 66 patients (73%, 95% CI 64-82%) successfully progressed from MBB2 to RFN. Both MBB1 and MBB2 impacted the eligibility of the progression of 77/167 (46%, 95% CI 39-54%) patients and 24/90 patients (27%, 95% CI 18-36%), respectively. An additional sub-cohort analysis which included all the patients from the ≥80% pain relief cohort, and those who progressed at the discretion of the providers with 50-79% relief revealed that 124/167 patients (74%, 95% CI 68-81%) successfully progressed from MBB1 to MBB2. Of those 124 patients, 99 patients (80%, 95% CI 73-87%) progressed from MBB2 to RFN. In this laxer criteria cohort, MBB1 and MBB2 impacted the eligibility of the progression of 43/167 patients (26%, 95% CI 19-32%) and 25/124 patients (20%, 95% CI 13-27%), respectively.
UNASSIGNED: MBB1 and MBB2 both filtered patients from progression to lumbar RFN using dual MBBs with an ≥80% pain relief criteria. It also held true when using a more relaxed pain relief selection criterion as well. Dual MBB\'s and ≥80% pain improvement criteria as a selection paradigm led to half as many lumbar RFNs being performed when compared to a single MBB and ≥80% pain improvement criteria. In theory, a more rigid selection paradigm treats less patients but exposes fewer to unnecessary RFNs while a laxer selection paradigm treats more patients but exposes more to unnecessary RFNs.

UNASSIGNED: Evidence characterizing a starting angle of radiofrequency (RF) cannula insertion during radiofrequency neurotomy is lacking. Using computerized tomography (CT), this retrospective observational study attempts to establish a starting angle for RF cannula placement parallel to the transverse process (TP) at the junction of the superior articular process (SAP) near the targeted medial branch.
UNASSIGNED: This retrospective observational study utilized lumbar spine CT scans performed on adult cancer patients from January 2016 to May 2021 ​at a single center. No significant lumbar pathology was present on the included CT studies. For each patient, medial branches were assumed to lie at the junction of the right and left TP and SAP at each lumbar level. The angle of insertion from each segment\'s \"squared\" superior end plate needed for RF cannula placement parallel to the surface of the TP next to the SAP was calculated.
UNASSIGNED: Images obtained from fifty patients were analyzed. Mean angle of insertion for L1 was 20.15 ​± ​1.82°, L2 was 20.95 ​± ​2.07°, L3 was 25.54 ​± ​1.76°, L4 was 31.01 ​± ​1.83°, and L5 was 40.74 ​± ​1.86°.
UNASSIGNED: This study demonstrates variations in inserting angle for RF cannula placement parallel to the surface of the transverse process at each lumbar level. To our knowledge, there are no studies in the current literature that have described an entry angle for RF cannula positioning parallel to lumbar medial branches using CT images.

BACKGROUND: Posterolateral decompression and fusion with internal fixation is a commonly used surgical approach for treating degenerative lumbar spinal stenosis (DLSS). This study aims to evaluate the impact of preserving a portion of the unilateral facet joint during decompression on surgical outcomes and long-term recovery in patients.
METHODS: This study analyzed 73 patients with DLSS accompanied by bilateral lower limb neurological symptoms who underwent single-level L4/5 posterolateral decompression and fusion surgery from January 2022 to March 2023. Patients were categorized into two groups based on the type of surgery received: Group A comprised 31 patients who underwent neural decompression without facet joint preservation, while Group B consisted of 42 patients who underwent neural decompression with preservation of partial facet joints on one side. Regular follow-up evaluations were conducted, including clinical and radiological assessments immediately postoperatively, and at 3 and 12 months thereafter. Key patient information was documented through retrospective chart reviews.
RESULTS: Most patients in both groups experienced favorable surgical outcomes. However, four cases encountered complications. Notably, during follow-up, Group B demonstrated superior 1-year postoperative interbody fusion outcomes (P < 0.05), along with a trend towards less interbody cage subsidence and slower postoperative intervertebral disc height loss. Additionally, Group B showed significantly reduced postoperative hospital stay (P < 0.05).
CONCLUSIONS: Under strict adherence to surgical indications, the posterior lateral lumbar fusion surgery, which preserves partial facet joint unilaterally during neural decompression, can offer greater benefits to patients.

Chronic low-back pain (LBP) is a leading cause of disability worldwide, and traditional pharmacotherapy fails to provide relief for many individuals with this condition. An estimated 15% of chronic LBP cases can be attributed to the facet joint. High-intensity focused ultrasound (HIFU) is a recent technology that enables noninvasive thermal ablation of tissue and has shown efficacy in treating tumors, neuropathic pain, and painful bone metastases. In this systematic review, the authors summarize the literature on lumbar facet joint-mediated pain treated with HIFU and report the effectiveness of HIFU on pain outcomes.
All full-text English-language articles describing the use of focused ultrasound for facet joint pain were screened using the PubMed/MEDLINE, Embase, Cochrane Library, Scopus, and Web of Science databases. Clinical studies were assessed for bias using the methodological index for nonrandomized studies.
Eleven studies (6 preclinical and 5 clinical) reporting on 50 patients were included. Eight of these studies (73%) used MR-guided focused ultrasound ablation and 3 used fluoroscopy. The medial branch nerve and posterior facet joint capsule were the most common targets for focused ablation. Although the energy used ranged from 300 to 2000 J, clinical studies predominantly operated in the range of 1000 to 1500 J. Pain reduction was seen in all clinical studies, with multiple-point reductions from average baseline pain scores in 6-12 months. No study reported any adverse events or complications.
HIFU can be effective in treating chronic low-back pain arising from the facet joint. Further clinical studies should explore the long-term effects of HIFU and monitor changes in pain reduction over time.

BACKGROUND: Facet joint osteoarthritis (FJOA) is a prevalent condition contributing to low back pain, particularly in the elderly population. This study aimed to investigate the potential role of Cytokine Receptor-like Factor 1 (CRLF1) in FJOA pathogenesis and its therapeutic implications.
METHODS: Bioinformatics analysis was utilized to identify CRLF1 as the target gene, followed by quantification of CRLF1 expression levels and joint degeneration degree using immunohistochemistry (IHC). In primary chondrocytes, the inhibition of CRLF1 expression by siRNA was performed, and Western blot analysis was conducted to evaluate the involvement of the extracellular matrix and MAPK/ERK signaling pathway. Flow cytometry was employed to assess the apoptosis rate of chondrocytes, while immunofluorescence (IF) was utilized to evaluate the localization of CRLF1, cleaved-caspase3, MMP13, COL2A1, and ERK.
RESULTS: The expression of CRLF1 was found to be significantly elevated in FJOA tissues compared to normal tissues. Through the use of loss-of-function assays, it was determined that CRLF1 not only enhanced the rate of apoptosis in chondrocytes, but also facilitated the degradation of the extracellular matrix in vitro. Furthermore, CRLF1 was found to activate the ERK1/2 pathways. The pro-arthritic effects elicited by CRLF1 were mitigated by treatment with the MEK inhibitor U0126 in chondrocytes.
CONCLUSIONS: These results suggest that CRLF1 enhances chondrocytes apoptosis and extracellular matrix degration in FJOA and thus may therefore be a potential therapeutic target for FJOA.

BACKGROUND Cervical spondylosis (CS) is a degenerative disease of the cervical spine characterized by persistent neck pain. Cervical facet joint mobilization (CM) and the osteopathic muscle energy technique (MET) are effective manual procedures for the treatment of neck pain. In this study, we compared the efficacy of the MET and CM techniques on pain, disability, and proprioception in 76 patients with CS. MATERIAL AND METHODS A total of 96 participants with a diagnosis of CS were randomized into an electro-thermal therapy (ET) group (control group, n=32), ET+MET group (experiment I, n=32), and ET+CM group (experiment II, n=32). All patients received 3 treatment sessions per week for 4 consecutive weeks. Pain intensity, functional disability and cervical position sense were measured using the visual analog scale (VAS), Copenhagen Neck Functional Disability Scale (CNFDS), and cervical range of motion (CROM) device. RESULTS The study was completed by 76 participants. VAS and CNFDS scores decreased significantly after treatment in all 3 groups (P<0.001); however, there was no significant difference between the groups (P>0.05). Between-group analysis showed a significant difference in extension joint position error in favor of MET (P<0.001), while there was no significant difference between the groups in other movement directions (P>0.05). CONCLUSIONS MET and CM have similar effects on improving pain and disability in individuals with CS and chronic neck pain. However, the results of this study show that MET combined with ET is a more effective method for improving cervical position sense.

Modeling the lumbar facet capsular ligament\'s (FCL) mechanical behavior under various physiological motions has often been a challenge due to limited knowledge about the on-joint in situ ligament state arising from attachment to the bone or other internal loads. Building on prior work, this study presents an enhanced computational model of the lumbar facet capsular ligament by incorporating residual strain and joint pressurization strain, factors neglected in prior models. Further, the model can predict strain and stress distribution across the ligament under various spinal motions, highlighting the influence of the ligament\'s attachment to the bone, internal synovial fluid pressurization, and distribution of collagen fiber alignment on the overall mechanical response of the ligament. Joint space inflation was found to influence the total observed stress and strain fields, both at rest and during motion. A significant portion of the ligament was found to be in tension, even in the absence of external load. Additionally, the model\'s ability to account for residual strain offers a more realistic portrayal of the collagen fibers and elastin matrix\'s role in ligament mechanics. We conclude that (1) computational models of the lumbar facet capsular ligament should not assume that the ligament is unloaded when the joint is in its neutral position, and (2) the ligament is nearly always in tension, which may be important in terms of its long-term growth and remodeling.

Aim: Traditional radiofrequency ablation (TRFA) effectively treats facet joint-related pain, while water-cooled radiofrequency ablation (CRFA) may offer benefits like larger lesions and easier nerve access. Our goal is to assess the effectiveness of TRFA and CRFA for facet joint-related pain.Materials & methods: This retrospective study included an evaluation of 346 RFA interventions performed on 190 patients suffering from long-term low-back pain. The primary outcome was defined as a decrease of ≥50% of the mean numeric rating scale.Results: The primary outcome was achieved at the first follow-up (FU) for both TRFA and CRFA, with pain relief of 55.2 and 60.5%, respectively. At the second FU, the primary outcome was achieved only in the CRFA group (54.1%), although the TRFA group also showed a good improvement (48.6%). In both groups, pain relief was under 50% during the third FU.Conclusion: Our study indicates that both CRFA and TRFA modalities are effective and safe treatments.
What is this article about? In this study, the effectiveness of two different techniques of facet radiofrequency neurotomy (TRFA and CRFA) is compared. The study involved patients with facet joint-related back pain who did not improve with regular treatments but showed positive results with diagnostic blocks. The pain levels are recorded before and after treatment using a numeric rating scale at various times. The main goal was to see if pain decreased by 50% or more after the treatment. Second, the duration of time until patients need another treatment is investigated.What were the results? Both TRFA and CRFA reduced pain significantly in the first 4–8 weeks. TRFA patients had a 55.2% pain reduction, and CRFA patients had a 60.5% reduction. By 2–6 months, only the CRFA group maintained a 54.1% reduction, while the TRFA group had a 48.6% reduction. By 6–12 months, pain relief in both groups was found below 50%. Out of 81 treatments (44 TRFA and 37 CRFA), many patients needed another procedure within 6–12 months.What do the results of this study mean? Both TRFA and CRFA are effective and safe for treating chronic low back pain from facet joints. Although CRFA has some theoretical advantages over TRFA, the study found no significant difference in the outcomes between the two methods.

BACKGROUND Facet joint septic arthritis (SAFJ) is a rare clinical entity that is extremely challenging to diagnose, often presenting unilaterally and with nonspecific clinical symptoms. However, SAFJ has significant morbidity and mortality, especially with delayed diagnosis. It becomes all the more important for the clinician to recognize that SAFJ can present bilaterally and be associated with direct inoculation, such as in acupuncture. CASE REPORT A 53-year-old woman with chronic alcoholism and well-controlled type 2 diabetes mellitus was initially admitted for progressively worsening atraumatic lower back pain. Initial non-contrast magnetic resonance imaging (MRI) of the lumbar spine revealed bilateral L4-L5 and L5-S1 nonspecific facet joint effusions. Clinical examination was unremarkable. Biochemically, the patient had mildly elevated inflammatory markers. She was treated conservatively with close outpatient follow-up. However, her back pain progressively worsened, with new-onset lower limb weakness and numbness. Repeat MRI showed L4-L5 bilateral facet joint fluid collection with adjacent bony destruction, as well as posterior paraspinal and epidural fluid collections compatible with L4-L5 bilateral SAFJ with paraspinal and epidural abscesses. Urgent surgical drainage and bilateral lateral facet decompression was performed. Intraoperative cultures revealed methicillin-sensitive Staphylococcus aureus as the causative organism. Postoperatively, 6 weeks of intravenous and oral antibiotics were given with good recovery. CONCLUSIONS We describe a case of bilateral SAFJ following acupuncture that was initially missed. With the increasing prevalence of acupuncture treatment for lower back pain, bilateral SAFJ should be a diagnostic consideration. Detailed clinical history is key; this, as well as a high index of suspicion, early evaluation and treatment, are essential to obtain a favorable outcome.

Background and Objectives: The term \"Juxtafacet cyst\" refers to both synovial cysts and ganglion pseudocysts associated with the lumbar facet joint. As conservative treatment for the juxtafacet cyst has a minimal effect, complete excision through surgery is considered the first choice of treatment. In this study, we retrospectively reviewed the clinical outcomes of percutaneous epidural neuroplasty for symptomatic lumbar juxtafacet cysts. Materials and Methods: We conducted a retrospective review of 34 patients with symptomatic juxtafacet cysts who visited a single institute from January 2010 to September 2023. Patients who received conservative treatment for at least 6 weeks but experienced no or insufficient effects were eligible for this study. After neuroplasty, a medical history check and neurological examination were performed during follow-up at 2 weeks, 1 month, 2 months, 3 months, 6 months, and once a year thereafter. Results: The pain improved for all patients to a VAS score of 3 or less immediately after neuroplasty; however, four of those patients (11%) had pain that worsened eventually to the same level as before the procedure and required surgery. The results showed that, regardless of cyst size, in cases with severe stenosis of the spinal canal, the outcome of neuroplasty was poor and often eventually required surgery. The cyst size was not associated with the procedure results. In addition, if the cyst was present at the L4-L5 level, or if diabetes mellitus was present, the likelihood of future surgery was significant (p-value = 0.003). Conclusions: Percutaneous neuroplasty showed a better success rate than other non-surgical treatments. In addition, severe spinal stenosis (Schizas grade C or higher), L4-L5 level, or diabetes mellitus produced a high possibility of surgery due to recurrence.