目的:评估填充有2-甲基丙烯酰氧基乙基磷酰胆碱(MPC)和硅酸盐基复合材料的三维(3D)可印刷树脂的机械和生物学性能,并与市售的3D可印刷树脂进行比较用于最终修复。
方法:制备一组填充有6重量%MPC的可3D打印的杂化树脂(HR)和三种不同组成的硅酸盐基复合材料(硅酸钡与硅酸锆的比率:HR1为1.50:1,HR2为0.67:1,HR3为0.25:1)。在弯曲强度和模量方面,将HR组与市售的未填充的3D打印树脂(CR)进行了比较。断裂韧性,表面粗糙度,维氏硬度,透光率(所有,n=15),细胞毒性,和蛋白质吸附(两者,n=3)。所有数据均采用非参数Kruskal-Wallis和Dunn检验(α=0.05)进行分析。
结果:HR组的弯曲强度明显更高,模数,断裂韧性,硬度值高于CR值(P<0.001)。HR3的表面粗糙度和透光率最高(P≤0.006)。测试的树脂均未显示细胞毒性。HR2和HR3均显示出比CR显著更低的蛋白质吸附。差异约为60%(P≤0.026)。
结论:HR2和HR3均表现出优异的机械性能(弯曲强度,弯曲模量,断裂韧性,和维氏硬度),透光率,和蛋白质驱除活性比CR,对细胞毒性没有影响。
结论:MPC/硅酸盐基复合填充树脂可能是最终修复的合适替代品,鉴于其更高的机械性能和有希望的生物学特性,以防止微生物粘附和随后的生物膜形成,以及它们的非细胞毒性。
OBJECTIVE: To evaluate the mechanical and biological properties of three-dimensionally (3D) printable resins filled with 2-methacryloyloxyethyl phosphorylcholine (MPC) and silicate-based composites and compare with those of a commercially available 3D-printable resin for definitive restorations.
METHODS: A group of 3D-printable hybrid resins (HRs) filled with 6 wt% MPC and three different compositions of silicate-based composites (barium silicate to zirconium silicate ratios: 1.50:1 for HR1, 0.67:1 for HR2, and 0.25:1 for HR3) were prepared. The HR groups were compared with the commercially available unfilled 3D-printable resin (CR) marketed for definitive restorations in terms of flexural strength and modulus, fracture toughness, surface roughness, Vickers hardness, light transmittance (all, n = 15), cytotoxicity, and protein adsorption (both, n = 3). All data were analyzed by using non-parametric Kruskal-Wallis and Dunn\'s tests (α=0.05).
RESULTS: The HR groups had significantly higher flexural strength, modulus, fracture toughness, and hardness values than the CR (P < 0.001). HR3 had the highest surface roughness and light transmittance among the groups (P ≤ 0.006). None of tested resins showed cytotoxicity. Both HR2 and HR3 showed significantly lower protein adsorption than the CR, with a difference of approximately 60% (P ≤ 0.026).
CONCLUSIONS: Both HR2 and HR3 exhibited superior mechanical properties (flexural strength, flexural modulus, fracture toughness, and Vickers hardness), light transmittance, and protein-repellent activity than the CR, with no impact on cytotoxicity.
CONCLUSIONS: The MPC/silicate-based composite-filled resins may be a suitable alternative for definitive restorations, given their higher mechanical properties and promising biological properties to prevent microbial adhesion and subsequent biofilm formation, as well as their non-cytotoxic properties.