在过去的两年里,寨卡病毒已经从默默无闻地出现在世界舞台上——穿越和超越临床专业,基础科学学科,和公共卫生工作。寨卡病毒的传播对生殖内分泌学和不育的特殊性具有严重影响。我们的病人,实践,世界各地的实验室,特别是在美国,都受到了这种致畸的影响,性传播,主要是无症状病毒。虽然世界卫生组织的“国际关注的公共紧急情况”名称已经失效,因为主要流行病已经消退,对风险的理解已经部分澄清,对孕妇的急性和长期威胁尚未结束。在美国广泛传播的风险并不微不足道,除了小头畸形之外的更微妙和更长远的后果还不完全清楚,大的风险地理区域仍然包含幼稚的人口,寨卡病毒是否会继续成为流行地区的间歇性风险尚不确定。保持对寨卡病毒的最新研究是不孕症专家的重要目标。这里,我们详细回顾了最相关的最新发展,讨论适用的指导方针,并提出有助于降低寨卡病毒风险和负担的策略。
In the past 2 years,
Zika virus has emerged from obscurity onto the world stage-traversing and transcending clinical specialties, basic science disciplines, and public health efforts. The spread of
Zika virus has serious implications for the specialty of reproductive endocrinology and infertility. Our patients, practices, and labs-worldwide and specifically in the USA-have been impacted by this teratogenic, sexually transmitted, largely asymptomatic virus. While the World Health Organization\'s Public Emergency of International Concern designation has lapsed as major epidemics have subsided and understanding of risks is in part clarified, the acute and long-term threat to pregnant patients is not over. The risk of wider spread in the USA is not insignificant, the subtler and long-ranging consequences beyond microcephaly are not fully known, large geographic areas of risk still contain naïve populations, and whether Zika will continue to be an intermittent risk in endemic areas is uncertain. Staying up to date with the burgeoning research on
Zika virus is an important objective for the infertility specialist. Here, we review in detail the most relevant recent developments, discuss applicable
guidelines, and propose strategies for contributing to a reduction in the risk and burden of
Zika virus.