暂无摘要。

Although surgical resection and liver transplantation are the only treatment modalities that enable prolonged survival in patients with hepatocellular carcinoma (HCC), the majority of HCC patients presents with advanced disease and do not undergo resective or ablative therapy. Transarterial chemoembolization (TACE) is indicated in intermediate/advanced stage unresectable HCC even in the setting of portal vein involvement (excluding main portal vein). Sorafenib has been shown to improve survival of patients with advanced HCC in two controlled randomized trials. Yttrium 90 is a safe microembolization treatment that can be used as an alternative to TACE in patients with advanced liver only disease or in case of portal vein thrombosis. External beam radiation can be helpful to provide local control in selected unresectable HCC. These different treatment modalities may be combined in the treatment strategy of HCC and also used as a bridge to resection or liver transplantation. Patients should undergo formal multidisciplinary evaluation prior to initiating any such treatment in order to individualize the best available options.

High-strength, all-ceramic systems for full-coverage restorations use all-ceramic core materials for the fabrication and processing of infrastructures (eg, crown copings, fixed partial denture frameworks) that are then veneered with porcelain. Not all of these all-ceramic core materials are alike, and as such, they present with different properties that may affect their indications and limitations, the laboratory procedures used for their processing, and their clinical handling. This article reviews their clinically relevant properties and discusses the effect of these characteristics on their indications and recommended clinical procedures.
OBJECTIVE: This article provides an overview of the clinically relevant properties of high-strength, all-ceramic systems used for aesthetic restorative dentistry. Upon reading this article, the reader should: Be able to differentiate among the principal all-ceramic material systems. Understand the clinical indications for contemporary, high-strength ceramics.