节肢动物传播的病毒(虫媒病毒)继续给生活在流行地区的人们带来巨大的健康和经济负担。在这些病毒中,一些最重要的(例如,登革热,Zika,基孔肯雅,和黄热病病毒),主要由伊蚊传播。多年来,病毒感染控制有针对性的载体种群减少和抑制虫媒病毒的复制和传播。这种控制包括分类为化学的矢量控制方法,环境,生物方法。这些控制方法中的一些可以主要是实验性的(现场和实验室调查)或广泛实践。感知,病媒控制的生物学方法之一,特别是,基于Wolbachia的控制,显示了根除伊蚊传播的虫媒病毒的有希望的控制策略。这可以通过Wolbachia的人工引入,一种自然存在的细菌,阻碍蚊子中的病毒生长到异源埃及伊蚊载体(不是Wolbachia的天然宿主的载体)中,从而限制虫媒病毒传播或通过白纹伊蚊传播,自然会感染沃尔巴克氏菌。这些策略可能会被蚊子在不利的天气条件下失去Wolbachia感染的趋势所破坏(例如,高温)和共同循环的Wolbachia菌株之间的抑制性竞争动力学。这篇综述的主要目的是批判性地评估已发表的关于媒介控制策略的文章,并特别强调使用基于Wolbachia的控制来抑制媒介种群增长或破坏病毒传播。我们检索了通过节肢动物载体传播虫媒病毒的控制策略的研究,并讨论了使用Wolbachia控制策略根除虫媒病毒疾病,以确定文献空白,这将有助于开发模型来估计这些控制策略的影响,实质上,使用不同的Wolbachia菌株和功能。
Arthropod-borne viruses (Arboviruses) continue to generate significant health and economic burdens for people living in endemic regions. Of these viruses, some of the most important (e.g., dengue, Zika, chikungunya, and yellow fever virus), are transmitted mainly by Aedes mosquitoes. Over the years, viral infection control has targeted vector population reduction and inhibition of arboviral replication and transmission. This control includes the vector control methods which are classified into chemical, environmental, and biological methods. Some of these control methods may be largely experimental (both field and laboratory investigations) or widely practised. Perceptively, one of the biological methods of vector control, in particular,
Wolbachia-based control, shows a promising control strategy for eradicating Aedes-borne arboviruses. This can either be through the artificial introduction of
Wolbachia, a naturally present bacterium that impedes viral growth in mosquitoes into heterologous Aedes aegypti mosquito vectors (vectors that are not natural hosts of Wolbachia) thereby limiting arboviral transmission or via Aedes albopictus mosquitoes, which naturally harbour Wolbachia infection. These strategies are potentially undermined by the tendency of mosquitoes to lose
Wolbachia infection in unfavourable weather conditions (e.g., high temperature) and the inhibitory competitive dynamics among co-circulating Wolbachia strains. The main objective of this
review was to critically appraise published articles on vector control strategies and specifically highlight the use of
Wolbachia-based control to suppress vector population growth or disrupt viral transmission. We retrieved studies on the control strategies for arboviral transmissions via arthropod vectors and discussed the use of Wolbachia control strategies for eradicating arboviral diseases to identify literature gaps that will be instrumental in developing models to estimate the impact of these control strategies and, in essence, the use of different Wolbachia strains and features.