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Abstract：
The flavivirus West Nile virus (WNV) naturally circulates between mosquitoes and birds, potentially affecting humans and horses. Different species of mosquitoes play a role as vectors of WNV, with those of the Culex pipiens complex being particularly crucial for its circulation. Different biotic and abiotic factors determine the capacity of mosquitoes for pathogen transmission, with the mosquito gut microbiota being recognized as an important one. Here, we review the published studies on the interactions between the microbiota of the Culex pipiens complex and WNV infections in mosquitoes. Most articles published so far studied the interactions between bacteria of the genus Wolbachia and WNV infections, obtaining variable results regarding the directionality of this relationship. In contrast, only a few studies investigate the role of the whole microbiome or other bacterial taxa in WNV infections. These studies suggest that bacteria of the genera Serratia and Enterobacter may enhance WNV development. Thus, due to the relevance of WNV in human and animal health and the important role of mosquitoes of the Cx. pipiens complex in its transmission, more research is needed to unravel the role of mosquito microbiota and those factors affecting this microbiota on pathogen epidemiology. In this respect, we finally propose future lines of research lines on this topic.
摘要：
黄病毒西尼罗河病毒（WNV）自然在蚊子和鸟类之间传播，可能影响人类和马。不同种类的蚊子作为WNV的媒介发挥作用，淡色库蚊对其循环特别重要。不同的生物和非生物因素决定了蚊子传播病原体的能力，蚊子肠道微生物群被认为是一个重要的微生物群。这里,我们回顾了已发表的有关淡色库蚊复合体微生物群与蚊子WNV感染之间相互作用的研究。迄今为止发表的大多数文章研究了Wolbachia属细菌与WNV感染之间的相互作用，获得关于这种关系的方向性的可变结果。相比之下,只有少数研究调查了整个微生物组或其他细菌类群在WNV感染中的作用。这些研究表明，沙雷氏菌和肠杆菌属的细菌可能会增强WNV的发育。因此，由于WNV在人类和动物健康中的相关性以及Cx的蚊子的重要作用。pipiens复杂的传输，需要更多的研究来揭示蚊子微生物群的作用以及影响这种微生物群的因素对病原体流行病学的影响。在这方面,最后，我们提出了关于这一主题的未来研究路线。
