三阴性乳腺癌是最具侵略性的形式,占所有乳腺癌的15%-25%。三阴性乳腺癌中缺乏受体,这使得他们对目前的荷尔蒙疗法没有反应。TNBC患者可以选择细胞毒性化疗。Wnt通路与癌症有关,当被激活时,它们会导致乳腺增生和肿瘤。肿瘤抑制microRNAs可以阻断肿瘤细胞的增殖,入侵,和移民,导致癌细胞死亡,并且还已知下调WNT信号传导。与它们的单次释放相比,已经发现具有微RNA的纳米颗粒更有效。在这次审查中,我们试图了解Wnt信号如何在TNBC中起关键作用,EMT,转移,抗抗药性,以及microRNA对Wnt的调控。纳米载体在递送微RNA中的作用。临床生物标志物,包括目前最先进的,涉及Wnt的新途径。
Triple-Negative Breast Cancer is the most aggressive form and accounts the 15%-25% of all breast cancer. Receptors are absent in triple-negative breast cancer, which makes them unresponsive to the current hormonal therapies. The patients with TNBC are left with the option of cytotoxic chemotherapy. The Wnt pathways are connected to cancer, and when activated, they result in mammary hyperplasia and tumors. The tumor suppressor microRNAs can block tumor cell proliferation, invasion, and migration, lead to cancer cell death, and are also known to down-regulate the WNT signaling. Nanoparticles with microRNA have been seen to be more effective when compared with their single release. In this
review, we have tried to understand how Wnt signaling plays a crucial role in TNBC, EMT, metastasis, anti-drug resistance, and regulation of Wnt by microRNA. The role of nano-carriers in delivering micro-RNA. The clinical biomarkers, including the present state-of-the-art, involve novel pathways of Wnt.