Abstract：
Tsukushi (TSK), a leucine-rich peptidoglycan in the extracellular compartment, mediates multiple signaling pathways that are critical for development and metabolism. TSK regulates signaling pathways that eventually control cellular communication, proliferation, and cell fate determination. Research on TSK has become more sophisticated in recent years, illustrating its involvement in the physiology and pathophysiology of neural, genetic, and metabolic diseases. In a recent study, we showed that TSK therapy reversed the pathophysiological abnormalities of the hydrocephalic (a neurological disorder) brain in mice. This review summarizes the roles of TSK in key signaling processes in the mammalian development, disorders, and evaluating its possible therapeutic and diagnostic potential.
摘要：
Tsukushi(TSK),细胞外区室中富含亮氨酸的肽聚糖，介导对发育和代谢至关重要的多种信号通路。TSK调节最终控制细胞通讯的信号通路，扩散,和细胞命运决定。近年来，对TSK的研究变得越来越复杂，说明它参与神经的生理学和病理生理学，遗传,和代谢性疾病。在最近的一项研究中,我们发现TSK治疗逆转了小鼠脑积水（一种神经系统疾病）脑的病理生理异常。本文综述了TSK在哺乳动物发育中的关键信号传导过程中的作用。障碍,并评估其可能的治疗和诊断潜力。
