与麻醉对环境的负面影响有关的担忧正在增加,近年来,更多使用基于丙泊酚的全静脉麻醉是出于环境动机的趋势。因此,异丙酚废物和处置的环境负担,特别是废水,得到了关注。目前报道废水中丙泊酚水平的文献很少,这对环境的威胁尚不清楚。我们检讨进行环境风险评估的规管要求,重点是分析药物或药物代谢物是否对水生物种造成伤害的过程。此外,我们根据现有数据介绍了异丙酚的水生毒性,并讨论了这对未来实践的影响。
Concerns relating to the negative environmental impacts of anaesthesia are increasing, and in recent years, there has been an environmentally motivated trend towards greater use of propofol-based total intravenous anaesthesia. Consequently, the environmental burden of propofol waste and disposal, particularly into
wastewater, has gained attention. Current literature reporting levels of propofol in
wastewater are scarce and the threat this presents to the environment is unclear. We review the regulatory requirements for conducting an environmental risk assessment, with a focus on the process for analysing whether drugs or drug metabolites cause harm to aquatic species. Furthermore, we present a profile for the aquatic toxicity of propofol based on available data and discuss the implications of this for future practice.